JPS55143982A - Thiophene derivative - Google Patents

Thiophene derivative

Info

Publication number
JPS55143982A
JPS55143982A JP15913479A JP15913479A JPS55143982A JP S55143982 A JPS55143982 A JP S55143982A JP 15913479 A JP15913479 A JP 15913479A JP 15913479 A JP15913479 A JP 15913479A JP S55143982 A JPS55143982 A JP S55143982A
Authority
JP
Japan
Prior art keywords
derivative
formula
thienyl
reacting
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15913479A
Other languages
Japanese (ja)
Other versions
JPS5829952B2 (en
Inventor
Genichi Dobashi
Katsuyuki Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP15913479A priority Critical patent/JPS5829952B2/en
Publication of JPS55143982A publication Critical patent/JPS55143982A/en
Publication of JPS5829952B2 publication Critical patent/JPS5829952B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

NEW MATERIAL:A thiophene derivative of formula I (R is lower alkyl or phenyl).
EXAMPLE: 1-Methylsulfinyl-1-methylthio-2-(2'-thienyl)ethylene.
USE: Industrially useful intermediate of thienyl acetic acid or its derivative which is a chemical modifier for antibiotics such as penicillin and cephalosporin.
PROCESS: The compound I is prepared by reacting an aldehyde of formula II with formaldehyde mercaptal S-oxide of formula III in the presence of a strong base (e.g. alkyl lithium) which exhibits ≥pH10 as 0.1N aqueous solution. The compound I can be converted to thienyl acetic acid or its derivative in high yield, by reacting with water or an alcohol in the presence of a mineral acid.
COPYRIGHT: (C)1980,JPO&Japio
JP15913479A 1979-12-10 1979-12-10 Thiophene derivative Expired JPS5829952B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15913479A JPS5829952B2 (en) 1979-12-10 1979-12-10 Thiophene derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15913479A JPS5829952B2 (en) 1979-12-10 1979-12-10 Thiophene derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP1235476A Division JPS5295657A (en) 1976-02-09 1976-02-09 Furan or thiophen derivatives

Publications (2)

Publication Number Publication Date
JPS55143982A true JPS55143982A (en) 1980-11-10
JPS5829952B2 JPS5829952B2 (en) 1983-06-25

Family

ID=15686984

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15913479A Expired JPS5829952B2 (en) 1979-12-10 1979-12-10 Thiophene derivative

Country Status (1)

Country Link
JP (1) JPS5829952B2 (en)

Also Published As

Publication number Publication date
JPS5829952B2 (en) 1983-06-25

Similar Documents

Publication Publication Date Title
JPS54148788A (en) 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation
JPS5559140A (en) 3,5-dihydroxypentanoic alkyl ester derivative, its preparation and remedy for hyperlipemia containing the same as the effective component
ES412859A1 (en) Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof
JPS54119494A (en) Preparation of cephalosporin compound
JPS55143982A (en) Thiophene derivative
GB1397647A (en) Thiophene derivatives
JPS55129287A (en) Imidazole-dicarboxylic acid derivative
JPS56108794A (en) Preparation of 7-amino-3-thiadiazolylthiomethyl-3-cephem- 4-carboxylic acid derivative
JPS57159777A (en) 4-hydroxycyclopentenone compound and its preparation
ES8602685A1 (en) Imidazole derivative and its preparation
JPS55139387A (en) Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids
JPS55151549A (en) Production of guanidinocaproic ester
JPS57123140A (en) Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component
JPS5511501A (en) Novel 7-methoxycephalosporin
JPS5549384A (en) Novel antibacterial compound
JPS57144287A (en) Cyclopentabenzofuran derivative
ES2019199A6 (en) Production of indane derivative and synthetic intermediate therefor
JPS55120591A (en) Phosphinoethylmalonic acid derivative, and preparation thereof
JPS57106684A (en) Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation
JPS552638A (en) Cyanopyrazinecarboxylic ester and its preparation
JPS57116048A (en) Novel quinoline derivative
JPS54128594A (en) 3,7-disubstituted-3-cephem-4-carboxylic acid derivative
JPS554346A (en) Preparation of cephapirin sodium
JPS54130594A (en) Novel cephalosporin derivative
JPS5398987A (en) Novel process for preparation of 7-amino-3-substitued thiomethylcephemcarboxylic acids