JPS5513246A - Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine - Google Patents
Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidineInfo
- Publication number
- JPS5513246A JPS5513246A JP8639378A JP8639378A JPS5513246A JP S5513246 A JPS5513246 A JP S5513246A JP 8639378 A JP8639378 A JP 8639378A JP 8639378 A JP8639378 A JP 8639378A JP S5513246 A JPS5513246 A JP S5513246A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- ethyl
- sulfamoylbenzamidomethyl
- hipher
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound useful as medicines in a simple process, by dealkoxycarbonylating the condensate of a pyrrolidinone derivative with a hippuric acid derivative treated with an acid, and by reducing the reaction product via a novel intermediate.
CONSTITUTION: A compound of formula IV: (R is lower alkyl group) is reacted with an alkali metal and then an alkylated N-ethyl-2-pyrrolidinone to form a compound of formula III, which is treated with hydrochloric acid to give a compound of formula II. The resulting compound is reduced in the presence of a catalyst, e.g. palladium carbon or Raney nickel, to form a compound of formula I. The reactions are preferably carried out in a solvent, e.g. methanol.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8639378A JPS5513246A (en) | 1978-07-14 | 1978-07-14 | Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8639378A JPS5513246A (en) | 1978-07-14 | 1978-07-14 | Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5513246A true JPS5513246A (en) | 1980-01-30 |
Family
ID=13885623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8639378A Pending JPS5513246A (en) | 1978-07-14 | 1978-07-14 | Preparation of n-ethyl-2-(2-methoxy-5- sulfamoylbenzamidomethyl)-(hipher)pyrrolidine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5513246A (en) |
-
1978
- 1978-07-14 JP JP8639378A patent/JPS5513246A/en active Pending
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