JPS5498793A - Deacylated antibiotic and its preparation - Google Patents

Deacylated antibiotic and its preparation

Info

Publication number
JPS5498793A
JPS5498793A JP807877A JP807877A JPS5498793A JP S5498793 A JPS5498793 A JP S5498793A JP 807877 A JP807877 A JP 807877A JP 807877 A JP807877 A JP 807877A JP S5498793 A JPS5498793 A JP S5498793A
Authority
JP
Japan
Prior art keywords
formula
deacylated
antibiotic
antibiotics
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP807877A
Other languages
Japanese (ja)
Inventor
Hideo Sakakibara
Toshiyuki Watanabe
Osamu Okegawa
Yutaka Sato
Tsutomu Yamaguchi
Satoshi Omura
Tetsuo Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP807877A priority Critical patent/JPS5498793A/en
Publication of JPS5498793A publication Critical patent/JPS5498793A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A deacylated antibiotic of formula I: (R1 is H, acetyl, or propionyl group) and its salt.
EXAMPLE: Isoleucomycin V(R1 is H in the formula I).
USE: A starting material for 13-acyl antibiotics, capable of giving the 13-acyl antibiotics having a good antibacterial spectrum and concentration in the blood free from bitterness by acylating OH groups at the 13- and 4"-positions of the compound of formula I.
PROCESS: Esterase-producing bacteria, e.g. Nocardia sp., FERM-P No. 2019, which fall under the genus Nocardia or Stuphylotrichum, are cultured in a liquid medium at 27W32°C for 2W5 days, and the cultured or treated product is reacted with an autibiotic of formula II: (R2 is acetyl, propionyl, butyryl, or isovaleryl group) in an aqueous solution at pH7W10, preferably 9, at 37°C for 30 min W 3 days to decompose the ester group at the 4"-position, and the fittrate is extracted with benzene to give the compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP807877A 1977-01-27 1977-01-27 Deacylated antibiotic and its preparation Pending JPS5498793A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP807877A JPS5498793A (en) 1977-01-27 1977-01-27 Deacylated antibiotic and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP807877A JPS5498793A (en) 1977-01-27 1977-01-27 Deacylated antibiotic and its preparation

Publications (1)

Publication Number Publication Date
JPS5498793A true JPS5498793A (en) 1979-08-03

Family

ID=11683292

Family Applications (1)

Application Number Title Priority Date Filing Date
JP807877A Pending JPS5498793A (en) 1977-01-27 1977-01-27 Deacylated antibiotic and its preparation

Country Status (1)

Country Link
JP (1) JPS5498793A (en)

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