JPS5530652A - Latex sensitive to antibody of human beta2-microglobulin for quantitizing human beta2-microglobulin and its composite - Google Patents

Latex sensitive to antibody of human beta2-microglobulin for quantitizing human beta2-microglobulin and its composite

Info

Publication number
JPS5530652A
JPS5530652A JP10389078A JP10389078A JPS5530652A JP S5530652 A JPS5530652 A JP S5530652A JP 10389078 A JP10389078 A JP 10389078A JP 10389078 A JP10389078 A JP 10389078A JP S5530652 A JPS5530652 A JP S5530652A
Authority
JP
Japan
Prior art keywords
microglobulin
antibody
human
latex particles
human beta2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10389078A
Other languages
Japanese (ja)
Inventor
Tetsuo Tomiyama
Taku Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seikagaku Corp
Original Assignee
Seikagaku Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Corp filed Critical Seikagaku Corp
Priority to JP10389078A priority Critical patent/JPS5530652A/en
Priority to SE7907118A priority patent/SE446130B/en
Priority to CH776879A priority patent/CH645727A5/en
Priority to DE19792934756 priority patent/DE2934756C2/en
Priority to GB7929797A priority patent/GB2030294B/en
Priority to FR7921528A priority patent/FR2435039A1/en
Publication of JPS5530652A publication Critical patent/JPS5530652A/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

Abstract

PURPOSE: To make it possible to simply and highly sensitively quantitize the human β2-microglobulin for inspecting the trouble in a microurethra by carrying the human β2-microglobulin antibody in the surface of latex particles.
CONSTITUTION: An animal, which can produce an antibody from a material such as the urine of a patient while using human β2-microglobulin as an antigen, us used to produce the human β2-microglobulin. The latex particles, which preferably have a narrow range of diameter distribution of 0.01 to 10μ and specific weight of 0.9 to 1.4, especially polystyrene latex particles and the aforementioned antibody are stirred and brought into contact in a buffer liquid. After the reaction, the latex sensitive to the antibody is rinsed and seuspended and reserved in a buffer agent which is prepared by adding 1.2 to 4.0wt. parts of stabilizing agent such as glycine to 1wt. part of the latex particles.
COPYRIGHT: (C)1980,JPO&Japio
JP10389078A 1978-08-28 1978-08-28 Latex sensitive to antibody of human beta2-microglobulin for quantitizing human beta2-microglobulin and its composite Pending JPS5530652A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP10389078A JPS5530652A (en) 1978-08-28 1978-08-28 Latex sensitive to antibody of human beta2-microglobulin for quantitizing human beta2-microglobulin and its composite
SE7907118A SE446130B (en) 1978-08-28 1979-08-27 COMPOSITION FOR DETERMINATION OF HUMAN BETA? 712-MICROGLOBULIN, PROCEDURE FOR PREPARING THEREOF AND SETTING FOR DETERMINING HUMAN BETA? 712-MICROGLOBULIN
CH776879A CH645727A5 (en) 1978-08-28 1979-08-27 PREPARATION FOR DETERMINING HUMAN BETA-2-MICROGLOBULIN, METHOD FOR THE PRODUCTION THEREOF AND ITS USE.
DE19792934756 DE2934756C2 (en) 1978-08-28 1979-08-28 Composition for the determination of beta 2 -human microglobulin and process for its preparation and its application
GB7929797A GB2030294B (en) 1978-08-28 1979-08-28 Composition for determination of human b-microglobulin process for its preparation and its use
FR7921528A FR2435039A1 (en) 1978-08-28 1979-08-28 COMPOSITION FOR DETERMINING HUMAN MICROGLOBULIN-B2, METHOD FOR ITS PREPARATION AND ITS USE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10389078A JPS5530652A (en) 1978-08-28 1978-08-28 Latex sensitive to antibody of human beta2-microglobulin for quantitizing human beta2-microglobulin and its composite

Publications (1)

Publication Number Publication Date
JPS5530652A true JPS5530652A (en) 1980-03-04

Family

ID=14366013

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10389078A Pending JPS5530652A (en) 1978-08-28 1978-08-28 Latex sensitive to antibody of human beta2-microglobulin for quantitizing human beta2-microglobulin and its composite

Country Status (6)

Country Link
JP (1) JPS5530652A (en)
CH (1) CH645727A5 (en)
DE (1) DE2934756C2 (en)
FR (1) FR2435039A1 (en)
GB (1) GB2030294B (en)
SE (1) SE446130B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60115864A (en) * 1983-10-26 1985-06-22 インタ−ナシヨナル・リモ−ト・イメ−ジング・システムズ、インコ−ポレ−テツド Method of determining origin of particle in urine
JPH06104122B1 (en) * 1985-09-19 1994-12-21
CN108872590A (en) * 2018-06-29 2018-11-23 宁波海壹生物科技有限公司 The kit of β2-microglobulin in serum and urine specimen can be detected simultaneously
CN109975550A (en) * 2018-12-29 2019-07-05 宁波普瑞柏生物技术股份有限公司 Eliminate the method and kit of hook effect in β2-microglobulin detection

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59224565A (en) * 1983-04-28 1984-12-17 Morinaga Milk Ind Co Ltd Reagent for detecting antigen
US5175113A (en) * 1986-01-16 1992-12-29 Novo Nordisk A/S Modified β2 -microglobulin
DK160944C (en) * 1986-01-16 1991-10-21 Novo Industri As MODIFIED BETA2 MICROGLOBULINES AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE
DE3776967D1 (en) * 1986-05-30 1992-04-09 Kanegafuchi Chemical Ind Sorbents for beta 2-microglobulin and immunoglobulin L-chain.
NL8602915A (en) * 1986-11-17 1988-06-16 Innogenetics Nv METHOD AND DIAGNOSTIC AGENT FOR DIAGNOSTIZING AND / OR PROSPECTIVE INJURY IN ALIGNMENT OF PULMONARY MICROCIRCULATION.
US20020164818A1 (en) 1995-05-23 2002-11-07 Gruber Karl F. Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3088875A (en) * 1959-10-27 1963-05-07 Hyland Lab Immunological diagnostics utilizing polystyrene latex particles of 0.15 to 0.25 micron
NL125235C (en) * 1965-04-15
GB1384399A (en) * 1971-02-01 1975-02-19 Hoffmann La Roche Automated method of obtaining serological data

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60115864A (en) * 1983-10-26 1985-06-22 インタ−ナシヨナル・リモ−ト・イメ−ジング・システムズ、インコ−ポレ−テツド Method of determining origin of particle in urine
JPH06104122B1 (en) * 1985-09-19 1994-12-21
CN108872590A (en) * 2018-06-29 2018-11-23 宁波海壹生物科技有限公司 The kit of β2-microglobulin in serum and urine specimen can be detected simultaneously
CN109975550A (en) * 2018-12-29 2019-07-05 宁波普瑞柏生物技术股份有限公司 Eliminate the method and kit of hook effect in β2-microglobulin detection

Also Published As

Publication number Publication date
FR2435039A1 (en) 1980-03-28
FR2435039B1 (en) 1984-02-24
SE446130B (en) 1986-08-11
CH645727A5 (en) 1984-10-15
SE7907118L (en) 1980-02-29
DE2934756A1 (en) 1980-03-13
GB2030294A (en) 1980-04-02
DE2934756C2 (en) 1984-11-08
GB2030294B (en) 1983-03-02

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