JPS56118084A - Optically active cephalosporin analogue - Google Patents

Optically active cephalosporin analogue

Info

Publication number
JPS56118084A
JPS56118084A JP2203580A JP2203580A JPS56118084A JP S56118084 A JPS56118084 A JP S56118084A JP 2203580 A JP2203580 A JP 2203580A JP 2203580 A JP2203580 A JP 2203580A JP S56118084 A JPS56118084 A JP S56118084A
Authority
JP
Japan
Prior art keywords
formula
compound
optically active
syn
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2203580A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Yukio Hashimoto
Takehiro Ogasa
Shigeru Kobayashi
Akira Sato
Kiyoshi Sato
Seigo Takazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2203580A priority Critical patent/JPS56118084A/en
Priority to ES495035A priority patent/ES495035A0/en
Priority to NO802713A priority patent/NO802713L/en
Priority to DK389080A priority patent/DK389080A/en
Priority to EP80105492A priority patent/EP0025602B1/en
Priority to DE8080105492T priority patent/DE3069832D1/en
Priority to CA000360255A priority patent/CA1178957A/en
Publication of JPS56118084A publication Critical patent/JPS56118084A/en
Priority to US06/788,660 priority patent/US4663450A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (R1 is H, alkyl, alkenyl, alkynyl, etc.; R2 is H, lower alkyl, or lower acyl; R3 is H or ester residue; the H atoms at 6- and 7-position are cis, and OR1 is syn), and its salt.
EXAMPLE: (4S,6R,7S)-7-[2-(2-Amino-4-thiazolyl)-2-syn-methoxyiminoacetamido]-4- hydroxy-1-azabicyclo[4,2,0]oct-2-en-8-one-2-carboxylic acid.
USE: Drug having strong antibacterial activity to Gram-negative bacteria and Gram- positive bacteria.
PROCESS: An optically active isomer of a cephalosporin analogue of formula V-1 is acylated with a reactive derivative of formula VII (Y is H or amino-protecting group) to obtain the acylated compound of formula VIII. The compound of formula I can be prepared by eliminating the protecting group of the compound of formula VIII and if necessary, esterifying the product.
COPYRIGHT: (C)1981,JPO&Japio
JP2203580A 1979-09-13 1980-02-23 Optically active cephalosporin analogue Pending JPS56118084A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2203580A JPS56118084A (en) 1980-02-23 1980-02-23 Optically active cephalosporin analogue
ES495035A ES495035A0 (en) 1979-09-13 1980-09-12 A PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORIN ANALOGS.
NO802713A NO802713L (en) 1979-09-13 1980-09-12 PROCEDURE FOR THE PREPARATION OF RACEMIC OR OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS
DK389080A DK389080A (en) 1979-09-13 1980-09-12 PROCEDURE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPABLE SALTS THEREOF
EP80105492A EP0025602B1 (en) 1979-09-13 1980-09-12 Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them
DE8080105492T DE3069832D1 (en) 1979-09-13 1980-09-12 Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them
CA000360255A CA1178957A (en) 1979-09-13 1980-09-15 Cephalosporin analogs
US06/788,660 US4663450A (en) 1979-10-25 1985-10-17 Optically active cephalosporin analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2203580A JPS56118084A (en) 1980-02-23 1980-02-23 Optically active cephalosporin analogue

Publications (1)

Publication Number Publication Date
JPS56118084A true JPS56118084A (en) 1981-09-16

Family

ID=12071697

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2203580A Pending JPS56118084A (en) 1979-09-13 1980-02-23 Optically active cephalosporin analogue

Country Status (1)

Country Link
JP (1) JPS56118084A (en)

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