JPS5632493A - Antitumor active substance, its preparation and pharmaceutical - Google Patents
Antitumor active substance, its preparation and pharmaceuticalInfo
- Publication number
- JPS5632493A JPS5632493A JP10859279A JP10859279A JPS5632493A JP S5632493 A JPS5632493 A JP S5632493A JP 10859279 A JP10859279 A JP 10859279A JP 10859279 A JP10859279 A JP 10859279A JP S5632493 A JPS5632493 A JP S5632493A
- Authority
- JP
- Japan
- Prior art keywords
- active substance
- precipitate
- antitumor
- coagulant
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
NEW MATERIAL:An antitumor active substance obtained as a precipitate by adding a coagulant to a cell-free extract prepared from a crushed bacterium body of a microorganism belonging to the genus Nocardia.
USE: An antitumor agent with slight toxicity and side effects, manufacturable by a simple method and in high yield, usable as an injection in the form of an emulsion in water and/or oil and exhibiting a powerful antitumor activity against both solid cancer and ascitic cancer.
PROCESS: A microbial body of Nocardia rubra ATCC 14898 strain is crushed and filtered to give a cell-free extract. A coagulatnt. e.g. aluminum sulfate or streptomycin, is added to the extract to precipitate and separate and active substance. The resultant precipitate is then preferably dialyzed to remove the coagulant and freeze- dried to give the aimed active substance. All the operations are preferably carried out at 0W10°C.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10859279A JPS5632493A (en) | 1979-08-28 | 1979-08-28 | Antitumor active substance, its preparation and pharmaceutical |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10859279A JPS5632493A (en) | 1979-08-28 | 1979-08-28 | Antitumor active substance, its preparation and pharmaceutical |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5632493A true JPS5632493A (en) | 1981-04-01 |
Family
ID=14488709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10859279A Pending JPS5632493A (en) | 1979-08-28 | 1979-08-28 | Antitumor active substance, its preparation and pharmaceutical |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5632493A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62122929U (en) * | 1986-01-27 | 1987-08-04 | ||
CN100341574C (en) * | 2005-07-08 | 2007-10-10 | 中国药科大学 | Novel use of cell wall skeleton of red nocar-ray-fungus for treating liver diseases |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5266691A (en) * | 1975-11-26 | 1977-06-02 | Ajinomoto Co Inc | Preparation of carcinostatic agent |
-
1979
- 1979-08-28 JP JP10859279A patent/JPS5632493A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5266691A (en) * | 1975-11-26 | 1977-06-02 | Ajinomoto Co Inc | Preparation of carcinostatic agent |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62122929U (en) * | 1986-01-27 | 1987-08-04 | ||
JPH0547320Y2 (en) * | 1986-01-27 | 1993-12-13 | ||
CN100341574C (en) * | 2005-07-08 | 2007-10-10 | 中国药科大学 | Novel use of cell wall skeleton of red nocar-ray-fungus for treating liver diseases |
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