JPS55133343A - Thiopronine derivative - Google Patents
Thiopronine derivativeInfo
- Publication number
- JPS55133343A JPS55133343A JP4131979A JP4131979A JPS55133343A JP S55133343 A JPS55133343 A JP S55133343A JP 4131979 A JP4131979 A JP 4131979A JP 4131979 A JP4131979 A JP 4131979A JP S55133343 A JPS55133343 A JP S55133343A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- thiopronine
- derivative
- thiopromine
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical class CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 title abstract 3
- -1 amino, phenyl Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 208000002177 Cataract Diseases 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 abstract 1
- 108010024636 Glutathione Proteins 0.000 abstract 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 abstract 1
- 108010058907 Tiopronin Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003356 anti-rheumatic effect Effects 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229960003180 glutathione Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 abstract 1
- 229960003495 thiamine Drugs 0.000 abstract 1
- 235000019157 thiamine Nutrition 0.000 abstract 1
- 239000011721 thiamine Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 229960004402 tiopronin Drugs 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4131979A JPS55133343A (en) | 1979-04-04 | 1979-04-04 | Thiopronine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4131979A JPS55133343A (en) | 1979-04-04 | 1979-04-04 | Thiopronine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55133343A true JPS55133343A (en) | 1980-10-17 |
| JPS6257619B2 JPS6257619B2 (enrdf_load_stackoverflow) | 1987-12-02 |
Family
ID=12605186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4131979A Granted JPS55133343A (en) | 1979-04-04 | 1979-04-04 | Thiopronine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55133343A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305845C (zh) * | 2005-05-16 | 2007-03-21 | 河南省新谊药业股份有限公司 | 用于治疗急慢性肝病的无水硫普罗宁钠及其制备方法 |
| CN100383521C (zh) * | 2005-09-23 | 2008-04-23 | 复旦大学 | 一种测定硫普罗宁浓度的方法 |
| JP2016510729A (ja) * | 2013-02-28 | 2016-04-11 | タフツ ユニバーシティー | 薬剤のデリバリーのためのジスルフィド化合物 |
-
1979
- 1979-04-04 JP JP4131979A patent/JPS55133343A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305845C (zh) * | 2005-05-16 | 2007-03-21 | 河南省新谊药业股份有限公司 | 用于治疗急慢性肝病的无水硫普罗宁钠及其制备方法 |
| CN100383521C (zh) * | 2005-09-23 | 2008-04-23 | 复旦大学 | 一种测定硫普罗宁浓度的方法 |
| JP2016510729A (ja) * | 2013-02-28 | 2016-04-11 | タフツ ユニバーシティー | 薬剤のデリバリーのためのジスルフィド化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6257619B2 (enrdf_load_stackoverflow) | 1987-12-02 |
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