JPS5545644A - 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4'-dideoxykanamycin b and their preparation - Google Patents

6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4'-dideoxykanamycin b and their preparation

Info

Publication number
JPS5545644A
JPS5545644A JP11908878A JP11908878A JPS5545644A JP S5545644 A JPS5545644 A JP S5545644A JP 11908878 A JP11908878 A JP 11908878A JP 11908878 A JP11908878 A JP 11908878A JP S5545644 A JPS5545644 A JP S5545644A
Authority
JP
Japan
Prior art keywords
alkyl
dideoxykanamycin
compound
bacteria
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11908878A
Other languages
Japanese (ja)
Other versions
JPS631317B2 (en
Inventor
Hamao Umezawa
Shinichi Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP11908878A priority Critical patent/JPS5545644A/en
Publication of JPS5545644A publication Critical patent/JPS5545644A/en
Publication of JPS631317B2 publication Critical patent/JPS631317B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:6'-C-alkyl-3'-dexykanamycin B, 6'-C-alkyl-3',4'-dideoxykanamycin B and their acid addition salts, of the formula I (R is H or OH; one of R1 and R2 is H and the other is 1W6C alkyl).
EXAMPLE: 6'(S)-C-Methyl-3',4'-dideoxykanamycin B.
USE: Remedy for infectious diseases caused by various gram-positive and gram-negative bacteria including resistant-bacteria. Inhibits the growth of resistant-bacteria having 6'-acetyl transferase.
PROCESS: The compound I is prepared by (1) reacting a compound II (D, G are H, etc.; E is an amino-protecting group) with ninhydrin, (2) reacting the resulting compound III (novel) with a compound IV (R1a is 1W6C lower alkylene), (3) reducing the product with a metal hydride in the presence of an ammonium salt, and eliminating the protecting group optionally after separating the stereo isomers.
COPYRIGHT: (C)1980,JPO&Japio
JP11908878A 1978-09-29 1978-09-29 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4'-dideoxykanamycin b and their preparation Granted JPS5545644A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11908878A JPS5545644A (en) 1978-09-29 1978-09-29 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4'-dideoxykanamycin b and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11908878A JPS5545644A (en) 1978-09-29 1978-09-29 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4'-dideoxykanamycin b and their preparation

Publications (2)

Publication Number Publication Date
JPS5545644A true JPS5545644A (en) 1980-03-31
JPS631317B2 JPS631317B2 (en) 1988-01-12

Family

ID=14752586

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11908878A Granted JPS5545644A (en) 1978-09-29 1978-09-29 6'-c-alkyl-3'-deoxykanamycin b or 6'-c-alkyl-3',4'-dideoxykanamycin b and their preparation

Country Status (1)

Country Link
JP (1) JPS5545644A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506550A (en) * 1990-02-05 1992-11-12 ローディア　フィルテック　アーゲー Single fiber high-speed spinning method and device and single fiber made thereby

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506550A (en) * 1990-02-05 1992-11-12 ローディア　フィルテック　アーゲー Single fiber high-speed spinning method and device and single fiber made thereby

Also Published As

Publication number Publication date
JPS631317B2 (en) 1988-01-12

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