JPS5490178A - 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation - Google Patents

6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation

Info

Publication number
JPS5490178A
JPS5490178A JP15658377A JP15658377A JPS5490178A JP S5490178 A JPS5490178 A JP S5490178A JP 15658377 A JP15658377 A JP 15658377A JP 15658377 A JP15658377 A JP 15658377A JP S5490178 A JPS5490178 A JP S5490178A
Authority
JP
Japan
Prior art keywords
formula
compound
give
ethylenedioxyethyl
fulvene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15658377A
Other languages
Japanese (ja)
Inventor
Tamotsu Fujisawa
Takeo Kobori
Kunikazu Sakai
Hiroko Shirogata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP15658377A priority Critical patent/JPS5490178A/en
Publication of JPS5490178A publication Critical patent/JPS5490178A/en
Pending legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An 6-(2,2-ethylenedioxyethyl)fulvene derivative of formula I: [R is (un)substituted alkyl group].
EXAMPLE: 6-(2,2-Ethylenedioxyheptyl) fulvene.
USE: A raw material for preparing precursors of prostaglandins widely used as hypotensive agents, diuretics, antithrombotic drugs, bronchodilators, etc. The compound is subjected to the Diels-Alder reaction to give precursors for brostaglandins.
PROCESS: The ketone site of a β-keto ester of formula II: (R1 is alkyl or aryl group) is protectd by ethylene glycol to form a compound of formula III, which is reduced by a reducing agent to give a compound of formula V. The resulting compound of formula IV is then oxidized to form a compound of formula IV, which is dehydrated and condensed with cyclopentadiene in the presence of an anion exchange resin to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP15658377A 1977-12-27 1977-12-27 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation Pending JPS5490178A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15658377A JPS5490178A (en) 1977-12-27 1977-12-27 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15658377A JPS5490178A (en) 1977-12-27 1977-12-27 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5490178A true JPS5490178A (en) 1979-07-17

Family

ID=15630926

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15658377A Pending JPS5490178A (en) 1977-12-27 1977-12-27 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5490178A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008137740A1 (en) * 2007-05-03 2008-11-13 Emory University Fulvene and fulvalene analogs and their use in treating cancers

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008137740A1 (en) * 2007-05-03 2008-11-13 Emory University Fulvene and fulvalene analogs and their use in treating cancers

Similar Documents

Publication Publication Date Title
JPS5576829A (en) Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it
JPS5490178A (en) 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation
JPS57159777A (en) 4-hydroxycyclopentenone compound and its preparation
JPS5289695A (en) Novel 7alpha-methoxycephalosporins and preparation thereof
JPS5699480A (en) Preparation of pyridopyrimidine derivative
JPS55100383A (en) Preparation of novel nitrogen-containing polycyclic compound
JPS5618935A (en) Novel bicyclo-octane derivative and its preparation
JPS5490177A (en) 3,3-ethylene-dioxypropanal derivative and its preparation
JPS54119445A (en) Preparation of 7-(3-oxo-1-alkenyl) bicyclo 2.2.1 hept-5- ene-2-one
JPS52107098A (en) Preparation of nitrogen-containing polymers
JPS5576871A (en) Chromanyloxy fatty acid homolog
JPS55108898A (en) 25-hydroxy-24-oxocholesterol derivative and its preparation
JPS5492947A (en) Production of bicyclo10.3.0pentadeca-1(12)-ene-13-one
JPS5557535A (en) Preparation of delta-ketocarboxylic acid
JPS5436274A (en) Preparation of propiophenone derivative
JPS5488248A (en) 7-(3-oxo-1-alkenyl)-bicyclo2.2.1hepta-5-ene-2-one and its preparation
JPS57131792A (en) Novel 2-oxabicyclo(2.2.2)octan-3-one derivative
JPS55115868A (en) Beta,beta,beta-trihalo-alpha-hydroxyethyl substituted-2-aroyl pyrrole derivative
JPS5515407A (en) 2-phenyl substituted 1-phthalazone derivative
JPS5531087A (en) Preparation of 5-acetyl-1,2,6-trimethyl-tricyclo 5.3.2.02,7 dodec-5-ene
JPS5239620A (en) Process for preparation of monocarboxylic ester having ethylenic doubl e bond
JPS5519230A (en) Endo-7-hydroxy-2,4-bishomobrendane
JPS5718683A (en) 3,8-epoxy-7-keto-6-oxabicyclo 3,2,1 octane derivative and its preparation
JPS5653685A (en) Production of cephalosporin derivative
JPS51138611A (en) Process for preparation of delta- alkoxyl-alpha,beta-unsaturated aldehyde