JPS5513246A - Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine - Google Patents

Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine

Info

Publication number
JPS5513246A
JPS5513246A JP8639378A JP8639378A JPS5513246A JP S5513246 A JPS5513246 A JP S5513246A JP 8639378 A JP8639378 A JP 8639378A JP 8639378 A JP8639378 A JP 8639378A JP S5513246 A JPS5513246 A JP S5513246A
Authority
JP
Japan
Prior art keywords
compound
formula
ethyl
sulfamoylbenzamidomethyl
hipher
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8639378A
Other languages
Japanese (ja)
Inventor
Kazumasa Oba
Toshio Horisaki
Tsutomu Adachi
Isao Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Teikoku Chemical Industry Co Ltd
Original Assignee
Teikoku Chemical Industry Co Ltd
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Chemical Industry Co Ltd, Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Chemical Industry Co Ltd
Priority to JP8639378A priority Critical patent/JPS5513246A/en
Publication of JPS5513246A publication Critical patent/JPS5513246A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound useful as medicines in a simple process, by dealkoxycarbonylating the condensate of a pyrrolidinone derivative with a hippuric acid derivative treated with an acid, and by reducing the reaction product via a novel intermediate.
CONSTITUTION: A compound of formula IV: (R is lower alkyl group) is reacted with an alkali metal and then an alkylated N-ethyl-2-pyrrolidinone to form a compound of formula III, which is treated with hydrochloric acid to give a compound of formula II. The resulting compound is reduced in the presence of a catalyst, e.g. palladium carbon or Raney nickel, to form a compound of formula I. The reactions are preferably carried out in a solvent, e.g. methanol.
COPYRIGHT: (C)1980,JPO&Japio
JP8639378A 1978-07-14 1978-07-14 Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine Pending JPS5513246A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8639378A JPS5513246A (en) 1978-07-14 1978-07-14 Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8639378A JPS5513246A (en) 1978-07-14 1978-07-14 Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine

Publications (1)

Publication Number Publication Date
JPS5513246A true JPS5513246A (en) 1980-01-30

Family

ID=13885623

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8639378A Pending JPS5513246A (en) 1978-07-14 1978-07-14 Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine

Country Status (1)

Country Link
JP (1) JPS5513246A (en)

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