JPS5640664A - Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino propan-1-oil - Google Patents
Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino propan-1-oilInfo
- Publication number
- JPS5640664A JPS5640664A JP11754379A JP11754379A JPS5640664A JP S5640664 A JPS5640664 A JP S5640664A JP 11754379 A JP11754379 A JP 11754379A JP 11754379 A JP11754379 A JP 11754379A JP S5640664 A JPS5640664 A JP S5640664A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- benzylpyridine
- catalyst
- platinum oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
PURPOSE: To obtain the titled substance readily in high yield, by reducing a pyridinium halogenoid obtained from commercially available 4-benzylpyridine and a p- hydroxy-α-halogenopropiophenone in the presence of a catalyst, e.g. platinum oxide.
CONSTITUTION: 4-Benzylpyridine is reacted with a compound of formula I (X is halogen) in a nonpolar solvent, e.g. benzene, for 4W10hr to give a compound of formula II, which is then reduced in the presence of a catalyst, e.g. platinum oxide or Raney nickel, to afford a compound of formula III. The reduction is carried out in a mixed solvent of water and an alcohol with an alcohol content of 60W0%, and the amount of the catalyst is 4W8wt% based on the compound of formula II. In the case of platinum oxide, the amount is 2W4wt%.
EFFECT: The 4-benzylpyridine is usable directly in the commerically avaiable form, and the compound of formula II can be used without protecting the OH group.
USE: A blocking agent for α-acceptors.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54117543A JPS6034951B2 (en) | 1979-09-13 | 1979-09-13 | Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54117543A JPS6034951B2 (en) | 1979-09-13 | 1979-09-13 | Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59249387A Division JPS61148161A (en) | 1984-11-26 | 1984-11-26 | 1-(2-(4-hydroxyphenylcarbonyl)ethyl)-4-benzylpyridinium salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5640664A true JPS5640664A (en) | 1981-04-16 |
JPS6034951B2 JPS6034951B2 (en) | 1985-08-12 |
Family
ID=14714395
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54117543A Expired JPS6034951B2 (en) | 1979-09-13 | 1979-09-13 | Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6034951B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005263662A (en) * | 2004-03-17 | 2005-09-29 | Kanto Chem Co Inc | Method for producing optically active alcohol having nitrogen-containing heterocyclic ring |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4867234A (en) * | 1971-12-15 | 1973-09-13 | ||
JPS504081A (en) * | 1972-12-04 | 1975-01-16 |
-
1979
- 1979-09-13 JP JP54117543A patent/JPS6034951B2/en not_active Expired
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4867234A (en) * | 1971-12-15 | 1973-09-13 | ||
JPS504081A (en) * | 1972-12-04 | 1975-01-16 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005263662A (en) * | 2004-03-17 | 2005-09-29 | Kanto Chem Co Inc | Method for producing optically active alcohol having nitrogen-containing heterocyclic ring |
Also Published As
Publication number | Publication date |
---|---|
JPS6034951B2 (en) | 1985-08-12 |
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