JPS55157600A - Purification of estrone - Google Patents
Purification of estroneInfo
- Publication number
- JPS55157600A JPS55157600A JP6582579A JP6582579A JPS55157600A JP S55157600 A JPS55157600 A JP S55157600A JP 6582579 A JP6582579 A JP 6582579A JP 6582579 A JP6582579 A JP 6582579A JP S55157600 A JPS55157600 A JP S55157600A
- Authority
- JP
- Japan
- Prior art keywords
- estrone
- solution
- aromatic hydrocarbon
- crude
- toluene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: Estrone, which has a hormon activity and is used as a starting material for medical preparation, is purified with industrial advantage by dissolving the crude estrone in tetrahydrofuran containing a specific amount of water, filtering, concentrating the solution and treating the concentrate with an aromatic hydrocarbon to crystallize out.
CONSTITUTION: Crude estrone is dissolved in tetrahydrofuran containing 2W14wt% of water and, when undissolved substances remain, the solution is filtered. The resulting solution is combined with an aromatic hydrocarbon such as toluene and concentrated. Or the solution is directly concentrated and the residue is treated with an aromatic hydrocarbon such as toluene to crystallize out estrone. The crystals of estrone are separated and dried under reduced pressure to give the high-purity objective compound.
EFFECT: With no employment of specified devices, purified estrone is obtained in high yield by using about half amount of the solvent required when the conventional process is applied.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6582579A JPS55157600A (en) | 1979-05-28 | 1979-05-28 | Purification of estrone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6582579A JPS55157600A (en) | 1979-05-28 | 1979-05-28 | Purification of estrone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55157600A true JPS55157600A (en) | 1980-12-08 |
JPS6241520B2 JPS6241520B2 (en) | 1987-09-03 |
Family
ID=13298183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6582579A Granted JPS55157600A (en) | 1979-05-28 | 1979-05-28 | Purification of estrone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55157600A (en) |
-
1979
- 1979-05-28 JP JP6582579A patent/JPS55157600A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6241520B2 (en) | 1987-09-03 |
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