JPS56118084A - Optically active cephalosporin analogue - Google Patents
Optically active cephalosporin analogueInfo
- Publication number
- JPS56118084A JPS56118084A JP2203580A JP2203580A JPS56118084A JP S56118084 A JPS56118084 A JP S56118084A JP 2203580 A JP2203580 A JP 2203580A JP 2203580 A JP2203580 A JP 2203580A JP S56118084 A JPS56118084 A JP S56118084A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- optically active
- syn
- gram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (R1 is H, alkyl, alkenyl, alkynyl, etc.; R2 is H, lower alkyl, or lower acyl; R3 is H or ester residue; the H atoms at 6- and 7-position are cis, and OR1 is syn), and its salt.
EXAMPLE: (4S,6R,7S)-7-[2-(2-Amino-4-thiazolyl)-2-syn-methoxyiminoacetamido]-4- hydroxy-1-azabicyclo[4,2,0]oct-2-en-8-one-2-carboxylic acid.
USE: Drug having strong antibacterial activity to Gram-negative bacteria and Gram- positive bacteria.
PROCESS: An optically active isomer of a cephalosporin analogue of formula V-1 is acylated with a reactive derivative of formula VII (Y is H or amino-protecting group) to obtain the acylated compound of formula VIII. The compound of formula I can be prepared by eliminating the protecting group of the compound of formula VIII and if necessary, esterifying the product.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2203580A JPS56118084A (en) | 1980-02-23 | 1980-02-23 | Optically active cephalosporin analogue |
ES495035A ES495035A0 (en) | 1979-09-13 | 1980-09-12 | A PROCEDURE FOR THE PRODUCTION OF CEPHALOSPORIN ANALOGS. |
NO802713A NO802713L (en) | 1979-09-13 | 1980-09-12 | PROCEDURE FOR THE PREPARATION OF RACEMIC OR OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEFEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS |
DK389080A DK389080A (en) | 1979-09-13 | 1980-09-12 | PROCEDURE FOR PREPARING RACEMIC OR OPTICALLY ACTIVE CEPHALOSPORIN ANALOGUE CARBACEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPABLE SALTS THEREOF |
EP80105492A EP0025602B1 (en) | 1979-09-13 | 1980-09-12 | Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them |
DE8080105492T DE3069832D1 (en) | 1979-09-13 | 1980-09-12 | Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them |
CA000360255A CA1178957A (en) | 1979-09-13 | 1980-09-15 | Cephalosporin analogs |
US06/788,660 US4663450A (en) | 1979-10-25 | 1985-10-17 | Optically active cephalosporin analogs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2203580A JPS56118084A (en) | 1980-02-23 | 1980-02-23 | Optically active cephalosporin analogue |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56118084A true JPS56118084A (en) | 1981-09-16 |
Family
ID=12071697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2203580A Pending JPS56118084A (en) | 1979-09-13 | 1980-02-23 | Optically active cephalosporin analogue |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56118084A (en) |
-
1980
- 1980-02-23 JP JP2203580A patent/JPS56118084A/en active Pending
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