JPS5587777A - Pyrimidine derivative, its preparation and antitumorigenic agent - Google Patents
Pyrimidine derivative, its preparation and antitumorigenic agentInfo
- Publication number
- JPS5587777A JPS5587777A JP15996278A JP15996278A JPS5587777A JP S5587777 A JPS5587777 A JP S5587777A JP 15996278 A JP15996278 A JP 15996278A JP 15996278 A JP15996278 A JP 15996278A JP S5587777 A JPS5587777 A JP S5587777A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- alkyl
- pyrimidine derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002622 anti-tumorigenesis Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 1W30C aliphatic acyl Chemical group 0.000 abstract 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229960002949 fluorouracil Drugs 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- NRDQFWXVTPZZAZ-UHFFFAOYSA-N butyl carbonochloridate Chemical compound CCCCOC(Cl)=O NRDQFWXVTPZZAZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15996278A JPS5587777A (en) | 1978-12-27 | 1978-12-27 | Pyrimidine derivative, its preparation and antitumorigenic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15996278A JPS5587777A (en) | 1978-12-27 | 1978-12-27 | Pyrimidine derivative, its preparation and antitumorigenic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5587777A true JPS5587777A (en) | 1980-07-02 |
| JPS6337787B2 JPS6337787B2 (en, 2012) | 1988-07-27 |
Family
ID=15704965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15996278A Granted JPS5587777A (en) | 1978-12-27 | 1978-12-27 | Pyrimidine derivative, its preparation and antitumorigenic agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5587777A (en, 2012) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60184066A (ja) * | 1984-03-02 | 1985-09-19 | Sagami Chem Res Center | ５−フルオロ−６−クロロウラシル誘導体及びその製造方法 |
| EP0877022A1 (en) * | 1997-05-09 | 1998-11-11 | Herbos d.d. | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
| US6410546B1 (en) | 1997-04-07 | 2002-06-25 | Triangle Pharmaceuticals, Inc. | Use of MKC-442 in combination with other antiviral agents |
| USRE37979E1 (en) | 1989-09-29 | 2003-02-04 | Mitsubishi Chemical Corporation | Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof |
| JP2003505451A (ja) * | 1999-07-22 | 2003-02-12 | ブラッコ イメージング エッセ ピ ア | セラミド類似体類、それらの調製方法及び抗腫瘍剤としてのそれらの使用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6223723A (ja) * | 1985-07-24 | 1987-01-31 | Canon Inc | 射出圧縮成形方法 |
-
1978
- 1978-12-27 JP JP15996278A patent/JPS5587777A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6223723A (ja) * | 1985-07-24 | 1987-01-31 | Canon Inc | 射出圧縮成形方法 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60184066A (ja) * | 1984-03-02 | 1985-09-19 | Sagami Chem Res Center | ５−フルオロ−６−クロロウラシル誘導体及びその製造方法 |
| USRE37979E1 (en) | 1989-09-29 | 2003-02-04 | Mitsubishi Chemical Corporation | Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof |
| US6410546B1 (en) | 1997-04-07 | 2002-06-25 | Triangle Pharmaceuticals, Inc. | Use of MKC-442 in combination with other antiviral agents |
| EP0877022A1 (en) * | 1997-05-09 | 1998-11-11 | Herbos d.d. | Synthesis of the sulfonylpyrimidine derivatives with anticancer activity |
| JP2003505451A (ja) * | 1999-07-22 | 2003-02-12 | ブラッコ イメージング エッセ ピ ア | セラミド類似体類、それらの調製方法及び抗腫瘍剤としてのそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6337787B2 (en, 2012) | 1988-07-27 |
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