JPS5441387A - Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin - Google Patents
Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycinInfo
- Publication number
- JPS5441387A JPS5441387A JP9899777A JP9899777A JPS5441387A JP S5441387 A JPS5441387 A JP S5441387A JP 9899777 A JP9899777 A JP 9899777A JP 9899777 A JP9899777 A JP 9899777A JP S5441387 A JPS5441387 A JP S5441387A
- Authority
- JP
- Japan
- Prior art keywords
- bleomycin
- medium
- diaminopropane
- phenylethyl
- precursor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960001561 bleomycin Drugs 0.000 title abstract 3
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical class N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 abstract 4
- 108010006654 Bleomycin Proteins 0.000 abstract 3
- 241000233866 Fungi Species 0.000 abstract 2
- 241000187747 Streptomyces Species 0.000 abstract 2
- 230000003327 cancerostatic effect Effects 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 241001147844 Streptomyces verticillus Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- NQONXAAXIFYYMX-JTQLQIEISA-N n'-[(1s)-1-phenylethyl]propane-1,3-diamine Chemical compound NCCCN[C@@H](C)C1=CC=CC=C1 NQONXAAXIFYYMX-JTQLQIEISA-N 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9899777A JPS5441387A (en) | 1977-08-18 | 1977-08-18 | Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin |
| DK267478A DK148808C (da) | 1977-08-18 | 1978-06-14 | Fremgangsmaade til fremstilling af 3-((s)-1'-phenylethylamino)propylaminobleomycin |
| CS784304A CS210673B2 (en) | 1977-08-18 | 1978-06-29 | Manufacturing process of 3-(ls)p-1 - phenylethylamino prropylaminobleomycine |
| ES471297A ES471297A1 (es) | 1977-08-18 | 1978-06-30 | Un procedimiento para la obtencion de 3-((s)-1'feniletilami-no) propilamino-bleomicina |
| HU78NI217A HU179556B (en) | 1977-08-18 | 1978-07-03 | Process for producing 3-square bracket-bracket-s-bracket closed 1-comma above-phenyl-ethyl-amino-square bracket closed-propyl-amino-bleomycin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9899777A JPS5441387A (en) | 1977-08-18 | 1977-08-18 | Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5441387A true JPS5441387A (en) | 1979-04-02 |
| JPS5739752B2 JPS5739752B2 (enrdf_load_stackoverflow) | 1982-08-23 |
Family
ID=14234606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9899777A Granted JPS5441387A (en) | 1977-08-18 | 1977-08-18 | Preparation of 3-(s)-1'phenylethylamino-proplyamino-bleomycin |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5441387A (enrdf_load_stackoverflow) |
| CS (1) | CS210673B2 (enrdf_load_stackoverflow) |
| DK (1) | DK148808C (enrdf_load_stackoverflow) |
| ES (1) | ES471297A1 (enrdf_load_stackoverflow) |
| HU (1) | HU179556B (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54124692U (enrdf_load_stackoverflow) * | 1978-02-20 | 1979-08-31 | ||
| CN107434822A (zh) * | 2016-05-25 | 2017-12-05 | 国科戎安生物科技（北京）有限公司 | 博来霉素衍生物及制备方法和应用 |
| CN107434821A (zh) * | 2016-05-25 | 2017-12-05 | 国科戎安生物科技（北京）有限公司 | 一种111铟‑博来霉素衍生物的螯合物及应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62129961U (enrdf_load_stackoverflow) * | 1986-02-13 | 1987-08-17 | ||
| JPS62129960U (enrdf_load_stackoverflow) * | 1986-02-13 | 1987-08-17 |
-
1977
- 1977-08-18 JP JP9899777A patent/JPS5441387A/ja active Granted
-
1978
- 1978-06-14 DK DK267478A patent/DK148808C/da not_active IP Right Cessation
- 1978-06-29 CS CS784304A patent/CS210673B2/cs unknown
- 1978-06-30 ES ES471297A patent/ES471297A1/es not_active Expired
- 1978-07-03 HU HU78NI217A patent/HU179556B/hu not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54124692U (enrdf_load_stackoverflow) * | 1978-02-20 | 1979-08-31 | ||
| CN107434822A (zh) * | 2016-05-25 | 2017-12-05 | 国科戎安生物科技（北京）有限公司 | 博来霉素衍生物及制备方法和应用 |
| CN107434821A (zh) * | 2016-05-25 | 2017-12-05 | 国科戎安生物科技（北京）有限公司 | 一种111铟‑博来霉素衍生物的螯合物及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| DK267478A (da) | 1979-02-19 |
| JPS5739752B2 (enrdf_load_stackoverflow) | 1982-08-23 |
| CS210673B2 (en) | 1982-01-29 |
| DK148808B (da) | 1985-10-07 |
| DK148808C (da) | 1986-04-14 |
| ES471297A1 (es) | 1979-01-16 |
| HU179556B (en) | 1982-11-29 |
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