JPS57144287A - Cyclopentabenzofuran derivative - Google Patents

Cyclopentabenzofuran derivative

Info

Publication number
JPS57144287A
JPS57144287A JP2953881A JP2953881A JPS57144287A JP S57144287 A JPS57144287 A JP S57144287A JP 2953881 A JP2953881 A JP 2953881A JP 2953881 A JP2953881 A JP 2953881A JP S57144287 A JPS57144287 A JP S57144287A
Authority
JP
Japan
Prior art keywords
compound
formula
reacted
methyl
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2953881A
Other languages
Japanese (ja)
Other versions
JPS6152156B2 (en
Inventor
Kiyotaka Ono
Hiroshi Nagase
Mamoru Ishikawa
Kazuhisa Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP2953881A priority Critical patent/JPS57144287A/en
Publication of JPS57144287A publication Critical patent/JPS57144287A/en
Publication of JPS6152156B2 publication Critical patent/JPS6152156B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formulaI[R1 is -CH2(CH2)2CH2OR2 (R2 is H or tetrahydropyranyl), -CH2CH2CH2COOR3 (R3 is H, methyl, etc.), etc.; Y is H, Br, Cl, etc.].
EXAMPLE: Methyl 5-[ 1, 2, 3a, 8b-cis-tetrahydro-7-bromo-1, 2-synepoxycyclopenta(b)benzofuranylmethyloxy]acetate.
USE: Useful as a synthetic raw material for 5,6,7-trinor-4,8-inter-m-phenylene-PGI2 having hypotensive action, and industrially obtainable in high yield.
PROCESS: A compound of formula II is reacted with N-bromosuccinimide (NBS) under cooling with ice to give a bromohydrin, which is then reacted with a base, e.g. NaOH, to afford an epoxide of formula III. The resultant epoxide of formula III is then subjected to the hydrogenolysis in the presence of 5% Pd-barium sulfate catalyst to give a compound of formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP2953881A 1981-03-02 1981-03-02 Cyclopentabenzofuran derivative Granted JPS57144287A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2953881A JPS57144287A (en) 1981-03-02 1981-03-02 Cyclopentabenzofuran derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2953881A JPS57144287A (en) 1981-03-02 1981-03-02 Cyclopentabenzofuran derivative

Publications (2)

Publication Number Publication Date
JPS57144287A true JPS57144287A (en) 1982-09-06
JPS6152156B2 JPS6152156B2 (en) 1986-11-12

Family

ID=12278883

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2953881A Granted JPS57144287A (en) 1981-03-02 1981-03-02 Cyclopentabenzofuran derivative

Country Status (1)

Country Link
JP (1) JPS57144287A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084581A (en) * 1990-12-18 1992-01-28 E. R. Squibb & Sons, Inc. Process for preparing (3R-(3aα,4β,7ββ,7aα))-octahydro-4,7 epoxyisobenzofuranol from associated aldehydes

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2899890T3 (en) 2014-06-30 2022-03-15 Altor Bioscience Corp IL-15-based molecules and methods of using the same
KR102392142B1 (en) 2016-10-21 2022-04-28 알토 바이오사이언스 코포레이션 Mutimeric IL-15-Based Molecules

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084581A (en) * 1990-12-18 1992-01-28 E. R. Squibb & Sons, Inc. Process for preparing (3R-(3aα,4β,7ββ,7aα))-octahydro-4,7 epoxyisobenzofuranol from associated aldehydes

Also Published As

Publication number Publication date
JPS6152156B2 (en) 1986-11-12

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