JPS5511505A

JPS5511505A - Novel 9,3"-acylleucomycin and its preparation

Novel 9,3"-acylleucomycin and its preparation

Info

Publication number: JPS5511505A
Authority: JP; Japan
Prior art keywords: compound; alkanoyl; formula; antibiotic; iii
Prior art date: 1978-06-07
Legal status : Granted

Application number

JP6913678A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6313999B2 (enrdf_load_stackoverflow

Inventor

Hideo Sakakibara

Osamu Okegawa

Toshiyuki Watanabe

Tatsuro Fujiwara

Susumu Watanabe

Satoshi Omura

Tetsuo Matsuda

Current Assignee

Toyo Jozo KK

Original Assignee

Toyo Jozo KK

Priority date

1978-06-07

Filing date

1978-06-07

Publication date

1980-01-26

1978-06-07 Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK

1978-06-07 Priority to JP6913678A priority Critical patent/JPS5511505A/ja

1980-01-26 Publication of JPS5511505A publication Critical patent/JPS5511505A/ja

1988-03-29 Publication of JPS6313999B2 publication Critical patent/JPS6313999B2/ja

Status Granted legal-status Critical Current

Links

OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
125000001589 carboacyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
230000003115 biocidal effect Effects 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
208000035473 Communicable disease Diseases 0.000 abstract 1
101100476962 Drosophila melanogaster Sirup gene Proteins 0.000 abstract 1
IEMDOFXTVAPVLX-YWQHLDGFSA-N Leucomycin A1 Chemical compound CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](OC(=O)CC(C)C)[C@](C)(O)C2)[C@@H](C)O1 IEMDOFXTVAPVLX-YWQHLDGFSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
235000019658 bitter taste Nutrition 0.000 abstract 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
150000004820 halides Chemical class 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
235000020357 syrup Nutrition 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1