JPS55130957A - Production of benzamide derivative - Google Patents

Production of benzamide derivative

Info

Publication number
JPS55130957A
JPS55130957A JP3707179A JP3707179A JPS55130957A JP S55130957 A JPS55130957 A JP S55130957A JP 3707179 A JP3707179 A JP 3707179A JP 3707179 A JP3707179 A JP 3707179A JP S55130957 A JPS55130957 A JP S55130957A
Authority
JP
Japan
Prior art keywords
formula
derivative
alkoxy
halogen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3707179A
Other languages
Japanese (ja)
Inventor
Nobunori Takemoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP3707179A priority Critical patent/JPS55130957A/en
Publication of JPS55130957A publication Critical patent/JPS55130957A/en
Pending legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: Readily available starting materials, benzaldehyde derivative and amine derivative are made to react under mild conditions to give title compound having central nervous system depressing and antiulcerative activities.
CONSTITUTION: The reaction between a benzaldehyde derivative of formula I (R1, R2 are H, halogen, alkoxy, alkanoylamino, sulfamoyl, nitro; R3 is H, alkoxy, halogen) and an amine derivative of formula II (R4 is H, alkyl, allyl, aryl; R5 is H, alkyl, benzyl; m is 1W3; n is 0W3) is carried out in the presence of a cyanide compound of the formula: MCN (M is H, alkali metal, ammonium ion) and an oxidant of manganese dioxide or chromium monoxide or the like, preferably in a solvent such as isopropyl alcohol at a temperature of 20°C to the boiling point of the solvent to give the objective compound such as 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidemethyl) pyrrolidine of formula III.
COPYRIGHT: (C)1980,JPO&Japio
JP3707179A 1979-03-30 1979-03-30 Production of benzamide derivative Pending JPS55130957A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3707179A JPS55130957A (en) 1979-03-30 1979-03-30 Production of benzamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3707179A JPS55130957A (en) 1979-03-30 1979-03-30 Production of benzamide derivative

Publications (1)

Publication Number Publication Date
JPS55130957A true JPS55130957A (en) 1980-10-11

Family

ID=12487310

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3707179A Pending JPS55130957A (en) 1979-03-30 1979-03-30 Production of benzamide derivative

Country Status (1)

Country Link
JP (1) JPS55130957A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178859A (en) * 1984-01-31 1985-09-12 アストラ・レーケメデル・アクチエボラーグ Oxysalicylamide derivative
US4550179A (en) * 1980-08-28 1985-10-29 Societe D'etudes Scientifiques Et Industrielles De L'ile-De France N-(1-Allyl-2-pyrrolidinyl-methyl) 2-methoxy-4-amino-5-methylsulfamoyl benzamide
US4822792A (en) * 1986-12-23 1989-04-18 Riom Laboratoires C.E.R.M. Substituted 3-piperidinamines or 3-azepinamines, the preparation thereof and their applications in therapy
US5154913A (en) * 1987-11-19 1992-10-13 Vanderbilt University Radioiodinated benzamines method of their use as radioimaging agents

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550179A (en) * 1980-08-28 1985-10-29 Societe D'etudes Scientifiques Et Industrielles De L'ile-De France N-(1-Allyl-2-pyrrolidinyl-methyl) 2-methoxy-4-amino-5-methylsulfamoyl benzamide
JPS60178859A (en) * 1984-01-31 1985-09-12 アストラ・レーケメデル・アクチエボラーグ Oxysalicylamide derivative
US4822792A (en) * 1986-12-23 1989-04-18 Riom Laboratoires C.E.R.M. Substituted 3-piperidinamines or 3-azepinamines, the preparation thereof and their applications in therapy
US5154913A (en) * 1987-11-19 1992-10-13 Vanderbilt University Radioiodinated benzamines method of their use as radioimaging agents

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