JPS56120694A - Preparation of neocarzinostatin ma - Google Patents

Preparation of neocarzinostatin ma

Info

Publication number
JPS56120694A
JPS56120694A JP2386580A JP2386580A JPS56120694A JP S56120694 A JPS56120694 A JP S56120694A JP 2386580 A JP2386580 A JP 2386580A JP 2386580 A JP2386580 A JP 2386580A JP S56120694 A JPS56120694 A JP S56120694A
Authority
JP
Japan
Prior art keywords
substance
neocarzinostatin
ncs
antagonistic
unreacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2386580A
Other languages
Japanese (ja)
Inventor
Yoshio Koide
Yasuo Koyama
Kiyoto Edo
Nakao Ishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP2386580A priority Critical patent/JPS56120694A/en
Publication of JPS56120694A publication Critical patent/JPS56120694A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To prepare neocarzinostatin Ma useful as a carcinostatic agent, by reacting a neocarzinostatin antagonistic substance with NCS-C substance.
CONSTITUTION: A neocarzinostatin antagonistic substance is dissolved in a buffer solution of pH4W7, and reacted with NCS-C substance dissolved in a small amount of solvent such as methanol, ethanol, etc., to obtain the objective neocarzinostatin Ma. The molar ratio of the antagonistic substance to the NCS-C substance is pref. 1:1W10. The reaction is carried out at 20W60°C for 12W120hr under stirring. After the reaction, the unreacted antagonistic substance is removed by ion-exchange chromatography using CM-cellulose, etc., and the unreacted NCS-C substance is removed, e.g. by dialysis, gel-filtraction, etc.
COPYRIGHT: (C)1981,JPO&Japio
JP2386580A 1980-02-27 1980-02-27 Preparation of neocarzinostatin ma Pending JPS56120694A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2386580A JPS56120694A (en) 1980-02-27 1980-02-27 Preparation of neocarzinostatin ma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2386580A JPS56120694A (en) 1980-02-27 1980-02-27 Preparation of neocarzinostatin ma

Publications (1)

Publication Number Publication Date
JPS56120694A true JPS56120694A (en) 1981-09-22

Family

ID=12122326

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2386580A Pending JPS56120694A (en) 1980-02-27 1980-02-27 Preparation of neocarzinostatin ma

Country Status (1)

Country Link
JP (1) JPS56120694A (en)

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