JPS55139377A - Production of protoberberines - Google Patents

Production of protoberberines

Info

Publication number
JPS55139377A
JPS55139377A JP4429479A JP4429479A JPS55139377A JP S55139377 A JPS55139377 A JP S55139377A JP 4429479 A JP4429479 A JP 4429479A JP 4429479 A JP4429479 A JP 4429479A JP S55139377 A JPS55139377 A JP S55139377A
Authority
JP
Japan
Prior art keywords
formula
oxide
ring closure
tetrahydroisoquinoline
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4429479A
Other languages
Japanese (ja)
Inventor
Tetsuji Kametani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENDAI FUKUSOKAN KAGAKU KENKYU
SENDAI FUKUSOKAN KAGAKU KENKYUSHO
Original Assignee
SENDAI FUKUSOKAN KAGAKU KENKYU
SENDAI FUKUSOKAN KAGAKU KENKYUSHO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENDAI FUKUSOKAN KAGAKU KENKYU, SENDAI FUKUSOKAN KAGAKU KENKYUSHO filed Critical SENDAI FUKUSOKAN KAGAKU KENKYU
Priority to JP4429479A priority Critical patent/JPS55139377A/en
Publication of JPS55139377A publication Critical patent/JPS55139377A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: The ring closure reaction of a specific tetrahydroisoquinoline N-oxide readily gives a protoberberin useful as medicine.
CONSTITUTION: The ring closure reaction of a tetrahydroisoquinoline N-oxide of formula I (R is lower alkyl; R1, R2 are hydroxyl, lower alkoxy) is conducted in a solvent such as methanol, propanol or acetic acid at 0W100°C, preferably in the presence of a catalyst such as ferrous sulfate to produce a protoberberine of formula II (R3 is H, hydroxyl, lower alkoxy). For example, the ring closure of reticulin N- oxide of formula III can produce coreximine of formula IV and scoulerin of formula V.
COPYRIGHT: (C)1980,JPO&Japio
JP4429479A 1979-04-13 1979-04-13 Production of protoberberines Pending JPS55139377A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4429479A JPS55139377A (en) 1979-04-13 1979-04-13 Production of protoberberines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4429479A JPS55139377A (en) 1979-04-13 1979-04-13 Production of protoberberines

Publications (1)

Publication Number Publication Date
JPS55139377A true JPS55139377A (en) 1980-10-31

Family

ID=12687481

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4429479A Pending JPS55139377A (en) 1979-04-13 1979-04-13 Production of protoberberines

Country Status (1)

Country Link
JP (1) JPS55139377A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014515379A (en) * 2011-05-27 2014-06-30 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ Hexahydrodibenzo [a, g] quinolizine compound, process for producing the same, pharmaceutical composition and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014515379A (en) * 2011-05-27 2014-06-30 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ Hexahydrodibenzo [a, g] quinolizine compound, process for producing the same, pharmaceutical composition and application thereof
JP2017019768A (en) * 2011-05-27 2017-01-26 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズＳｈａｎｇｈａｉ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｍａｔｅｒｉａ Ｍｅｄｉｃａ， Ｃｈｉｎｅｓｅ Ａｃａｄｅｍｙ Ｏｆ Ｓｃｉｅｎｃｅｓ Hexahydrodibenzo[a,g]quinolizine compound, manufacturing method therefor, pharmaceutical composition and application thereof

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