JPS55144000A - Preparation of 2-amino-adenosine-3',5'-cyclic phosphoric acid - Google Patents

Preparation of 2-amino-adenosine-3',5'-cyclic phosphoric acid

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Publication number
JPS55144000A
JPS55144000A JP5142279A JP5142279A JPS55144000A JP S55144000 A JPS55144000 A JP S55144000A JP 5142279 A JP5142279 A JP 5142279A JP 5142279 A JP5142279 A JP 5142279A JP S55144000 A JPS55144000 A JP S55144000A
Authority
JP
Japan
Prior art keywords
phosphoric acid
cyclic phosphoric
adenosine
formula
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5142279A
Other languages
Japanese (ja)
Other versions
JPS633877B2 (en
Inventor
Nobuyuki Yamatsugu
Motohiko Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kikkoman Corp
Original Assignee
Kikkoman Corp
Kikkoman Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kikkoman Corp, Kikkoman Shoyu KK filed Critical Kikkoman Corp
Priority to JP5142279A priority Critical patent/JPS55144000A/en
Publication of JPS55144000A publication Critical patent/JPS55144000A/en
Publication of JPS633877B2 publication Critical patent/JPS633877B2/ja
Granted legal-status Critical Current

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Abstract

PURPOSE: To prepare the title compound useful as an anti-allergic agent, central nervous system depressant, blood platelet coagulation inhibitor, and an intermediate of diuretic, carcinostatic agent, etc., economically, in an industrial scale, by reducing an N6-alkoxy derivative.
CONSTITUTION: The objective compound of formula II is prepared by (1) culturing a specific species of bacteria belonging to Microbacterium genus in a medium containing adenine, xylose, etc. and an inorganic phosphate to obtain adenosine-3',5'- cyclic phosphoric acid, (2) oxidizing the product with H2O2, etc., (3) reacting the resulting 2-imino-6-β-3',5'-cyclic phosphoric acid ribofuranosyl (1,2,4-oxadiazolo [2,3-f]purine) salt of formula I (X is halogen) with an alkyl chloride, (4) subjecting the product to the alkali rearrangement reaction to provide a 2-amino-N6-alkoxy- adenosine-3',5'-cyclic phosphoric acid of formula II (R is lower alkyl), and (5) reducing the compound III with hydrogen in the presence of Pd-C catalyst.
COPYRIGHT: (C)1980,JPO&Japio
JP5142279A 1979-04-27 1979-04-27 Preparation of 2-amino-adenosine-3',5'-cyclic phosphoric acid Granted JPS55144000A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5142279A JPS55144000A (en) 1979-04-27 1979-04-27 Preparation of 2-amino-adenosine-3',5'-cyclic phosphoric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5142279A JPS55144000A (en) 1979-04-27 1979-04-27 Preparation of 2-amino-adenosine-3',5'-cyclic phosphoric acid

Publications (2)

Publication Number Publication Date
JPS55144000A true JPS55144000A (en) 1980-11-10
JPS633877B2 JPS633877B2 (en) 1988-01-26

Family

ID=12886480

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5142279A Granted JPS55144000A (en) 1979-04-27 1979-04-27 Preparation of 2-amino-adenosine-3',5'-cyclic phosphoric acid

Country Status (1)

Country Link
JP (1) JPS55144000A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106589030A (en) * 2016-10-28 2017-04-26 南通宏慈药业有限公司 Preparation method of adenosine cyclophosphate oxide impurity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106589030A (en) * 2016-10-28 2017-04-26 南通宏慈药业有限公司 Preparation method of adenosine cyclophosphate oxide impurity

Also Published As

Publication number Publication date
JPS633877B2 (en) 1988-01-26

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