JPS55130957A - Production of benzamide derivative - Google Patents
Production of benzamide derivativeInfo
- Publication number
- JPS55130957A JPS55130957A JP3707179A JP3707179A JPS55130957A JP S55130957 A JPS55130957 A JP S55130957A JP 3707179 A JP3707179 A JP 3707179A JP 3707179 A JP3707179 A JP 3707179A JP S55130957 A JPS55130957 A JP S55130957A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- alkoxy
- halogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
PURPOSE: Readily available starting materials, benzaldehyde derivative and amine derivative are made to react under mild conditions to give title compound having central nervous system depressing and antiulcerative activities.
CONSTITUTION: The reaction between a benzaldehyde derivative of formula I (R1, R2 are H, halogen, alkoxy, alkanoylamino, sulfamoyl, nitro; R3 is H, alkoxy, halogen) and an amine derivative of formula II (R4 is H, alkyl, allyl, aryl; R5 is H, alkyl, benzyl; m is 1W3; n is 0W3) is carried out in the presence of a cyanide compound of the formula: MCN (M is H, alkali metal, ammonium ion) and an oxidant of manganese dioxide or chromium monoxide or the like, preferably in a solvent such as isopropyl alcohol at a temperature of 20°C to the boiling point of the solvent to give the objective compound such as 1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidemethyl) pyrrolidine of formula III.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3707179A JPS55130957A (en) | 1979-03-30 | 1979-03-30 | Production of benzamide derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3707179A JPS55130957A (en) | 1979-03-30 | 1979-03-30 | Production of benzamide derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55130957A true JPS55130957A (en) | 1980-10-11 |
Family
ID=12487310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3707179A Pending JPS55130957A (en) | 1979-03-30 | 1979-03-30 | Production of benzamide derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55130957A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60178859A (en) * | 1984-01-31 | 1985-09-12 | アストラ・レーケメデル・アクチエボラーグ | Oxysalicylamide derivative |
US4550179A (en) * | 1980-08-28 | 1985-10-29 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De France | N-(1-Allyl-2-pyrrolidinyl-methyl) 2-methoxy-4-amino-5-methylsulfamoyl benzamide |
US4822792A (en) * | 1986-12-23 | 1989-04-18 | Riom Laboratoires C.E.R.M. | Substituted 3-piperidinamines or 3-azepinamines, the preparation thereof and their applications in therapy |
US5154913A (en) * | 1987-11-19 | 1992-10-13 | Vanderbilt University | Radioiodinated benzamines method of their use as radioimaging agents |
-
1979
- 1979-03-30 JP JP3707179A patent/JPS55130957A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4550179A (en) * | 1980-08-28 | 1985-10-29 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De France | N-(1-Allyl-2-pyrrolidinyl-methyl) 2-methoxy-4-amino-5-methylsulfamoyl benzamide |
JPS60178859A (en) * | 1984-01-31 | 1985-09-12 | アストラ・レーケメデル・アクチエボラーグ | Oxysalicylamide derivative |
US4822792A (en) * | 1986-12-23 | 1989-04-18 | Riom Laboratoires C.E.R.M. | Substituted 3-piperidinamines or 3-azepinamines, the preparation thereof and their applications in therapy |
US5154913A (en) * | 1987-11-19 | 1992-10-13 | Vanderbilt University | Radioiodinated benzamines method of their use as radioimaging agents |
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