JPS54135796A - Preparation of ansamytocins - Google Patents
Preparation of ansamytocinsInfo
- Publication number
- JPS54135796A JPS54135796A JP4394678A JP4394678A JPS54135796A JP S54135796 A JPS54135796 A JP S54135796A JP 4394678 A JP4394678 A JP 4394678A JP 4394678 A JP4394678 A JP 4394678A JP S54135796 A JPS54135796 A JP S54135796A
- Authority
- JP
- Japan
- Prior art keywords
- carbodiimide
- formula
- carboxylic acid
- maytansinol
- ansamytocins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001718 carbodiimides Chemical class 0.000 abstract 4
- QWPXBEHQFHACTK-KZVYIGENSA-N (10e,12e)-86-chloro-12,14,4-trihydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-15,16-dihydro-14h-7-aza-1(6,4)-oxazina-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-6-one Chemical compound CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-KZVYIGENSA-N 0.000 abstract 3
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 3
- 238000005917 acylation reaction Methods 0.000 abstract 2
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 230000000842 anti-protozoal effect Effects 0.000 abstract 1
- 239000003904 antiprotozoal agent Substances 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4394678A JPS54135796A (en) | 1978-04-13 | 1978-04-13 | Preparation of ansamytocins |
| US06/021,702 US4265814A (en) | 1978-03-24 | 1979-03-19 | Matansinol 3-n-hexadecanoate |
| FR7907337A FR2431498A1 (fr) | 1978-03-24 | 1979-03-22 | Procede de preparation de maytansinoides et produits obtenus par ce procede |
| DE19792911248 DE2911248A1 (de) | 1978-03-24 | 1979-03-22 | Herstellung von maytansinoiden und maytansinoide |
| GB7910299A GB2017101B (en) | 1978-03-24 | 1979-03-23 | Production of maytansinoids |
| CA324,030A CA1102798A (en) | 1978-03-24 | 1979-03-23 | Production of maytansinoids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4394678A JPS54135796A (en) | 1978-04-13 | 1978-04-13 | Preparation of ansamytocins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS54135796A true JPS54135796A (en) | 1979-10-22 |
| JPS6154799B2 JPS6154799B2 (enrdf_load_stackoverflow) | 1986-11-25 |
Family
ID=12677862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4394678A Granted JPS54135796A (en) | 1978-03-24 | 1978-04-13 | Preparation of ansamytocins |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS54135796A (enrdf_load_stackoverflow) |
-
1978
- 1978-04-13 JP JP4394678A patent/JPS54135796A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6154799B2 (enrdf_load_stackoverflow) | 1986-11-25 |
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