JPS5520724A - Novel preparation of 7-substituted or unsubstituted amino-3-substituted thiomethyl-1-oxa or methylene-1- dithiacephemcarboxylic acid - Google Patents

Novel preparation of 7-substituted or unsubstituted amino-3-substituted thiomethyl-1-oxa or methylene-1- dithiacephemcarboxylic acid

Info

Publication number
JPS5520724A
JPS5520724A JP9361278A JP9361278A JPS5520724A JP S5520724 A JPS5520724 A JP S5520724A JP 9361278 A JP9361278 A JP 9361278A JP 9361278 A JP9361278 A JP 9361278A JP S5520724 A JPS5520724 A JP S5520724A
Authority
JP
Japan
Prior art keywords
compound
acid
substituted
formula
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9361278A
Other languages
Japanese (ja)
Inventor
Isamu Saikawa
Shuntaro Takano
Kaishu Momoi
Isamu Takakura
Seietsu Kuroda
Kiyoshi Tanaka
Masanobu Hayashi
Fumihide Nagahashi
Chiaki Kutani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP9361278A priority Critical patent/JPS5520724A/en
Publication of JPS5520724A publication Critical patent/JPS5520724A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare the desired high-purity compound for use an intermediate of a corresponding cephalosporin compound of a thiol compound in a high yield through an industrially ready process, by the 3-position conversion reaction of a compound with the thiol compound in an organic solvent in the presence of an acid or an acid complex compound.
CONSTITUTION: A compound shown by the formula I (R1 is H or alkoxy; R2 is NH2 or amino-protecting group; X is acyloxy or carbamoyloxy; Y is -O- or -CH2-; the dotted line is the ring is a double bond between 2- and 3-positions or 3- and 4-positions), its derivative at the position of carboxyl group, or its salt, is reacted with a compound shown by the formula II (R3 is an organic group, e.g., alkyl) or its salt in an organic solvent preferably in an anhydrous state in the presence of not less than an equimolar amount of an acid or an acid complex compound, e.g., trifluoroboric acid or diethyl ether complex salt, based on the compound shown by the formula I, to prepare the desired compound shown by the formula II, its derivative wherein the carboxyl group is replaced, or its salt.
COPYRIGHT: (C)1980,JPO&Japio
JP9361278A 1978-08-02 1978-08-02 Novel preparation of 7-substituted or unsubstituted amino-3-substituted thiomethyl-1-oxa or methylene-1- dithiacephemcarboxylic acid Pending JPS5520724A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9361278A JPS5520724A (en) 1978-08-02 1978-08-02 Novel preparation of 7-substituted or unsubstituted amino-3-substituted thiomethyl-1-oxa or methylene-1- dithiacephemcarboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9361278A JPS5520724A (en) 1978-08-02 1978-08-02 Novel preparation of 7-substituted or unsubstituted amino-3-substituted thiomethyl-1-oxa or methylene-1- dithiacephemcarboxylic acid

Publications (1)

Publication Number Publication Date
JPS5520724A true JPS5520724A (en) 1980-02-14

Family

ID=14087143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9361278A Pending JPS5520724A (en) 1978-08-02 1978-08-02 Novel preparation of 7-substituted or unsubstituted amino-3-substituted thiomethyl-1-oxa or methylene-1- dithiacephemcarboxylic acid

Country Status (1)

Country Link
JP (1) JPS5520724A (en)

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