JPS55157600A - Purification of estrone - Google Patents

Purification of estrone

Info

Publication number
JPS55157600A
JPS55157600A JP6582579A JP6582579A JPS55157600A JP S55157600 A JPS55157600 A JP S55157600A JP 6582579 A JP6582579 A JP 6582579A JP 6582579 A JP6582579 A JP 6582579A JP S55157600 A JPS55157600 A JP S55157600A
Authority
JP
Japan
Prior art keywords
estrone
solution
aromatic hydrocarbon
crude
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6582579A
Other languages
Japanese (ja)
Other versions
JPS6241520B2 (en
Inventor
Haruo Imai
Tadashi Ohama
Terumi Akaeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP6582579A priority Critical patent/JPS55157600A/en
Publication of JPS55157600A publication Critical patent/JPS55157600A/en
Publication of JPS6241520B2 publication Critical patent/JPS6241520B2/ja
Granted legal-status Critical Current

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Abstract

PURPOSE: Estrone, which has a hormon activity and is used as a starting material for medical preparation, is purified with industrial advantage by dissolving the crude estrone in tetrahydrofuran containing a specific amount of water, filtering, concentrating the solution and treating the concentrate with an aromatic hydrocarbon to crystallize out.
CONSTITUTION: Crude estrone is dissolved in tetrahydrofuran containing 2W14wt% of water and, when undissolved substances remain, the solution is filtered. The resulting solution is combined with an aromatic hydrocarbon such as toluene and concentrated. Or the solution is directly concentrated and the residue is treated with an aromatic hydrocarbon such as toluene to crystallize out estrone. The crystals of estrone are separated and dried under reduced pressure to give the high-purity objective compound.
EFFECT: With no employment of specified devices, purified estrone is obtained in high yield by using about half amount of the solvent required when the conventional process is applied.
COPYRIGHT: (C)1980,JPO&Japio
JP6582579A 1979-05-28 1979-05-28 Purification of estrone Granted JPS55157600A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6582579A JPS55157600A (en) 1979-05-28 1979-05-28 Purification of estrone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6582579A JPS55157600A (en) 1979-05-28 1979-05-28 Purification of estrone

Publications (2)

Publication Number Publication Date
JPS55157600A true JPS55157600A (en) 1980-12-08
JPS6241520B2 JPS6241520B2 (en) 1987-09-03

Family

ID=13298183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6582579A Granted JPS55157600A (en) 1979-05-28 1979-05-28 Purification of estrone

Country Status (1)

Country Link
JP (1) JPS55157600A (en)

Also Published As

Publication number Publication date
JPS6241520B2 (en) 1987-09-03

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