JPS55129224A - Fine granules having improved taste - Google Patents
Fine granules having improved tasteInfo
- Publication number
- JPS55129224A JPS55129224A JP3667279A JP3667279A JPS55129224A JP S55129224 A JPS55129224 A JP S55129224A JP 3667279 A JP3667279 A JP 3667279A JP 3667279 A JP3667279 A JP 3667279A JP S55129224 A JPS55129224 A JP S55129224A
- Authority
- JP
- Japan
- Prior art keywords
- medicine
- bitter taste
- dissolution
- surface area
- granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To prepare the title composition having high rate of dissolution, by granulating a medicine and coating with an antiacid agent and ethylcellulose.
CONSTITUTION: A medicine which forms an insoluble or hardly soluble free base in an acidic aqueous solution, and exhibits bitter taste, e.g. dicloxacillin sodium salt, is granulated e.g. by fluid bed granulation process, to obtain granules having high specific surface area. The surface of the granules is coated with ethylecellulose containing an antiacid agent (e.g. magnesium metasilicate aluminate) to mask the bitter taste of the medicine. Since the composition thus prepared has high specific volume and specific surface area, it has high rate of dissolution in spite of the masking of the bitter taste.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3667279A JPS55129224A (en) | 1979-03-27 | 1979-03-27 | Fine granules having improved taste |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3667279A JPS55129224A (en) | 1979-03-27 | 1979-03-27 | Fine granules having improved taste |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55129224A true JPS55129224A (en) | 1980-10-06 |
Family
ID=12476339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3667279A Pending JPS55129224A (en) | 1979-03-27 | 1979-03-27 | Fine granules having improved taste |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55129224A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0069097A2 (en) * | 1981-06-18 | 1983-01-05 | Astra Läkemedel Aktiebolag | Pharmaceutical mixture |
US4581232A (en) * | 1983-07-20 | 1986-04-08 | Warner-Lambert Company | Magnesium trisilicate suitable for preparation of medicament adsorbates |
JPS62123118A (en) * | 1985-09-30 | 1987-06-04 | グラクソ・グル−プ・リミテツド | Medicinal composition |
JPH037220A (en) * | 1989-03-30 | 1991-01-14 | Yoshitomi Pharmaceut Ind Ltd | Stable tablet containing alkylcysteine or acid addition salt thereof |
JP2004161701A (en) * | 2002-11-14 | 2004-06-10 | Kobayashi Pharmaceut Co Ltd | Composition in which bitterness and odor of cysteines are reduced |
WO2011040195A1 (en) * | 2009-09-30 | 2011-04-07 | ライオン株式会社 | Unpleasant taste-masking particles and an oral preparation containing same |
JP2013209332A (en) * | 2012-03-30 | 2013-10-10 | Kobayashi Pharmaceutical Co Ltd | Method for producing solid preparation having reduced unpleasant taste |
US8945618B2 (en) | 1996-06-14 | 2015-02-03 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US9040086B2 (en) | 2001-10-04 | 2015-05-26 | Aptalis Pharmatech, Inc. | Timed, sustained release systems for propranolol |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9233105B2 (en) | 2009-12-02 | 2016-01-12 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US10130580B2 (en) | 2004-10-12 | 2018-11-20 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US10471017B2 (en) | 2004-10-21 | 2019-11-12 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS48103718A (en) * | 1972-04-14 | 1973-12-26 |
-
1979
- 1979-03-27 JP JP3667279A patent/JPS55129224A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS48103718A (en) * | 1972-04-14 | 1973-12-26 |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4656027A (en) * | 1981-06-18 | 1987-04-07 | Astra Lakemedel Aktiebolag | Pharmaceutical mixture |
EP0069097A2 (en) * | 1981-06-18 | 1983-01-05 | Astra Läkemedel Aktiebolag | Pharmaceutical mixture |
US4581232A (en) * | 1983-07-20 | 1986-04-08 | Warner-Lambert Company | Magnesium trisilicate suitable for preparation of medicament adsorbates |
JPS62123118A (en) * | 1985-09-30 | 1987-06-04 | グラクソ・グル−プ・リミテツド | Medicinal composition |
JPH037220A (en) * | 1989-03-30 | 1991-01-14 | Yoshitomi Pharmaceut Ind Ltd | Stable tablet containing alkylcysteine or acid addition salt thereof |
US8945618B2 (en) | 1996-06-14 | 2015-02-03 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US8956650B2 (en) | 1996-06-14 | 2015-02-17 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
US9040086B2 (en) | 2001-10-04 | 2015-05-26 | Aptalis Pharmatech, Inc. | Timed, sustained release systems for propranolol |
JP2004161701A (en) * | 2002-11-14 | 2004-06-10 | Kobayashi Pharmaceut Co Ltd | Composition in which bitterness and odor of cysteines are reduced |
JP4501024B2 (en) * | 2002-11-14 | 2010-07-14 | 小林製薬株式会社 | Composition with reduced bitterness and odor of cysteines |
US10130580B2 (en) | 2004-10-12 | 2018-11-20 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US11452689B2 (en) | 2004-10-12 | 2022-09-27 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US10568832B2 (en) | 2004-10-12 | 2020-02-25 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
US10471017B2 (en) | 2004-10-21 | 2019-11-12 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US10952971B2 (en) | 2004-10-21 | 2021-03-23 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
US10500161B2 (en) | 2005-05-02 | 2019-12-10 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9566249B2 (en) | 2005-05-02 | 2017-02-14 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9579293B2 (en) | 2005-05-02 | 2017-02-28 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US10045946B2 (en) | 2005-05-02 | 2018-08-14 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US11147772B2 (en) | 2005-05-02 | 2021-10-19 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9161919B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
WO2011040195A1 (en) * | 2009-09-30 | 2011-04-07 | ライオン株式会社 | Unpleasant taste-masking particles and an oral preparation containing same |
JP2011093882A (en) * | 2009-09-30 | 2011-05-12 | Lion Corp | Unpleasant taste-masking particle and oral preparation containing the same |
US10166220B2 (en) | 2009-12-02 | 2019-01-01 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US10729682B2 (en) | 2009-12-02 | 2020-08-04 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US9233105B2 (en) | 2009-12-02 | 2016-01-12 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
JP2013209332A (en) * | 2012-03-30 | 2013-10-10 | Kobayashi Pharmaceutical Co Ltd | Method for producing solid preparation having reduced unpleasant taste |
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