JPS5490178A - 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation - Google Patents
6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparationInfo
- Publication number
- JPS5490178A JPS5490178A JP15658377A JP15658377A JPS5490178A JP S5490178 A JPS5490178 A JP S5490178A JP 15658377 A JP15658377 A JP 15658377A JP 15658377 A JP15658377 A JP 15658377A JP S5490178 A JPS5490178 A JP S5490178A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- give
- ethylenedioxyethyl
- fulvene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An 6-(2,2-ethylenedioxyethyl)fulvene derivative of formula I: [R is (un)substituted alkyl group].
EXAMPLE: 6-(2,2-Ethylenedioxyheptyl) fulvene.
USE: A raw material for preparing precursors of prostaglandins widely used as hypotensive agents, diuretics, antithrombotic drugs, bronchodilators, etc. The compound is subjected to the Diels-Alder reaction to give precursors for brostaglandins.
PROCESS: The ketone site of a β-keto ester of formula II: (R1 is alkyl or aryl group) is protectd by ethylene glycol to form a compound of formula III, which is reduced by a reducing agent to give a compound of formula V. The resulting compound of formula IV is then oxidized to form a compound of formula IV, which is dehydrated and condensed with cyclopentadiene in the presence of an anion exchange resin to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15658377A JPS5490178A (en) | 1977-12-27 | 1977-12-27 | 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15658377A JPS5490178A (en) | 1977-12-27 | 1977-12-27 | 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5490178A true JPS5490178A (en) | 1979-07-17 |
Family
ID=15630926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15658377A Pending JPS5490178A (en) | 1977-12-27 | 1977-12-27 | 6-(2,2-ethylenedioxyethyl)-fulvene derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5490178A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008137740A1 (en) * | 2007-05-03 | 2008-11-13 | Emory University | Fulvene and fulvalene analogs and their use in treating cancers |
-
1977
- 1977-12-27 JP JP15658377A patent/JPS5490178A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008137740A1 (en) * | 2007-05-03 | 2008-11-13 | Emory University | Fulvene and fulvalene analogs and their use in treating cancers |
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