JPS5594337A - Method of improving solubility of active compound having biological activity into water and*or lower aliphatic alcohol and novel compound having improved solubility - Google Patents

Method of improving solubility of active compound having biological activity into water and*or lower aliphatic alcohol and novel compound having improved solubility

Info

Publication number
JPS5594337A
JPS5594337A JP145280A JP145280A JPS5594337A JP S5594337 A JPS5594337 A JP S5594337A JP 145280 A JP145280 A JP 145280A JP 145280 A JP145280 A JP 145280A JP S5594337 A JPS5594337 A JP S5594337A
Authority
JP
Japan
Prior art keywords
solubility
water
biological activity
aliphatic alcohol
lower aliphatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP145280A
Other languages
English (en)
Inventor
Meeringu Etogaru
Peeteru Miyuureru Hansu
Resureru Peeteru
Buaaguneru Kuunoo
Teiitsu Herumuuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19792901060 external-priority patent/DE2901060A1/de
Priority claimed from DE19792910356 external-priority patent/DE2910356A1/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS5594337A publication Critical patent/JPS5594337A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP145280A 1979-01-12 1980-01-11 Method of improving solubility of active compound having biological activity into water and*or lower aliphatic alcohol and novel compound having improved solubility Pending JPS5594337A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792901060 DE2901060A1 (de) 1979-01-12 1979-01-12 Verfahren zur verbesserung der loeslichkeit biologisch aktiver wirkstoffe in wasser und niederen aliphatischen alkoholen sowie neue verbindungen mit verbesserter loeslichkeit
DE19792910356 DE2910356A1 (de) 1979-03-16 1979-03-16 Verfahren zur verbesserung der loeslichkeit biologisch aktiver wirkstoffe in wasser und niederen aliphatischen alkoholen sowie neue verbindungen mit verbesserter loeslichkeit

Publications (1)

Publication Number Publication Date
JPS5594337A true JPS5594337A (en) 1980-07-17

Family

ID=25777372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP145280A Pending JPS5594337A (en) 1979-01-12 1980-01-11 Method of improving solubility of active compound having biological activity into water and*or lower aliphatic alcohol and novel compound having improved solubility

Country Status (7)

Country Link
US (1) US4684728A (ja)
EP (1) EP0014263B1 (ja)
JP (1) JPS5594337A (ja)
BR (1) BR8000192A (ja)
DE (1) DE2962754D1 (ja)
DK (1) DK13580A (ja)
IL (1) IL59099A (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0653222U (ja) * 1992-10-23 1994-07-19 節子 相野谷 トランク・ルームの保冷装置
JP2008179653A (ja) * 2004-04-01 2008-08-07 Cardiome Pharma Corp Ｐｅｇ化イオンチャネル調節化合物
JP2017071790A (ja) * 2009-11-03 2017-04-13 コベストロ、ドイチュラント、アクチエンゲゼルシャフトＣｏｖｅｓｔｒｏ Ｄｅｕｔｓｃｈｌａｎｄ Ａｇ 感光性ポリマー組成物における添加剤としてのフルオロウレタン

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581434A (en) * 1982-09-04 1986-04-08 Bayer Aktiengesellschaft Process for increasing the duration of action of agents for combating pests
DE4017439C2 (de) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyethersubstituierte Tumormittel
JPH06506217A (ja) * 1991-03-18 1994-07-14 エンゾン，インコーポレーテッド ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
EP0814809B1 (en) * 1994-12-13 2003-08-13 Euroceltique S.A. Aryl thioxanthines
ATE247655T1 (de) * 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
AU6643200A (en) * 1999-08-18 2001-03-13 American Home Products Corporation Water soluble sdz-rad esters
US6331547B1 (en) 1999-08-18 2001-12-18 American Home Products Corporation Water soluble SDZ RAD esters
EP1379257B1 (en) * 2001-03-23 2009-08-12 Enzon, Inc. Prodrugs of anticancer agents employing substituted aromatic acids
US7838621B2 (en) * 2003-11-04 2010-11-23 Suprapolix B.V. Preparation of supramolecular polymer containing quadruple hydrogen bonding units in the polymer backbone
US7977373B2 (en) 2004-04-01 2011-07-12 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
WO2006138673A2 (en) 2005-06-15 2006-12-28 Cardiome Pharma Corp. Synthetic processes for the preparation of aminocyclohexyl ether compounds
JP5183198B2 (ja) * 2004-07-12 2013-04-17 スープラポリックス ビー．ブイ． 超分子イオノマー
EP1828099B1 (en) 2004-11-18 2020-01-22 Correvio International Sàrl Synthetic process for aminocyclohexyl ether compounds
ES2376888T3 (es) 2005-05-04 2012-03-20 Suprapolix B.V. Materiales supramoleculares activos biológicamente, modulares biorreabsorbibles o biomédicos
DE102005023588A1 (de) * 2005-05-18 2006-11-23 Grünenthal GmbH Salze substituierter Allophansäureester und deren Verwendung in Arzneimitteln
ATE527305T1 (de) 2006-11-20 2011-10-15 Suprapolix Bv Supramolekulare polymere aus niedrigschmelzenden, leicht verarbeitbaren bausteinen
US8628789B2 (en) * 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
US8754213B2 (en) * 2008-07-04 2014-06-17 Suprapolix B.V. High flow supramolecular compounds
KR101820979B1 (ko) 2009-12-30 2018-01-22 쓰리엠 이노베이티브 프로퍼티즈 컴파니 폴리다이오르가노실록산 폴리옥사미드 공중합체의 제조 방법
CN102712750B (zh) 2009-12-30 2014-06-25 3M创新有限公司 具有乙二酰胺基团的含全氟聚醚化合物
WO2011082046A1 (en) 2009-12-30 2011-07-07 3M Innovative Properties Company Copolymers with perfluorpolyether segment and multiple aminooxalylamino groups
WO2011082063A1 (en) 2009-12-30 2011-07-07 3M Innovative Properties Company Copolymers with perfluorpolyether segment and polydiorganosiloxane segment
EP2450394B1 (en) 2010-11-05 2017-06-07 SupraPolix B.V. A process for the preparation of a supramolecular polymer

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US2857261A (en) * 1954-04-27 1958-10-21 Monsanto Chemicals Herbicidal sulfoalkyl esters of phenoxyacetates
US4039576A (en) * 1972-03-28 1977-08-02 Ciba-Geigy Corporation Process for the manufacture of alkoxylated N-methylol ureas
CA1023376A (en) * 1972-08-04 1977-12-27 Hermann O. Wirth Hydrophilic and difficultly volatile biocidal triorganometallic compounds
CS179484B1 (en) * 1972-08-18 1977-11-30 Otto Wichterle Method of producing polymeric acrylated or methacrylated carriers of biological active compounds
FR2264522A1 (en) * 1974-03-22 1975-10-17 Rouchy Maurice Vitamin F cpds having surface active properties - comprise linoleic, linolenic and arachidonic acid radical joined via O or N to polyalcohols
US4178427A (en) * 1976-05-05 1979-12-11 Texaco Development Corp. Polyether urea epoxy curing agent
US4154724A (en) * 1976-06-28 1979-05-15 Texaco Development Corp. Polyether polyureides and resinous compositions therefrom
DE2645079A1 (de) * 1976-10-06 1978-04-13 Bayer Ernst Polymere sauerstofftraeger und verfahren zu ihrer herstellung
DE2723248A1 (de) * 1977-05-24 1978-11-30 Bayer Ag Insektizide mittel

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0653222U (ja) * 1992-10-23 1994-07-19 節子 相野谷 トランク・ルームの保冷装置
JP2008179653A (ja) * 2004-04-01 2008-08-07 Cardiome Pharma Corp Ｐｅｇ化イオンチャネル調節化合物
JP2017071790A (ja) * 2009-11-03 2017-04-13 コベストロ、ドイチュラント、アクチエンゲゼルシャフトＣｏｖｅｓｔｒｏ Ｄｅｕｔｓｃｈｌａｎｄ Ａｇ 感光性ポリマー組成物における添加剤としてのフルオロウレタン

Also Published As

Publication number Publication date
DK13580A (da) 1980-07-13
EP0014263A2 (de) 1980-08-20
DE2962754D1 (en) 1982-06-24
IL59099A0 (en) 1980-05-30
EP0014263A3 (en) 1980-09-17
EP0014263B1 (de) 1982-05-05
US4684728A (en) 1987-08-04
BR8000192A (pt) 1980-10-21
IL59099A (en) 1984-03-30

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