JPS5519006A - Preparation of coenzyme q10 - Google Patents
Preparation of coenzyme q10Info
- Publication number
- JPS5519006A JPS5519006A JP5554478A JP5554478A JPS5519006A JP S5519006 A JPS5519006 A JP S5519006A JP 5554478 A JP5554478 A JP 5554478A JP 5554478 A JP5554478 A JP 5554478A JP S5519006 A JPS5519006 A JP S5519006A
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- leucosporidium
- extract
- medium
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare coenzyme Q10, economically, in an industrial scale, in high yield, from microbial cells obtained by culturing coenzyme Q10-producing bacteria belonging to Leucosporidium genus in a nutrient medium.
CONSTITUTION: Bacteria such as Leucosporidium frigidum ATCC22029, Leucosporidium scottii IF00736, etc. are cultured in a medium at pH2W8 (pref. 4.5W 7.5) and 5W35°C. The produced bacterial cells are saponified with methanolic alkali solution in the presence of an antioxidant such as pyrogallol, etc. The saponificate is treated with n-heptane or petroleum ether to extract the coenzyme Q10 of formula (n is 10). The extract is purified by adsorption chromatography using silica gel as adsorbent. The coenzyme Q10 is effective to cardiac insufficiency, stenocardia, etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5554478A JPS5519006A (en) | 1978-05-12 | 1978-05-12 | Preparation of coenzyme q10 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5554478A JPS5519006A (en) | 1978-05-12 | 1978-05-12 | Preparation of coenzyme q10 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5519006A true JPS5519006A (en) | 1980-02-09 |
Family
ID=13001646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5554478A Pending JPS5519006A (en) | 1978-05-12 | 1978-05-12 | Preparation of coenzyme q10 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5519006A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2597859A1 (en) * | 1986-04-29 | 1987-10-30 | Europ Composants Electron | PROCESS FOR THE PURIFICATION OF CHAMOTS OF TITANATES OF ALKALINE EARTH METALS |
-
1978
- 1978-05-12 JP JP5554478A patent/JPS5519006A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2597859A1 (en) * | 1986-04-29 | 1987-10-30 | Europ Composants Electron | PROCESS FOR THE PURIFICATION OF CHAMOTS OF TITANATES OF ALKALINE EARTH METALS |
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