JPS5566562A - Novel imidazole derivative and antidepressant containing the same - Google Patents
Novel imidazole derivative and antidepressant containing the sameInfo
- Publication number
- JPS5566562A JPS5566562A JP13932578A JP13932578A JPS5566562A JP S5566562 A JPS5566562 A JP S5566562A JP 13932578 A JP13932578 A JP 13932578A JP 13932578 A JP13932578 A JP 13932578A JP S5566562 A JPS5566562 A JP S5566562A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- amino
- methyl
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000935 antidepressant agent Substances 0.000 title abstract 3
- 229940005513 antidepressants Drugs 0.000 title abstract 3
- 230000001430 anti-depressive effect Effects 0.000 title abstract 2
- 150000002460 imidazoles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- JBCFJMYPJJWIRG-UHFFFAOYSA-N 1,3-oxazole-4-carboxylic acid Chemical class OC(=O)C1=COC=N1 JBCFJMYPJJWIRG-UHFFFAOYSA-N 0.000 abstract 1
- HJQHINQZCOXIGG-UHFFFAOYSA-N 1-(3,4-dimethylphenyl)-2-methylimidazole Chemical compound CC1=NC=CN1C1=CC=C(C)C(C)=C1 HJQHINQZCOXIGG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000155 melt Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13932578A JPS5566562A (en) | 1978-11-14 | 1978-11-14 | Novel imidazole derivative and antidepressant containing the same |
| US06/093,469 US4301169A (en) | 1978-11-14 | 1979-11-13 | Novel imidazole compound and anti-depressing agent containing the same |
| GB7939283A GB2044754B (en) | 1978-11-14 | 1979-11-13 | Imidazoles |
| SE7909371A SE447653B (sv) | 1978-11-14 | 1979-11-13 | Imidazolderivat samt farmaceutisk komposition innehallande sadant derivat |
| IT27268/79A IT1127223B (it) | 1978-11-14 | 1979-11-14 | Composto dell'imidazolo e medicamento contro gli stati depressivi contenente detto composto |
| FR7928099A FR2441616B1 (fr) | 1978-11-14 | 1979-11-14 | Nouvel imidazole, procede pour sa preparation et son application therapeutique |
| BE2/58208A BE880020A (fr) | 1978-11-14 | 1979-11-14 | Nouveau compose d'imidazole et agent antidepressif contenant ce compose |
| NL7908331A NL7908331A (nl) | 1978-11-14 | 1979-11-14 | Imidazoolderivaten met anti-depressieve werking. |
| DE19792946020 DE2946020A1 (de) | 1978-11-14 | 1979-11-14 | Imidazolverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| CH1014979A CH642635A5 (fr) | 1978-11-14 | 1979-11-14 | Derives de l'imidazole, procedes pour leur preparation et compositions medicamenteuses contenant ces derives. |
| CA339,861A CA1126272A (fr) | 1978-11-14 | 1979-11-14 | Compose d'imidazole et agent anti-depresseur le contenant |
| US06/252,674 US4402966A (en) | 1978-11-14 | 1981-04-09 | Acylaminophenyl imidazoles and anti-depressing agent containing the same |
| US06/469,548 US4533669A (en) | 1978-11-14 | 1983-02-25 | Anti-depressant imidazoles |
| US06/741,935 US4602031A (en) | 1978-11-14 | 1985-06-06 | Anti-depressant imidazoles, compositions and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13932578A JPS5566562A (en) | 1978-11-14 | 1978-11-14 | Novel imidazole derivative and antidepressant containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5566562A true JPS5566562A (en) | 1980-05-20 |
| JPS6140227B2 JPS6140227B2 (fr) | 1986-09-08 |
Family
ID=15242675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13932578A Granted JPS5566562A (en) | 1978-11-14 | 1978-11-14 | Novel imidazole derivative and antidepressant containing the same |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5566562A (fr) |
| BE (1) | BE880020A (fr) |
-
1978
- 1978-11-14 JP JP13932578A patent/JPS5566562A/ja active Granted
-
1979
- 1979-11-14 BE BE2/58208A patent/BE880020A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE880020A (fr) | 1980-03-03 |
| JPS6140227B2 (fr) | 1986-09-08 |
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