JPS5543013A - Macrolide antibiotic n-1 and its preparation - Google Patents
Macrolide antibiotic n-1 and its preparationInfo
- Publication number
- JPS5543013A JPS5543013A JP11550878A JP11550878A JPS5543013A JP S5543013 A JPS5543013 A JP S5543013A JP 11550878 A JP11550878 A JP 11550878A JP 11550878 A JP11550878 A JP 11550878A JP S5543013 A JPS5543013 A JP S5543013A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyl group
- actinomycetes
- formula
- streptomyces
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The compound of formula I.
USE: Medicines effective against bacteria and mycoplasma resistant to the well-known macrolide antibiotics.
PROCESS: A culture of actinomycetes, which belong to the genus Streptomyces, is brought into contact with mycaminosyltylonolide as a substrate under aerobic conditions to produce the substance N-1 of formula I. The actinomycetes have the ability to acetylate the hydroxyl group at the 3-position of the 16-membered macrolide ring, to link the hydroxyl group at the 4'-position to the mycarose (M), and to convert the hydroxyl group at the 4"-position of M into the isoraleryl group, and Streptomyces thermotoleraus ATCC11416 may be cited. The bacteira are cultured in a liquid medium by the shaking or spinner culture method.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53115508A JPS6016960B2 (en) | 1978-09-20 | 1978-09-20 | Macrolide antibiotic N-1 and its manufacturing method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53115508A JPS6016960B2 (en) | 1978-09-20 | 1978-09-20 | Macrolide antibiotic N-1 and its manufacturing method |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5543013A true JPS5543013A (en) | 1980-03-26 |
JPS6016960B2 JPS6016960B2 (en) | 1985-04-30 |
Family
ID=14664248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53115508A Expired JPS6016960B2 (en) | 1978-09-20 | 1978-09-20 | Macrolide antibiotic N-1 and its manufacturing method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6016960B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5731699A (en) * | 1980-06-12 | 1982-02-20 | Lilly Co Eli | Macrolide antibiotic |
JPS58219197A (en) * | 1982-06-15 | 1983-12-20 | Sanraku Inc | Derivative of macrolide antibiotic |
-
1978
- 1978-09-20 JP JP53115508A patent/JPS6016960B2/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5731699A (en) * | 1980-06-12 | 1982-02-20 | Lilly Co Eli | Macrolide antibiotic |
JPS58219197A (en) * | 1982-06-15 | 1983-12-20 | Sanraku Inc | Derivative of macrolide antibiotic |
JPH039919B2 (en) * | 1982-06-15 | 1991-02-12 | Merushan Kk |
Also Published As
Publication number | Publication date |
---|---|
JPS6016960B2 (en) | 1985-04-30 |
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