JPS5441388A - Preparation of cephradine - Google Patents

Preparation of cephradine

Info

Publication number
JPS5441388A
JPS5441388A JP10726877A JP10726877A JPS5441388A JP S5441388 A JPS5441388 A JP S5441388A JP 10726877 A JP10726877 A JP 10726877A JP 10726877 A JP10726877 A JP 10726877A JP S5441388 A JPS5441388 A JP S5441388A
Authority
JP
Japan
Prior art keywords
adca
pref
cephradine
bacterial cell
bacteria belonging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10726877A
Other languages
Japanese (ja)
Inventor
Hideo Takeda
Ikuo Matsumoto
Isao Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP10726877A priority Critical patent/JPS5441388A/en
Publication of JPS5441388A publication Critical patent/JPS5441388A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare cephradine useful as an antibacterial agent, by the acylation of 7-aminodesacetoxycephalosporanic acid (7-ADCA) in the presence of an acylase produced by bacteria belonging to Acetobacter genus.
CONSTITUTION: Cephradine is prepared by (1) culturing bacteria belonging to Azotobacter genus, e.g. Anzotovacter No.5686 (FERM-P No.1661), fixing the bacterial cell obtained by separating from the medium followed by washing, or an enzyme existing in the bacterial cell, to a water-insoluble carrier such as actibated alumina, etc., to obtain an immobilized enzyme, and (3) acrylating 7-ADCA in a buffer solution containing D-α-(1,4-cyclohexadienyl)-glycine lower alkyl (pref. methyl) ester, in the presence of the above immobilized enzyme at 18W22°C, pH 6.8W7.2 for 1W15hr. The concentration of the 7-ADCA in the reaction system is 0.1W50mg/ml, pref. 5W20mg/ml, and the molar ratio of the glycine ester to the 7-ADCA is 2W20, pref. 1.5W4.
COPYRIGHT: (C)1979,JPO&Japio
JP10726877A 1977-09-08 1977-09-08 Preparation of cephradine Pending JPS5441388A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10726877A JPS5441388A (en) 1977-09-08 1977-09-08 Preparation of cephradine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10726877A JPS5441388A (en) 1977-09-08 1977-09-08 Preparation of cephradine

Publications (1)

Publication Number Publication Date
JPS5441388A true JPS5441388A (en) 1979-04-02

Family

ID=14454739

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10726877A Pending JPS5441388A (en) 1977-09-08 1977-09-08 Preparation of cephradine

Country Status (1)

Country Link
JP (1) JPS5441388A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57111298A (en) * 1980-12-29 1982-07-10 Fujitsu Ltd Growth of compound semiconductor layer and its device
JPS5990480A (en) * 1982-11-15 1984-05-24 Matsushita Electric Works Ltd Catv branching system
JPS63110538U (en) * 1987-01-13 1988-07-15

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57111298A (en) * 1980-12-29 1982-07-10 Fujitsu Ltd Growth of compound semiconductor layer and its device
JPS5990480A (en) * 1982-11-15 1984-05-24 Matsushita Electric Works Ltd Catv branching system
JPS63110538U (en) * 1987-01-13 1988-07-15
JPH0516193Y2 (en) * 1987-01-13 1993-04-28

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