JPS5649357A - Quinoline derivative - Google Patents

Quinoline derivative

Info

Publication number
JPS5649357A
JPS5649357A JP12556379A JP12556379A JPS5649357A JP S5649357 A JPS5649357 A JP S5649357A JP 12556379 A JP12556379 A JP 12556379A JP 12556379 A JP12556379 A JP 12556379A JP S5649357 A JPS5649357 A JP S5649357A
Authority
JP
Japan
Prior art keywords
formula
compounds
reaction
quinoline derivative
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12556379A
Other languages
Japanese (ja)
Other versions
JPS628114B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Oshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP12556379A priority Critical patent/JPS5649357A/en
Publication of JPS5649357A publication Critical patent/JPS5649357A/en
Publication of JPS628114B2 publication Critical patent/JPS628114B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (R is H, lower alkyl; X is halogen; Y is lower alkylene) and their salts.
EXAMPLE: 2-chloro-7-[3-(4-phenyl-1-piperazinyl)propoxy]quinoline.
USE: Antihistamic, central nervous system depressant and synthetic intermediate of thiocarbosytrile derivative, which have similar medicinal activities.
PREPARATION: The reaction between compounds of formula 2 and 3 is conducted by the use of a basic compound as a hydrohalide acceptor at 50W150°C for severalW 15hr, the reaction between compounds of formula 4 and 5 is effected at 60W120°C for several to 24hr or the reaction between compounds of formula 6 and 7 is carried out at 80W110°C for 3W8hr to produce the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP12556379A 1979-09-28 1979-09-28 Quinoline derivative Granted JPS5649357A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12556379A JPS5649357A (en) 1979-09-28 1979-09-28 Quinoline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12556379A JPS5649357A (en) 1979-09-28 1979-09-28 Quinoline derivative

Publications (2)

Publication Number Publication Date
JPS5649357A true JPS5649357A (en) 1981-05-02
JPS628114B2 JPS628114B2 (en) 1987-02-20

Family

ID=14913282

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12556379A Granted JPS5649357A (en) 1979-09-28 1979-09-28 Quinoline derivative

Country Status (1)

Country Link
JP (1) JPS5649357A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011063594A (en) * 2002-11-12 2011-03-31 Abbott Lab Bicyclic-substituted amine as histamine-3 receptor ligand

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011063594A (en) * 2002-11-12 2011-03-31 Abbott Lab Bicyclic-substituted amine as histamine-3 receptor ligand

Also Published As

Publication number Publication date
JPS628114B2 (en) 1987-02-20

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