JPS5640664A - Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino propan-1-oil - Google Patents

Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino propan-1-oil

Info

Publication number
JPS5640664A
JPS5640664A JP11754379A JP11754379A JPS5640664A JP S5640664 A JPS5640664 A JP S5640664A JP 11754379 A JP11754379 A JP 11754379A JP 11754379 A JP11754379 A JP 11754379A JP S5640664 A JPS5640664 A JP S5640664A
Authority
JP
Japan
Prior art keywords
compound
formula
benzylpyridine
catalyst
platinum oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11754379A
Other languages
Japanese (ja)
Other versions
JPS6034951B2 (en
Inventor
Hajime Nakayama
Masatoshi Ishikura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOYO PHARMA KK
TOYO PHARMA- KK
Original Assignee
TOYO PHARMA KK
TOYO PHARMA- KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOYO PHARMA KK, TOYO PHARMA- KK filed Critical TOYO PHARMA KK
Priority to JP54117543A priority Critical patent/JPS6034951B2/en
Publication of JPS5640664A publication Critical patent/JPS5640664A/en
Publication of JPS6034951B2 publication Critical patent/JPS6034951B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

PURPOSE: To obtain the titled substance readily in high yield, by reducing a pyridinium halogenoid obtained from commercially available 4-benzylpyridine and a p- hydroxy-α-halogenopropiophenone in the presence of a catalyst, e.g. platinum oxide.
CONSTITUTION: 4-Benzylpyridine is reacted with a compound of formula I (X is halogen) in a nonpolar solvent, e.g. benzene, for 4W10hr to give a compound of formula II, which is then reduced in the presence of a catalyst, e.g. platinum oxide or Raney nickel, to afford a compound of formula III. The reduction is carried out in a mixed solvent of water and an alcohol with an alcohol content of 60W0%, and the amount of the catalyst is 4W8wt% based on the compound of formula II. In the case of platinum oxide, the amount is 2W4wt%.
EFFECT: The 4-benzylpyridine is usable directly in the commerically avaiable form, and the compound of formula II can be used without protecting the OH group.
USE: A blocking agent for α-acceptors.
COPYRIGHT: (C)1981,JPO&Japio
JP54117543A 1979-09-13 1979-09-13 Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol Expired JPS6034951B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP54117543A JPS6034951B2 (en) 1979-09-13 1979-09-13 Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54117543A JPS6034951B2 (en) 1979-09-13 1979-09-13 Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP59249387A Division JPS61148161A (en) 1984-11-26 1984-11-26 1-(2-(4-hydroxyphenylcarbonyl)ethyl)-4-benzylpyridinium salt

Publications (2)

Publication Number Publication Date
JPS5640664A true JPS5640664A (en) 1981-04-16
JPS6034951B2 JPS6034951B2 (en) 1985-08-12

Family

ID=14714395

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54117543A Expired JPS6034951B2 (en) 1979-09-13 1979-09-13 Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol

Country Status (1)

Country Link
JP (1) JPS6034951B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005263662A (en) * 2004-03-17 2005-09-29 Kanto Chem Co Inc Method for producing optically active alcohol having nitrogen-containing heterocyclic ring

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4867234A (en) * 1971-12-15 1973-09-13
JPS504081A (en) * 1972-12-04 1975-01-16

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4867234A (en) * 1971-12-15 1973-09-13
JPS504081A (en) * 1972-12-04 1975-01-16

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005263662A (en) * 2004-03-17 2005-09-29 Kanto Chem Co Inc Method for producing optically active alcohol having nitrogen-containing heterocyclic ring

Also Published As

Publication number Publication date
JPS6034951B2 (en) 1985-08-12

Similar Documents

Publication Publication Date Title
JPS5640664A (en) Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino propan-1-oil
JPS55108850A (en) Preparation of indole or indole derivative
JPS5592348A (en) Preparation of 1,17-diamino-9-azaheptadecane
JPS545903A (en) Preparation of 4-aminomethyl-1,8-diaminooctane
JPS5615252A (en) Preparation of anthrimide or anthraouinonylaminobenzanthrone
JPS5542068A (en) Detecting agent
JPS5711967A (en) Preparation of 2,2,4-trimethyl-1,2-dihydroquinoline
JPS5293762A (en) Preparation of cyclic ethers
JPS55108883A (en) Ethyl-(gamma-acetamino-gamma-ethoxycarbonyl-gamma-cyanopropyl- methyl) phosphinate and its preparation
JPS523587A (en) Water and oil repelling agent
JPS5315350A (en) Preparation of 2-hydroxy-1,4-naphthoquinone
JPS5528755A (en) Emulsifier composition
JPS5495533A (en) Preparation of derivative of anthranylaldehyde
JPS54125620A (en) Preparation of diazomethane derivative
JPS53147010A (en) Preparation of propylene oxide
JPS5318521A (en) Preparation of 3,5-dichloronitrogenzene
JPS56167650A (en) Preparation of diphenylamine
JPS5398917A (en) Preparation of ethyleneglycol monoether
JPS52148037A (en) Preparation of per-#-toluylic acid
JPS5312830A (en) Preparation of dinitrodiphenyl ether
JPS5522622A (en) Preparation of epoxyterpene
JPS5517361A (en) 7-methylene-cis-decalin-2-one
JPS5331651A (en) Preparation of 2-amino-3-chloro-1, 4-naphthoquinone
JPS5429327A (en) Bispiropirazine compound, its preparation, and its use as pigment
JPS5673037A (en) Preparation of polyprenyl alcohol