JPS55153789A - Penem-3-carboxylic acid derivative and its preparation - Google Patents

Penem-3-carboxylic acid derivative and its preparation

Info

Publication number
JPS55153789A
JPS55153789A JP4405079A JP4405079A JPS55153789A JP S55153789 A JPS55153789 A JP S55153789A JP 4405079 A JP4405079 A JP 4405079A JP 4405079 A JP4405079 A JP 4405079A JP S55153789 A JPS55153789 A JP S55153789A
Authority
JP
Japan
Prior art keywords
group
alkyl
formula
compound
penem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4405079A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0372630B2 (da
Inventor
Eiji Oki
Sadao Oida
Akira Yoshida
Teruo Hayashi
Shinichi Sugawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP4405079A priority Critical patent/JPS55153789A/ja
Priority to DK154180A priority patent/DK154180A/da
Priority to ZA00802155A priority patent/ZA802155B/xx
Priority to SE8002708A priority patent/SE8002708L/xx
Priority to FI801168A priority patent/FI801168A/fi
Priority to FR8008137A priority patent/FR2453862A1/fr
Priority to GB8012001A priority patent/GB2048261A/en
Priority to DD80220392A priority patent/DD152561A5/de
Priority to AU57291/80A priority patent/AU5729180A/en
Priority to NO80801046A priority patent/NO801046L/no
Priority to PL22339080A priority patent/PL223390A1/xx
Priority to BE0/200208A priority patent/BE882764A/fr
Priority to ES490510A priority patent/ES8202015A1/es
Priority to IT8067576A priority patent/IT8067576A0/it
Priority to NL8002147A priority patent/NL8002147A/xx
Priority to DE19803013997 priority patent/DE3013997A1/de
Publication of JPS55153789A publication Critical patent/JPS55153789A/ja
Publication of JPH0372630B2 publication Critical patent/JPH0372630B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP4405079A 1979-04-11 1979-04-11 Penem-3-carboxylic acid derivative and its preparation Granted JPS55153789A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
JP4405079A JPS55153789A (en) 1979-04-11 1979-04-11 Penem-3-carboxylic acid derivative and its preparation
DK154180A DK154180A (da) 1979-04-11 1980-04-10 Fremgangsmaade til fremstilling af penem-3-carboxylsyrederivatier
ZA00802155A ZA802155B (en) 1979-04-11 1980-04-10 Penem-3-carboxylic acid derivatives, their preparation and use
SE8002708A SE8002708L (sv) 1979-04-11 1980-04-10 Penem-3-karboxisyraderivat
FI801168A FI801168A (fi) 1979-04-11 1980-04-11 Derivater av penem-3-karboxylsyra deras framstaellning och anvaendning
FR8008137A FR2453862A1 (fr) 1979-04-11 1980-04-11 Derives d'acide peneme-3- carboxylique leurs procedes de preparation et leur application en therapeutique
GB8012001A GB2048261A (en) 1979-04-11 1980-04-11 Penem-3-carboxylic acid derivatives, their preparation and use
DD80220392A DD152561A5 (de) 1979-04-11 1980-04-11 Verfahren zur herstellung von penizillinderivaten
AU57291/80A AU5729180A (en) 1979-04-11 1980-04-11 2-((2-aminoethyl)thio)6-(1-hydroxyethyl)penem-3-caroxylic acid
NO80801046A NO801046L (no) 1979-04-11 1980-04-11 Penem-3-karboksylsyrederivater og fremgangsmaate til fremstilling av samme
PL22339080A PL223390A1 (da) 1979-04-11 1980-04-11
BE0/200208A BE882764A (fr) 1979-04-11 1980-04-11 Derives d'acide peneme-3-carboxylique, leurs procedes de preparation et leur application en therapeutique
ES490510A ES8202015A1 (es) 1979-04-11 1980-04-11 Un procedimiento para la preparacion de derivados de penici-lina
IT8067576A IT8067576A0 (it) 1979-04-11 1980-04-11 Derivati dell acido penem 3 carbossilico loro preparazione ed impiego
NL8002147A NL8002147A (nl) 1979-04-11 1980-04-11 Penem-3-carbonzuurderivaten hun bereiding en gebruik.
DE19803013997 DE3013997A1 (de) 1979-04-11 1980-04-11 Penem-3-carbonsaeurederivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4405079A JPS55153789A (en) 1979-04-11 1979-04-11 Penem-3-carboxylic acid derivative and its preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP61020952A Division JPS61210068A (ja) 1986-01-31 1986-01-31 ４−スルホニルアゼチジノン誘導体

Publications (2)

Publication Number Publication Date
JPS55153789A true JPS55153789A (en) 1980-11-29
JPH0372630B2 JPH0372630B2 (da) 1991-11-19

Family

ID=12680777

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4405079A Granted JPS55153789A (en) 1979-04-11 1979-04-11 Penem-3-carboxylic acid derivative and its preparation

Country Status (16)

Country Link
JP (1) JPS55153789A (da)
AU (1) AU5729180A (da)
BE (1) BE882764A (da)
DD (1) DD152561A5 (da)
DE (1) DE3013997A1 (da)
DK (1) DK154180A (da)
ES (1) ES8202015A1 (da)
FI (1) FI801168A (da)
FR (1) FR2453862A1 (da)
GB (1) GB2048261A (da)
IT (1) IT8067576A0 (da)
NL (1) NL8002147A (da)
NO (1) NO801046L (da)
PL (1) PL223390A1 (da)
SE (1) SE8002708L (da)
ZA (1) ZA802155B (da)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56167689A (en) * 1980-04-24 1981-12-23 Beecham Group Ltd Beta-lactam compounds, their manufacture and use
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
US4431654A (en) * 1982-04-05 1984-02-14 Schering Corporation 6-(Hydroxyethyl)-2-[(heterocyclyl or aryl)thioalkylthio]-penem-3-carboxylates
JPS59139386A (ja) * 1983-01-25 1984-08-10 メルク　エンド　カムパニー　インコーポレーテツド ２―置換アルケニルチオ―ペン―２―エム３―カルボキシル酸
JPS59184185A (ja) * 1983-04-04 1984-10-19 シエリング・コ−ポレ−シヨン 新規なペネム化合物、それらを含む医薬組成物およびそれらの製造方法
JPH05310759A (ja) * 1983-01-25 1993-11-22 Merck & Co Inc ２−アルキルチオペン−２−エム−３−カルボキシル酸抗生物質製造中間体
US6900309B1 (en) * 1999-06-15 2005-05-31 Pfizer Inc Purine derivatives

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5857360A (ja) * 1981-10-01 1983-04-05 Ajinomoto Co Inc アゼチジノン誘導体
CA1190236A (en) 1981-10-23 1985-07-09 Edward J.J. Grabowski Antibiotic synthesis
SU1389680A3 (ru) * 1981-12-11 1988-04-15 Фармиталия Карло Эрба С.П.А. (Фирма) Способ получени оптически активных пенемов или их солей с щелочными металлами
GB8321004D0 (en) * 1983-08-04 1983-09-07 Erba Farmitalia Azetidinones
US5075439A (en) * 1990-08-17 1991-12-24 Pfizer Inc. Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor
GB2252769A (en) * 1991-01-18 1992-08-19 Pfizer Improved process for azetidin-2-ones and intermediates therefor
GB9103034D0 (en) * 1991-02-13 1991-03-27 Fujisawa Pharmaceutical Co Processes for preparing carbapenem derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54119486A (en) * 1978-02-02 1979-09-17 Ciba Geigy Ag 66substituted thiaaaza compound
JPS55105686A (en) * 1979-01-10 1980-08-13 Schering Corp Organic compound*its manufacture and medical composition containing it

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54119486A (en) * 1978-02-02 1979-09-17 Ciba Geigy Ag 66substituted thiaaaza compound
JPS55105686A (en) * 1979-01-10 1980-08-13 Schering Corp Organic compound*its manufacture and medical composition containing it

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56167689A (en) * 1980-04-24 1981-12-23 Beecham Group Ltd Beta-lactam compounds, their manufacture and use
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
DE3231596A1 (de) 1981-08-25 1983-03-10 Sankyo Co., Ltd., Tokyo Penem-3-carbonsaeurederivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
JPS6324515B2 (da) * 1981-08-25 1988-05-20 Sankyo Kk
US4431654A (en) * 1982-04-05 1984-02-14 Schering Corporation 6-(Hydroxyethyl)-2-[(heterocyclyl or aryl)thioalkylthio]-penem-3-carboxylates
JPS59139386A (ja) * 1983-01-25 1984-08-10 メルク　エンド　カムパニー　インコーポレーテツド ２―置換アルケニルチオ―ペン―２―エム３―カルボキシル酸
JPH0516433B2 (da) * 1983-01-25 1993-03-04 Merck & Co Inc
JPH05310759A (ja) * 1983-01-25 1993-11-22 Merck & Co Inc ２−アルキルチオペン−２−エム−３−カルボキシル酸抗生物質製造中間体
JPS59184185A (ja) * 1983-04-04 1984-10-19 シエリング・コ−ポレ−シヨン 新規なペネム化合物、それらを含む医薬組成物およびそれらの製造方法
JPH0470316B2 (da) * 1983-04-04 1992-11-10 Schering Plough Corp
US6900309B1 (en) * 1999-06-15 2005-05-31 Pfizer Inc Purine derivatives

Also Published As

Publication number Publication date
IT8067576A0 (it) 1980-04-11
DE3013997A1 (de) 1980-10-30
NL8002147A (nl) 1980-10-14
BE882764A (fr) 1980-10-13
NO801046L (no) 1980-10-13
ES490510A0 (es) 1981-04-16
SE8002708L (sv) 1980-10-12
PL223390A1 (da) 1981-01-30
ES8202015A1 (es) 1981-04-16
JPH0372630B2 (da) 1991-11-19
DD152561B2 (de) 1981-12-02
FR2453862A1 (fr) 1980-11-07
AU5729180A (en) 1980-10-16
ZA802155B (en) 1981-05-27
GB2048261A (en) 1980-12-10
DK154180A (da) 1980-10-12
FI801168A (fi) 1980-10-12
DD152561A5 (de) 1981-12-02

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