JPS54110394A - Preparation of cephapirin - Google Patents
Preparation of cephapirinInfo
- Publication number
- JPS54110394A JPS54110394A JP1493378A JP1493378A JPS54110394A JP S54110394 A JPS54110394 A JP S54110394A JP 1493378 A JP1493378 A JP 1493378A JP 1493378 A JP1493378 A JP 1493378A JP S54110394 A JPS54110394 A JP S54110394A
- Authority
- JP
- Japan
- Prior art keywords
- pref
- aca
- cephapirin
- thioacetic acid
- arthrobacter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare cephapirin useful as an anti-bacterial agent, in high yield, by acylating 7-aminocephalosporanic acid (7-ACA) with 4-pyridine thioacetic acid in the presence of culturing product of bacteria belonging to Arthrobacter genus.
CONSTITUTION: Bacteria belonging to Arthrobacter genus and capable of producing an acylating enzyme, e.g. Arthrobacter viscosous ATCC 15924 are cutured in a medium. Cephapirin is prepared by the acylation reaction of 7-ACA and 4-pyridyl thioacetic acid or its reactive erivative (pref. methyl ester) in the presence of the above cultured product or the cultured medium, at 30W45°C, pref. 35W40°C and pH6.5W8, pref. 6.8W7.2 for 1W5 hours. The concentration of 7-ACA in the reaction mixture is 5W50 mg/ml, pref. 15W30 mg/ml, and the molar ratio of pyridyl thioacetic acid to 7-AVA is 1W20, pref. 2W5.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1493378A JPS54110394A (en) | 1978-02-14 | 1978-02-14 | Preparation of cephapirin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1493378A JPS54110394A (en) | 1978-02-14 | 1978-02-14 | Preparation of cephapirin |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54110394A true JPS54110394A (en) | 1979-08-29 |
JPS5549840B2 JPS5549840B2 (en) | 1980-12-15 |
Family
ID=11874759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1493378A Granted JPS54110394A (en) | 1978-02-14 | 1978-02-14 | Preparation of cephapirin |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54110394A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
US5229274A (en) * | 1989-06-27 | 1993-07-20 | Merck & Co., Inc. | Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus |
-
1978
- 1978-02-14 JP JP1493378A patent/JPS54110394A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
US5229274A (en) * | 1989-06-27 | 1993-07-20 | Merck & Co., Inc. | Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus |
Also Published As
Publication number | Publication date |
---|---|
JPS5549840B2 (en) | 1980-12-15 |
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