ES8202550A1 - Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicos - Google Patents
Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicosInfo
- Publication number
- ES8202550A1 ES8202550A1 ES499078A ES499078A ES8202550A1 ES 8202550 A1 ES8202550 A1 ES 8202550A1 ES 499078 A ES499078 A ES 499078A ES 499078 A ES499078 A ES 499078A ES 8202550 A1 ES8202550 A1 ES 8202550A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- dihydromevinolin
- mevinolin
- preparing
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE PRODUCTOS DE HIDROGENACION HIPOCOLESTEROLEMICOS, DE FORMULA (I), Y DE SU FORMA ACIDA LIBRE, DE FORMULA (II), ASI COMO DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES, EN CUYA FORMULA (II) LAS LINEAS DE PUNTOS A O B SON DOBLES ENLACES OPCIONALES Y SI NINGUNO ES DOBLE ENLACE, EL ANILLO DE PERHIDRONAFTILO SE ENCUENTRA EN LA CONFIGURACION 4A, 8A. CONSISTE EN LA REACCION DE HIDROGENACION DE UN COMPUESTO DE FORMULA (III) SOBRE TRI(TRIFENILFOSFONIO)-CLORURO DE RODIO CUANDO B HA DE SER DOBLE ENLACE, O SOBRE PALADIO EN CARBONATO CALCICO SI A HA DE SER DOBLE ENLACE, O SOBRE OXIDO DE PLATINO CUANDO NI A NI B SON DOBLE ENLACE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11805080A | 1980-02-04 | 1980-02-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES499078A0 ES499078A0 (es) | 1982-02-01 |
ES8202550A1 true ES8202550A1 (es) | 1982-02-01 |
Family
ID=22376236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES499078A Expired ES8202550A1 (es) | 1980-02-04 | 1981-02-03 | Un procedimiento para la produccion de productos de hidroge-nacion hipocolesterolemicos |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0033537B1 (es) |
JP (1) | JPS56122374A (es) |
AT (1) | ATE13534T1 (es) |
DE (1) | DE3170666D1 (es) |
DK (1) | DK45981A (es) |
ES (1) | ES8202550A1 (es) |
GR (1) | GR73077B (es) |
IE (1) | IE51477B1 (es) |
PT (1) | PT72394B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2739768A (en) * | 1954-09-27 | 1956-03-27 | August C Purpura | Aircraft having feathering airfoils |
AU548996B2 (en) | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
JPS57185274A (en) * | 1981-05-07 | 1982-11-15 | Sankyo Co Ltd | Tetrahydro-mb-530b and its derivative |
JPS57185276A (en) * | 1981-05-11 | 1982-11-15 | Sankyo Co Ltd | Dihydro-dum-4 and dihydro-isodum-4 and their derivative |
EP0137445B1 (en) * | 1983-10-11 | 1990-01-03 | Merck & Co. Inc. | Process for c-methylation of 2-methylbutyrates |
EP0137444B1 (en) * | 1983-10-11 | 1990-01-31 | Merck & Co. Inc. | Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-Decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one |
US4885314A (en) * | 1987-06-29 | 1989-12-05 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
DE3884536T2 (de) * | 1987-09-03 | 1994-04-28 | Merck & Co Inc | Hydrierverfahren zur Bildung von Di- oder Tetrahydro-HMG-CoA-Reduktase-Inhibitoren. |
US5089523A (en) * | 1990-05-11 | 1992-02-18 | E. R. Squibb & Sons, Inc. | Fluorinated derivatives of mevinic acids |
US5250435A (en) * | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
PT1007033E (pt) * | 1997-08-28 | 2008-07-22 | Novartis Ag | Antagonistas do antigénio-1 da função de linfócitos |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049495A (en) * | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
JPS5612114B2 (es) * | 1974-06-07 | 1981-03-18 | ||
JPS6026094B2 (ja) * | 1978-07-04 | 1985-06-21 | 三共株式会社 | テトラヒドロml↓−236bおよびその誘導体並びにそれを有効成分とする高脂血症治療剤 |
JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
IL60219A (en) * | 1979-06-15 | 1985-05-31 | Merck & Co Inc | Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them |
-
1981
- 1981-01-23 PT PT72394A patent/PT72394B/pt unknown
- 1981-01-29 IE IE168/81A patent/IE51477B1/en unknown
- 1981-02-02 EP EP81100728A patent/EP0033537B1/en not_active Expired
- 1981-02-02 AT AT81100728T patent/ATE13534T1/de not_active IP Right Cessation
- 1981-02-02 GR GR64029A patent/GR73077B/el unknown
- 1981-02-02 DE DE8181100728T patent/DE3170666D1/de not_active Expired
- 1981-02-03 DK DK45981A patent/DK45981A/da not_active Application Discontinuation
- 1981-02-03 ES ES499078A patent/ES8202550A1/es not_active Expired
- 1981-02-04 JP JP1447881A patent/JPS56122374A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0136471B2 (es) | 1989-07-31 |
EP0033537A2 (en) | 1981-08-12 |
ES499078A0 (es) | 1982-02-01 |
EP0033537A3 (en) | 1982-02-24 |
DK45981A (da) | 1981-08-05 |
GR73077B (es) | 1984-01-31 |
PT72394B (en) | 1982-09-06 |
ATE13534T1 (de) | 1985-06-15 |
IE810168L (en) | 1981-08-04 |
IE51477B1 (en) | 1987-01-07 |
EP0033537B1 (en) | 1985-05-29 |
PT72394A (en) | 1981-02-01 |
JPS56122374A (en) | 1981-09-25 |
DE3170666D1 (en) | 1985-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960401 |