JPS55129224A - Fine granules having improved taste - Google Patents

Fine granules having improved taste

Info

Publication number
JPS55129224A
JPS55129224A JP3667279A JP3667279A JPS55129224A JP S55129224 A JPS55129224 A JP S55129224A JP 3667279 A JP3667279 A JP 3667279A JP 3667279 A JP3667279 A JP 3667279A JP S55129224 A JPS55129224 A JP S55129224A
Authority
JP
Japan
Prior art keywords
medicine
bitter taste
dissolution
surface area
granules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3667279A
Other languages
Japanese (ja)
Inventor
Masaki Hasegawa
Mitsuru Fukushima
Renji Aikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP3667279A priority Critical patent/JPS55129224A/en
Publication of JPS55129224A publication Critical patent/JPS55129224A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To prepare the title composition having high rate of dissolution, by granulating a medicine and coating with an antiacid agent and ethylcellulose.
CONSTITUTION: A medicine which forms an insoluble or hardly soluble free base in an acidic aqueous solution, and exhibits bitter taste, e.g. dicloxacillin sodium salt, is granulated e.g. by fluid bed granulation process, to obtain granules having high specific surface area. The surface of the granules is coated with ethylecellulose containing an antiacid agent (e.g. magnesium metasilicate aluminate) to mask the bitter taste of the medicine. Since the composition thus prepared has high specific volume and specific surface area, it has high rate of dissolution in spite of the masking of the bitter taste.
COPYRIGHT: (C)1980,JPO&Japio
JP3667279A 1979-03-27 1979-03-27 Fine granules having improved taste Pending JPS55129224A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3667279A JPS55129224A (en) 1979-03-27 1979-03-27 Fine granules having improved taste

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3667279A JPS55129224A (en) 1979-03-27 1979-03-27 Fine granules having improved taste

Publications (1)

Publication Number Publication Date
JPS55129224A true JPS55129224A (en) 1980-10-06

Family

ID=12476339

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3667279A Pending JPS55129224A (en) 1979-03-27 1979-03-27 Fine granules having improved taste

Country Status (1)

Country Link
JP (1) JPS55129224A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069097A2 (en) * 1981-06-18 1983-01-05 Astra Läkemedel Aktiebolag Pharmaceutical mixture
US4581232A (en) * 1983-07-20 1986-04-08 Warner-Lambert Company Magnesium trisilicate suitable for preparation of medicament adsorbates
JPS62123118A (en) * 1985-09-30 1987-06-04 グラクソ・グル−プ・リミテツド Medicinal composition
JPH037220A (en) * 1989-03-30 1991-01-14 Yoshitomi Pharmaceut Ind Ltd Stable tablet containing alkylcysteine or acid addition salt thereof
JP2004161701A (en) * 2002-11-14 2004-06-10 Kobayashi Pharmaceut Co Ltd Composition in which bitterness and odor of cysteines are reduced
WO2011040195A1 (en) * 2009-09-30 2011-04-07 ライオン株式会社 Unpleasant taste-masking particles and an oral preparation containing same
JP2013209332A (en) * 2012-03-30 2013-10-10 Kobayashi Pharmaceutical Co Ltd Method for producing solid preparation having reduced unpleasant taste
US8945618B2 (en) 1996-06-14 2015-02-03 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US9040086B2 (en) 2001-10-04 2015-05-26 Aptalis Pharmatech, Inc. Timed, sustained release systems for propranolol
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US9233105B2 (en) 2009-12-02 2016-01-12 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
US10130580B2 (en) 2004-10-12 2018-11-20 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
US10471017B2 (en) 2004-10-21 2019-11-12 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS48103718A (en) * 1972-04-14 1973-12-26

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS48103718A (en) * 1972-04-14 1973-12-26

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656027A (en) * 1981-06-18 1987-04-07 Astra Lakemedel Aktiebolag Pharmaceutical mixture
EP0069097A2 (en) * 1981-06-18 1983-01-05 Astra Läkemedel Aktiebolag Pharmaceutical mixture
US4581232A (en) * 1983-07-20 1986-04-08 Warner-Lambert Company Magnesium trisilicate suitable for preparation of medicament adsorbates
JPS62123118A (en) * 1985-09-30 1987-06-04 グラクソ・グル−プ・リミテツド Medicinal composition
JPH037220A (en) * 1989-03-30 1991-01-14 Yoshitomi Pharmaceut Ind Ltd Stable tablet containing alkylcysteine or acid addition salt thereof
US8945618B2 (en) 1996-06-14 2015-02-03 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US8956650B2 (en) 1996-06-14 2015-02-17 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US9040086B2 (en) 2001-10-04 2015-05-26 Aptalis Pharmatech, Inc. Timed, sustained release systems for propranolol
JP2004161701A (en) * 2002-11-14 2004-06-10 Kobayashi Pharmaceut Co Ltd Composition in which bitterness and odor of cysteines are reduced
JP4501024B2 (en) * 2002-11-14 2010-07-14 小林製薬株式会社 Composition with reduced bitterness and odor of cysteines
US10130580B2 (en) 2004-10-12 2018-11-20 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
US11452689B2 (en) 2004-10-12 2022-09-27 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
US10568832B2 (en) 2004-10-12 2020-02-25 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
US10471017B2 (en) 2004-10-21 2019-11-12 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US10952971B2 (en) 2004-10-21 2021-03-23 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US10500161B2 (en) 2005-05-02 2019-12-10 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US9566249B2 (en) 2005-05-02 2017-02-14 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US9579293B2 (en) 2005-05-02 2017-02-28 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US10045946B2 (en) 2005-05-02 2018-08-14 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US11147772B2 (en) 2005-05-02 2021-10-19 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US9161919B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
WO2011040195A1 (en) * 2009-09-30 2011-04-07 ライオン株式会社 Unpleasant taste-masking particles and an oral preparation containing same
JP2011093882A (en) * 2009-09-30 2011-05-12 Lion Corp Unpleasant taste-masking particle and oral preparation containing the same
US10166220B2 (en) 2009-12-02 2019-01-01 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
US10729682B2 (en) 2009-12-02 2020-08-04 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
US9233105B2 (en) 2009-12-02 2016-01-12 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
JP2013209332A (en) * 2012-03-30 2013-10-10 Kobayashi Pharmaceutical Co Ltd Method for producing solid preparation having reduced unpleasant taste

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