JPS5648888A - Preparation of optical active compound - Google Patents
Preparation of optical active compoundInfo
- Publication number
- JPS5648888A JPS5648888A JP12415479A JP12415479A JPS5648888A JP S5648888 A JPS5648888 A JP S5648888A JP 12415479 A JP12415479 A JP 12415479A JP 12415479 A JP12415479 A JP 12415479A JP S5648888 A JPS5648888 A JP S5648888A
- Authority
- JP
- Japan
- Prior art keywords
- ester
- active compound
- acyloxy
- optical active
- asymmetric hydrolysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare an optical active compound industrially advantageously, by subjecting a specific ester to asymmetric hydrolysis with a lipase capable of hydrolyzing the ester asymmetrically.
CONSTITUTION: A lipase, e.g., steapsin, or a bacterium, e.g., one belonging to the genus Geotrichum, capable of hydrolyzing an ester asymmetrically, and the ester shown by the formula (X is acyloxy; Y is hologen, acyloxy, or oxygen which forms oxirane ring in combination with Z; Z is holomethyl or acyloxymethyl when Y is halogen, Z is halomethyl or aryl when Y is acyloxy, and Z is methylene which forms oxirane ring in combination with Y when Y is oxygen) are added to a buffer solution sufficiently enough to neutralize an acid to be formed in asymmetric hydrolysis, and the ester is subjected to asymmetric hydrolysis. The ester and alcohol are extracted with an organic solvent, and the ester is separated from alcohol by washing with water, chromatography, etc. to give an optical active compound.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12415479A JPS5648888A (en) | 1979-09-28 | 1979-09-28 | Preparation of optical active compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12415479A JPS5648888A (en) | 1979-09-28 | 1979-09-28 | Preparation of optical active compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5648888A true JPS5648888A (en) | 1981-05-02 |
JPS6155954B2 JPS6155954B2 (en) | 1986-11-29 |
Family
ID=14878270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12415479A Granted JPS5648888A (en) | 1979-09-28 | 1979-09-28 | Preparation of optical active compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5648888A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0080827A2 (en) * | 1981-11-28 | 1983-06-08 | Sumitomo Chemical Company, Limited | Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol |
JPS58169337A (en) * | 1982-03-31 | 1983-10-05 | Hitachi Ltd | Device for recording and detecting mark in optical disc |
EP0148272A1 (en) * | 1983-05-09 | 1985-07-17 | Sumitomo Chemical Company, Limited | Process for producing optically active benzyl alcohol compounds |
JPS61192074A (en) * | 1985-02-20 | 1986-08-26 | Canon Inc | Information record carrier |
JPH01257484A (en) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | Production of optically active secondary alcohol |
US4985365A (en) * | 1981-11-28 | 1991-01-15 | Sumitomo Chemical Company, Ltd. | Process for producing optically active benzyl alcohol compound |
JPH05189882A (en) * | 1992-06-29 | 1993-07-30 | Hitachi Ltd | Recorder/reproducer |
JPH06295472A (en) * | 1993-12-15 | 1994-10-21 | Hitachi Ltd | Optical disk medium |
JPH0855430A (en) * | 1995-08-09 | 1996-02-27 | Hitachi Ltd | Information recorder and optical information recording medium |
-
1979
- 1979-09-28 JP JP12415479A patent/JPS5648888A/en active Granted
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0080827A2 (en) * | 1981-11-28 | 1983-06-08 | Sumitomo Chemical Company, Limited | Method for biotechnologically preparing (S)-(-)-alpha-cyano-3-phenoxybenzyl alcohol |
US4985365A (en) * | 1981-11-28 | 1991-01-15 | Sumitomo Chemical Company, Ltd. | Process for producing optically active benzyl alcohol compound |
JPS58169337A (en) * | 1982-03-31 | 1983-10-05 | Hitachi Ltd | Device for recording and detecting mark in optical disc |
EP0148272A1 (en) * | 1983-05-09 | 1985-07-17 | Sumitomo Chemical Company, Limited | Process for producing optically active benzyl alcohol compounds |
JPS61192074A (en) * | 1985-02-20 | 1986-08-26 | Canon Inc | Information record carrier |
JPH01257484A (en) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | Production of optically active secondary alcohol |
JPH05189882A (en) * | 1992-06-29 | 1993-07-30 | Hitachi Ltd | Recorder/reproducer |
JPH06295472A (en) * | 1993-12-15 | 1994-10-21 | Hitachi Ltd | Optical disk medium |
JP2765464B2 (en) * | 1993-12-15 | 1998-06-18 | 株式会社日立製作所 | Mark element arrangement method for optical disk medium |
JPH0855430A (en) * | 1995-08-09 | 1996-02-27 | Hitachi Ltd | Information recorder and optical information recording medium |
Also Published As
Publication number | Publication date |
---|---|
JPS6155954B2 (en) | 1986-11-29 |
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