JPS56120694A - Preparation of neocarzinostatin ma - Google Patents
Preparation of neocarzinostatin maInfo
- Publication number
- JPS56120694A JPS56120694A JP2386580A JP2386580A JPS56120694A JP S56120694 A JPS56120694 A JP S56120694A JP 2386580 A JP2386580 A JP 2386580A JP 2386580 A JP2386580 A JP 2386580A JP S56120694 A JPS56120694 A JP S56120694A
- Authority
- JP
- Japan
- Prior art keywords
- substance
- neocarzinostatin
- ncs
- antagonistic
- unreacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare neocarzinostatin Ma useful as a carcinostatic agent, by reacting a neocarzinostatin antagonistic substance with NCS-C substance.
CONSTITUTION: A neocarzinostatin antagonistic substance is dissolved in a buffer solution of pH4W7, and reacted with NCS-C substance dissolved in a small amount of solvent such as methanol, ethanol, etc., to obtain the objective neocarzinostatin Ma. The molar ratio of the antagonistic substance to the NCS-C substance is pref. 1:1W10. The reaction is carried out at 20W60°C for 12W120hr under stirring. After the reaction, the unreacted antagonistic substance is removed by ion-exchange chromatography using CM-cellulose, etc., and the unreacted NCS-C substance is removed, e.g. by dialysis, gel-filtraction, etc.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2386580A JPS56120694A (en) | 1980-02-27 | 1980-02-27 | Preparation of neocarzinostatin ma |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2386580A JPS56120694A (en) | 1980-02-27 | 1980-02-27 | Preparation of neocarzinostatin ma |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56120694A true JPS56120694A (en) | 1981-09-22 |
Family
ID=12122326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2386580A Pending JPS56120694A (en) | 1980-02-27 | 1980-02-27 | Preparation of neocarzinostatin ma |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56120694A (en) |
-
1980
- 1980-02-27 JP JP2386580A patent/JPS56120694A/en active Pending
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