JPS5498793A - Deacylated antibiotic and its preparation - Google Patents
Deacylated antibiotic and its preparationInfo
- Publication number
- JPS5498793A JPS5498793A JP807877A JP807877A JPS5498793A JP S5498793 A JPS5498793 A JP S5498793A JP 807877 A JP807877 A JP 807877A JP 807877 A JP807877 A JP 807877A JP S5498793 A JPS5498793 A JP S5498793A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- deacylated
- antibiotic
- antibiotics
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A deacylated antibiotic of formula I: (R1 is H, acetyl, or propionyl group) and its salt.
EXAMPLE: Isoleucomycin V(R1 is H in the formula I).
USE: A starting material for 13-acyl antibiotics, capable of giving the 13-acyl antibiotics having a good antibacterial spectrum and concentration in the blood free from bitterness by acylating OH groups at the 13- and 4"-positions of the compound of formula I.
PROCESS: Esterase-producing bacteria, e.g. Nocardia sp., FERM-P No. 2019, which fall under the genus Nocardia or Stuphylotrichum, are cultured in a liquid medium at 27W32°C for 2W5 days, and the cultured or treated product is reacted with an autibiotic of formula II: (R2 is acetyl, propionyl, butyryl, or isovaleryl group) in an aqueous solution at pH7W10, preferably 9, at 37°C for 30 min W 3 days to decompose the ester group at the 4"-position, and the fittrate is extracted with benzene to give the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP807877A JPS5498793A (en) | 1977-01-27 | 1977-01-27 | Deacylated antibiotic and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP807877A JPS5498793A (en) | 1977-01-27 | 1977-01-27 | Deacylated antibiotic and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5498793A true JPS5498793A (en) | 1979-08-03 |
Family
ID=11683292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP807877A Pending JPS5498793A (en) | 1977-01-27 | 1977-01-27 | Deacylated antibiotic and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5498793A (en) |
-
1977
- 1977-01-27 JP JP807877A patent/JPS5498793A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5615299A (en) | Rhodomycin group antibiotic and its preparation | |
JPS5592387A (en) | Antibiotic substance tm-531 | |
JPS56125335A (en) | 1,4-naphthoquinone derivative, its preparation, and its use | |
JPS5661398A (en) | Substance dc-45 and its preparation | |
JPS5498793A (en) | Deacylated antibiotic and its preparation | |
JPS57170189A (en) | Dc-52 and its preparation | |
JPS54148793A (en) | Novel 3"-acylated macrolide antibiotic | |
Zhdanovich et al. | Isolation of the new antibiotic variamycin B from the biosynthetic products of a Streptomyces olivovariabilis sp. nov. culture | |
JPS5466679A (en) | Novel antibiotic substance fortimicin kf and fortimicin kg, and their preparation | |
JPS57105194A (en) | Novel antibiotic xk-210 and its preparation | |
JPS5687595A (en) | Novel bioactive substance herbimycin b, its preparation, and agricultural and horticultural agent containing said substance as effective component | |
JPS5523909A (en) | Novel substance uaa-3 and its preparation | |
JPS55149297A (en) | Antibiotic herbicidin c, e, f, and g and its preparation | |
FR2233044A1 (en) | L-trans-2-amino-4-(2-aminoethoxy)-3-butenoic acid - antimicrobial antiprotozoal, anthelmintic agent | |
JPS5640698A (en) | Preparation of fortimicin a | |
JPS54141702A (en) | Antibiotic malioxamycin, its preparation, and antibacterials comprising it as active component | |
JPS5511558A (en) | Preparation of novel 3"-acylated macrolide antibiotic | |
JPS5569597A (en) | Peptide derivative and its preparation | |
JPS54160795A (en) | Preparation of gentamicin c/a | |
JPS5677296A (en) | Tryptophane derivative and its preparation | |
JPS57114547A (en) | Anthracycline antibiotic substance and its preparation | |
JPS54145638A (en) | Novel derivative of xk-62-2 | |
JPS5782376A (en) | Novel antibiotic substance saphenamycin and its preparation | |
GB2111498A (en) | Method of preparing 23-monoesters of omt and dmt | |
JPS55136298A (en) | Preparation of 3"-acylated macrolide antibiotic |