JPS54135790A - Antibiotic substance ps-5 s-oxide - Google Patents

Antibiotic substance ps-5 s-oxide

Info

Publication number
JPS54135790A
JPS54135790A JP4179478A JP4179478A JPS54135790A JP S54135790 A JPS54135790 A JP S54135790A JP 4179478 A JP4179478 A JP 4179478A JP 4179478 A JP4179478 A JP 4179478A JP S54135790 A JPS54135790 A JP S54135790A
Authority
JP
Japan
Prior art keywords
antibiotic
gram
oxide
formula
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4179478A
Other languages
Japanese (ja)
Inventor
Kaoru Yamada
Yasutaka Shimauchi
Tomoyuki Ishikura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP4179478A priority Critical patent/JPS54135790A/en
Publication of JPS54135790A publication Critical patent/JPS54135790A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NEW MATERIAL:An antibiotic substance PS-5.S-oxide of formula I and its salt.
USE: Antibiotic agent, antibiotic activity improving agent, and their intermediate. Effective to Gram-positive and Gram-negative bacteria. Synergetically improves the effectivity of known β-lactam antibiotic substances to the resistant bacteria.
PROCESS: The compound I is prepared by (1) reacting a novel antibiotic substance PS-5 of formula II or its salt produced by Streptomyces sp-A271 (FERM-P No.3984, ATCC 31358) with a mild oxidizing agent such as m-chloroperbenzoic acid, etc. in an inert palar solvent such as water, CH3OH, etc. at 0W25°C for 3 minW3 hours, (2) adding a phosphate buffer solution to the filtrate, and (3) subjecting the buffered filtrate to a combination of the adsorption with Dia-ion HP-20 (product of Mitsubishi kasei kogyo kk) and the elution with CH3OH/water, etc.
COPYRIGHT: (C)1979,JPO&Japio
JP4179478A 1978-04-11 1978-04-11 Antibiotic substance ps-5 s-oxide Pending JPS54135790A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4179478A JPS54135790A (en) 1978-04-11 1978-04-11 Antibiotic substance ps-5 s-oxide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4179478A JPS54135790A (en) 1978-04-11 1978-04-11 Antibiotic substance ps-5 s-oxide

Publications (1)

Publication Number Publication Date
JPS54135790A true JPS54135790A (en) 1979-10-22

Family

ID=12618235

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4179478A Pending JPS54135790A (en) 1978-04-11 1978-04-11 Antibiotic substance ps-5 s-oxide

Country Status (1)

Country Link
JP (1) JPS54135790A (en)

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