JPS56122374A - Hypocholesterolemic hydrogenation product and its manufacture - Google Patents

Hypocholesterolemic hydrogenation product and its manufacture

Info

Publication number
JPS56122374A
JPS56122374A JP1447881A JP1447881A JPS56122374A JP S56122374 A JPS56122374 A JP S56122374A JP 1447881 A JP1447881 A JP 1447881A JP 1447881 A JP1447881 A JP 1447881A JP S56122374 A JPS56122374 A JP S56122374A
Authority
JP
Japan
Prior art keywords
hypocholesterolemic
manufacture
hydrogenation
hydrogenation product
results
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1447881A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0136471B2 (en:Method
Inventor
Ee Pachietsuto Aasaa
Kuo Kuannhoa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS56122374A publication Critical patent/JPS56122374A/ja
Publication of JPH0136471B2 publication Critical patent/JPH0136471B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP1447881A 1980-02-04 1981-02-04 Hypocholesterolemic hydrogenation product and its manufacture Granted JPS56122374A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11805080A 1980-02-04 1980-02-04

Publications (2)

Publication Number Publication Date
JPS56122374A true JPS56122374A (en) 1981-09-25
JPH0136471B2 JPH0136471B2 (en:Method) 1989-07-31

Family

ID=22376236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1447881A Granted JPS56122374A (en) 1980-02-04 1981-02-04 Hypocholesterolemic hydrogenation product and its manufacture

Country Status (9)

Country Link
EP (1) EP0033537B1 (en:Method)
JP (1) JPS56122374A (en:Method)
AT (1) ATE13534T1 (en:Method)
DE (1) DE3170666D1 (en:Method)
DK (1) DK45981A (en:Method)
ES (1) ES499078A0 (en:Method)
GR (1) GR73077B (en:Method)
IE (1) IE51477B1 (en:Method)
PT (1) PT72394B (en:Method)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57185274A (en) * 1981-05-07 1982-11-15 Sankyo Co Ltd Tetrahydro-mb-530b and its derivative

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739768A (en) * 1954-09-27 1956-03-27 August C Purpura Aircraft having feathering airfoils
AU548996B2 (en) 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS57185276A (en) * 1981-05-11 1982-11-15 Sankyo Co Ltd Dihydro-dum-4 and dihydro-isodum-4 and their derivative
DE3481190D1 (de) * 1983-10-11 1990-03-08 Merck & Co Inc Verfahren zur herstellung von 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)-2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)-decahydronaphthyl-1(s))ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-on.
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
US4885314A (en) * 1987-06-29 1989-12-05 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
DE3884536T2 (de) * 1987-09-03 1994-04-28 Merck & Co Inc Hydrierverfahren zur Bildung von Di- oder Tetrahydro-HMG-CoA-Reduktase-Inhibitoren.
US5089523A (en) * 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
EP1007033B1 (en) * 1997-08-28 2008-04-23 Novartis AG Lymphocyte function antigen-1 antagonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559024A (en) * 1978-07-04 1980-01-22 Sankyo Co Ltd Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049495A (en) * 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5612114B2 (en:Method) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559024A (en) * 1978-07-04 1980-01-22 Sankyo Co Ltd Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57185274A (en) * 1981-05-07 1982-11-15 Sankyo Co Ltd Tetrahydro-mb-530b and its derivative

Also Published As

Publication number Publication date
EP0033537A2 (en) 1981-08-12
PT72394A (en) 1981-02-01
EP0033537B1 (en) 1985-05-29
DE3170666D1 (en) 1985-07-04
IE51477B1 (en) 1987-01-07
EP0033537A3 (en) 1982-02-24
ATE13534T1 (de) 1985-06-15
DK45981A (da) 1981-08-05
ES8202550A1 (es) 1982-02-01
GR73077B (en:Method) 1984-01-31
IE810168L (en) 1981-08-04
PT72394B (en) 1982-09-06
JPH0136471B2 (en:Method) 1989-07-31
ES499078A0 (es) 1982-02-01

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