JPS56138115A - Suppository containing acidic amino acid or derivative thereof - Google Patents

Info

Publication number

JPS56138115A

JPS56138115A JP4036980A JP4036980A JPS56138115A JP S56138115 A JPS56138115 A JP S56138115A JP 4036980 A JP4036980 A JP 4036980A JP 4036980 A JP4036980 A JP 4036980A JP S56138115 A JPS56138115 A JP S56138115A

Authority

JP

Japan

Prior art keywords

derivative

amino acid

acidic amino

suppository

medicament

Prior art date

1980-03-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000002378 acidificating effect Effects 0.000 title abstract 4
• 150000001413 amino acids Chemical class 0.000 title abstract 4
• 239000000829 suppository Substances 0.000 title abstract 4
• 150000001412 amines Chemical class 0.000 title 1
• 229940024606 amino acid Drugs 0.000 abstract 3
• 239000003814 drug Substances 0.000 abstract 3
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
• 102000055006 Calcitonin Human genes 0.000 abstract 1
• 108060001064 Calcitonin Proteins 0.000 abstract 1
• 102000004190 Enzymes Human genes 0.000 abstract 1
• 108090000790 Enzymes Proteins 0.000 abstract 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
• 102000004877 Insulin Human genes 0.000 abstract 1
• 108090001061 Insulin Proteins 0.000 abstract 1
• 238000010521 absorption reaction Methods 0.000 abstract 1
• 230000003115 biocidal effect Effects 0.000 abstract 1
• BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
• 229960004015 calcitonin Drugs 0.000 abstract 1
• 230000003327 cancerostatic effect Effects 0.000 abstract 1
• 239000003795 chemical substances by application Substances 0.000 abstract 1
• PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 abstract 1
• 229940088598 enzyme Drugs 0.000 abstract 1
• 150000004676 glycans Chemical class 0.000 abstract 1
• -1 heparin Chemical compound 0.000 abstract 1
• 229920000669 heparin Polymers 0.000 abstract 1
• 229960002897 heparin Drugs 0.000 abstract 1
• 238000002347 injection Methods 0.000 abstract 1
• 239000007924 injection Substances 0.000 abstract 1
• 229940125396 insulin Drugs 0.000 abstract 1
• 239000000203 mixture Substances 0.000 abstract 1
• 235000013923 monosodium glutamate Nutrition 0.000 abstract 1
• 239000000813 peptide hormone Substances 0.000 abstract 1
• 229920001282 polysaccharide Polymers 0.000 abstract 1
• 239000005017 polysaccharide Substances 0.000 abstract 1
• 229910052708 sodium Inorganic materials 0.000 abstract 1
• 239000011734 sodium Substances 0.000 abstract 1
• 229940073490 sodium glutamate Drugs 0.000 abstract 1

Cited By (3)