JPS5536424A - Alkaliprotease-inhibiting substance - Google Patents

Alkaliprotease-inhibiting substance

Info

Publication number
JPS5536424A
JPS5536424A JP10982078A JP10982078A JPS5536424A JP S5536424 A JPS5536424 A JP S5536424A JP 10982078 A JP10982078 A JP 10982078A JP 10982078 A JP10982078 A JP 10982078A JP S5536424 A JPS5536424 A JP S5536424A
Authority
JP
Japan
Prior art keywords
reaction
alkaliprotease
inhibiting substance
streptomyces
soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10982078A
Other languages
Japanese (ja)
Other versions
JPS5652032B2 (en
Inventor
Sawao Murao
Kenichi Fukuhara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP10982078A priority Critical patent/JPS5536424A/en
Publication of JPS5536424A publication Critical patent/JPS5536424A/en
Publication of JPS5652032B2 publication Critical patent/JPS5652032B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

NEW MATERIAL:An alkaliprotease-inhibiting substance. Elemental analysis, C 58.3%, H 7.2%, N 15.3%; molecular weight, about 600; melting point, 208W 209°C; solubility, sparingly soluble in water, soluble in dimethyl sulfoxide, etc.; color reactions, positive to Leyden-smith reaction, Sakaguchi reaction, etc., negative to ninhydrin reaction and ehrlich reaction; basic or amphoteric; white powder.
USE: Inhibitor of alkaliprotease, chymotrypsin, papain, and fuchsine. Remedy for various shocks, pancreatitis, haemorrhagia, etc.
PROCESS: The objective substance is prepared by culturing bacteria belonging to Streptomyces genus and capable of producing β-MARI, e.g. Streptomyces nigrescens (WT27, FERM-P No.4131), in a conventional nutrient medium under aerobic conditions, adsorbing the filtrate of the medium, e.g. by adsorption chromatography, eluting with butanol, etc., and purifying the eluate.
COPYRIGHT: (C)1980,JPO&Japio
JP10982078A 1978-09-08 1978-09-08 Alkaliprotease-inhibiting substance Granted JPS5536424A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10982078A JPS5536424A (en) 1978-09-08 1978-09-08 Alkaliprotease-inhibiting substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10982078A JPS5536424A (en) 1978-09-08 1978-09-08 Alkaliprotease-inhibiting substance

Publications (2)

Publication Number Publication Date
JPS5536424A true JPS5536424A (en) 1980-03-14
JPS5652032B2 JPS5652032B2 (en) 1981-12-09

Family

ID=14520026

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10982078A Granted JPS5536424A (en) 1978-09-08 1978-09-08 Alkaliprotease-inhibiting substance

Country Status (1)

Country Link
JP (1) JPS5536424A (en)

Also Published As

Publication number Publication date
JPS5652032B2 (en) 1981-12-09

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