JPS56127338A - Basic amino acid salt of diclofenac and suppository containing the same - Google Patents
Basic amino acid salt of diclofenac and suppository containing the sameInfo
- Publication number
- JPS56127338A JPS56127338A JP3108080A JP3108080A JPS56127338A JP S56127338 A JPS56127338 A JP S56127338A JP 3108080 A JP3108080 A JP 3108080A JP 3108080 A JP3108080 A JP 3108080A JP S56127338 A JPS56127338 A JP S56127338A
- Authority
- JP
- Japan
- Prior art keywords
- diclofenac
- salt
- amino acid
- formula
- lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title abstract 6
- 229960001259 diclofenac Drugs 0.000 title abstract 5
- -1 amino acid salt Chemical class 0.000 title abstract 2
- 239000000829 suppository Substances 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000004475 Arginine Substances 0.000 abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004472 Lysine Substances 0.000 abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 210000000664 rectum Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3108080A JPS56127338A (en) | 1980-03-10 | 1980-03-10 | Basic amino acid salt of diclofenac and suppository containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3108080A JPS56127338A (en) | 1980-03-10 | 1980-03-10 | Basic amino acid salt of diclofenac and suppository containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56127338A true JPS56127338A (en) | 1981-10-06 |
| JPH0223527B2 JPH0223527B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-05-24 |
Family
ID=12321441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3108080A Granted JPS56127338A (en) | 1980-03-10 | 1980-03-10 | Basic amino acid salt of diclofenac and suppository containing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56127338A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56138115A (en) * | 1980-03-31 | 1981-10-28 | Teijin Ltd | Suppository containing acidic amino acid or derivative thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5089517A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-12-18 | 1975-07-18 | ||
| JPS50126818A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-03-07 | 1975-10-06 | ||
| JPS54109942A (en) * | 1978-02-13 | 1979-08-29 | Mitsui Toatsu Chem Inc | Preparation of phenylacetic acid derivative |
-
1980
- 1980-03-10 JP JP3108080A patent/JPS56127338A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5089517A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1973-12-18 | 1975-07-18 | ||
| JPS50126818A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1974-03-07 | 1975-10-06 | ||
| JPS54109942A (en) * | 1978-02-13 | 1979-08-29 | Mitsui Toatsu Chem Inc | Preparation of phenylacetic acid derivative |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56138115A (en) * | 1980-03-31 | 1981-10-28 | Teijin Ltd | Suppository containing acidic amino acid or derivative thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0223527B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-05-24 |
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