JPS57144287A - Cyclopentabenzofuran derivative - Google Patents
Cyclopentabenzofuran derivativeInfo
- Publication number
- JPS57144287A JPS57144287A JP2953881A JP2953881A JPS57144287A JP S57144287 A JPS57144287 A JP S57144287A JP 2953881 A JP2953881 A JP 2953881A JP 2953881 A JP2953881 A JP 2953881A JP S57144287 A JPS57144287 A JP S57144287A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reacted
- methyl
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound of formulaI[R1 is -CH2(CH2)2CH2OR2 (R2 is H or tetrahydropyranyl), -CH2CH2CH2COOR3 (R3 is H, methyl, etc.), etc.; Y is H, Br, Cl, etc.].
EXAMPLE: Methyl 5-[ 1, 2, 3a, 8b-cis-tetrahydro-7-bromo-1, 2-synepoxycyclopenta(b)benzofuranylmethyloxy]acetate.
USE: Useful as a synthetic raw material for 5,6,7-trinor-4,8-inter-m-phenylene-PGI2 having hypotensive action, and industrially obtainable in high yield.
PROCESS: A compound of formula II is reacted with N-bromosuccinimide (NBS) under cooling with ice to give a bromohydrin, which is then reacted with a base, e.g. NaOH, to afford an epoxide of formula III. The resultant epoxide of formula III is then subjected to the hydrogenolysis in the presence of 5% Pd-barium sulfate catalyst to give a compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2953881A JPS57144287A (en) | 1981-03-02 | 1981-03-02 | Cyclopentabenzofuran derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2953881A JPS57144287A (en) | 1981-03-02 | 1981-03-02 | Cyclopentabenzofuran derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57144287A true JPS57144287A (en) | 1982-09-06 |
JPS6152156B2 JPS6152156B2 (en) | 1986-11-12 |
Family
ID=12278883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2953881A Granted JPS57144287A (en) | 1981-03-02 | 1981-03-02 | Cyclopentabenzofuran derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57144287A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084581A (en) * | 1990-12-18 | 1992-01-28 | E. R. Squibb & Sons, Inc. | Process for preparing (3R-(3aα,4β,7ββ,7aα))-octahydro-4,7 epoxyisobenzofuranol from associated aldehydes |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2899890T3 (en) | 2014-06-30 | 2022-03-15 | Altor Bioscience Corp | IL-15-based molecules and methods of using the same |
KR102392142B1 (en) | 2016-10-21 | 2022-04-28 | 알토 바이오사이언스 코포레이션 | Mutimeric IL-15-Based Molecules |
-
1981
- 1981-03-02 JP JP2953881A patent/JPS57144287A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5084581A (en) * | 1990-12-18 | 1992-01-28 | E. R. Squibb & Sons, Inc. | Process for preparing (3R-(3aα,4β,7ββ,7aα))-octahydro-4,7 epoxyisobenzofuranol from associated aldehydes |
Also Published As
Publication number | Publication date |
---|---|
JPS6152156B2 (en) | 1986-11-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS57144287A (en) | Cyclopentabenzofuran derivative | |
JPS5716882A (en) | Production of benzo-heteroring derivative | |
JPS5436274A (en) | Preparation of propiophenone derivative | |
JPS56108743A (en) | 3-nitro-2-hydroxy-4-phenylbutyric acid derivative, its ester and preparation thereof | |
JPS55141471A (en) | Preparation of alpha-dimethylamino-epsilon-caprolactam | |
JPS5495533A (en) | Preparation of derivative of anthranylaldehyde | |
JPS5432484A (en) | Preparation of 5,8-dihydroxy-3,4-dihydro-carbostyril | |
JPS5419985A (en) | Production of hydroxycarbostyril derivative | |
JPS5217447A (en) | Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester | |
JPS5436226A (en) | Preparation of derivative of phenyl acetic acid | |
JPS51115460A (en) | Method for preparing 2-oxabicyclo-(3.3.0)-oct-b-ene-3-one | |
JPS5476555A (en) | Production of intermediate for prostaglandin analog | |
JPS5295648A (en) | Preparation of dihydrodicyclopentadiene | |
JPS5668668A (en) | Preparation of 2-indolinones | |
JPS5772963A (en) | Alpha-(2-pyridyl)arylacetaldehyde | |
JPS57135049A (en) | Method and catalyst for preparing hydroxyphenyl substituted fatty acid | |
JPS55111468A (en) | Preparation of n-benzyl-tetrahydro isoquinoline derivative | |
JPS5419979A (en) | Production of 4-methylisocoumarin derivative | |
JPS51138611A (en) | Process for preparation of delta- alkoxyl-alpha,beta-unsaturated aldehyde | |
JPS5448743A (en) | Preparation of benzoin ether | |
JPS57135048A (en) | Method and catalyst for preparing hydroxyphenyl substituted fatty acid | |
JPS5795980A (en) | 7-hydroxy pgi2 and its preparation | |
JPS51133249A (en) | A process for preparing alkyl-2,4- dichloro-nitrophenylcarbonates | |
JPS5384968A (en) | Production of 2,4-substituted-5-oxazolone | |
JPS5585568A (en) | Quinolinone-imine derivative and its preparation |