JPS5632493A - Antitumor active substance, its preparation and pharmaceutical - Google Patents

Antitumor active substance, its preparation and pharmaceutical

Info

Publication number
JPS5632493A
JPS5632493A JP10859279A JP10859279A JPS5632493A JP S5632493 A JPS5632493 A JP S5632493A JP 10859279 A JP10859279 A JP 10859279A JP 10859279 A JP10859279 A JP 10859279A JP S5632493 A JPS5632493 A JP S5632493A
Authority
JP
Japan
Prior art keywords
active substance
precipitate
antitumor
coagulant
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10859279A
Other languages
Japanese (ja)
Inventor
Tadashi Sudo
Yoshio Furuya
Koichi Konda
Hiroshi Yamamoto
Masanobu Arita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP10859279A priority Critical patent/JPS5632493A/en
Publication of JPS5632493A publication Critical patent/JPS5632493A/en
Pending legal-status Critical Current

Links

Landscapes

  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

NEW MATERIAL:An antitumor active substance obtained as a precipitate by adding a coagulant to a cell-free extract prepared from a crushed bacterium body of a microorganism belonging to the genus Nocardia.
USE: An antitumor agent with slight toxicity and side effects, manufacturable by a simple method and in high yield, usable as an injection in the form of an emulsion in water and/or oil and exhibiting a powerful antitumor activity against both solid cancer and ascitic cancer.
PROCESS: A microbial body of Nocardia rubra ATCC 14898 strain is crushed and filtered to give a cell-free extract. A coagulatnt. e.g. aluminum sulfate or streptomycin, is added to the extract to precipitate and separate and active substance. The resultant precipitate is then preferably dialyzed to remove the coagulant and freeze- dried to give the aimed active substance. All the operations are preferably carried out at 0W10°C.
COPYRIGHT: (C)1981,JPO&Japio
JP10859279A 1979-08-28 1979-08-28 Antitumor active substance, its preparation and pharmaceutical Pending JPS5632493A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10859279A JPS5632493A (en) 1979-08-28 1979-08-28 Antitumor active substance, its preparation and pharmaceutical

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10859279A JPS5632493A (en) 1979-08-28 1979-08-28 Antitumor active substance, its preparation and pharmaceutical

Publications (1)

Publication Number Publication Date
JPS5632493A true JPS5632493A (en) 1981-04-01

Family

ID=14488709

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10859279A Pending JPS5632493A (en) 1979-08-28 1979-08-28 Antitumor active substance, its preparation and pharmaceutical

Country Status (1)

Country Link
JP (1) JPS5632493A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62122929U (en) * 1986-01-27 1987-08-04
CN100341574C (en) * 2005-07-08 2007-10-10 中国药科大学 Novel use of cell wall skeleton of red nocar-ray-fungus for treating liver diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5266691A (en) * 1975-11-26 1977-06-02 Ajinomoto Co Inc Preparation of carcinostatic agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5266691A (en) * 1975-11-26 1977-06-02 Ajinomoto Co Inc Preparation of carcinostatic agent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62122929U (en) * 1986-01-27 1987-08-04
JPH0547320Y2 (en) * 1986-01-27 1993-12-13
CN100341574C (en) * 2005-07-08 2007-10-10 中国药科大学 Novel use of cell wall skeleton of red nocar-ray-fungus for treating liver diseases

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