JPS5441388A - Preparation of cephradine - Google Patents
Preparation of cephradineInfo
- Publication number
- JPS5441388A JPS5441388A JP10726877A JP10726877A JPS5441388A JP S5441388 A JPS5441388 A JP S5441388A JP 10726877 A JP10726877 A JP 10726877A JP 10726877 A JP10726877 A JP 10726877A JP S5441388 A JPS5441388 A JP S5441388A
- Authority
- JP
- Japan
- Prior art keywords
- adca
- pref
- cephradine
- bacterial cell
- bacteria belonging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare cephradine useful as an antibacterial agent, by the acylation of 7-aminodesacetoxycephalosporanic acid (7-ADCA) in the presence of an acylase produced by bacteria belonging to Acetobacter genus.
CONSTITUTION: Cephradine is prepared by (1) culturing bacteria belonging to Azotobacter genus, e.g. Anzotovacter No.5686 (FERM-P No.1661), fixing the bacterial cell obtained by separating from the medium followed by washing, or an enzyme existing in the bacterial cell, to a water-insoluble carrier such as actibated alumina, etc., to obtain an immobilized enzyme, and (3) acrylating 7-ADCA in a buffer solution containing D-α-(1,4-cyclohexadienyl)-glycine lower alkyl (pref. methyl) ester, in the presence of the above immobilized enzyme at 18W22°C, pH 6.8W7.2 for 1W15hr. The concentration of the 7-ADCA in the reaction system is 0.1W50mg/ml, pref. 5W20mg/ml, and the molar ratio of the glycine ester to the 7-ADCA is 2W20, pref. 1.5W4.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10726877A JPS5441388A (en) | 1977-09-08 | 1977-09-08 | Preparation of cephradine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10726877A JPS5441388A (en) | 1977-09-08 | 1977-09-08 | Preparation of cephradine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5441388A true JPS5441388A (en) | 1979-04-02 |
Family
ID=14454739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10726877A Pending JPS5441388A (en) | 1977-09-08 | 1977-09-08 | Preparation of cephradine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5441388A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57111298A (en) * | 1980-12-29 | 1982-07-10 | Fujitsu Ltd | Growth of compound semiconductor layer and its device |
JPS5990480A (en) * | 1982-11-15 | 1984-05-24 | Matsushita Electric Works Ltd | Catv branching system |
JPS63110538U (en) * | 1987-01-13 | 1988-07-15 |
-
1977
- 1977-09-08 JP JP10726877A patent/JPS5441388A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57111298A (en) * | 1980-12-29 | 1982-07-10 | Fujitsu Ltd | Growth of compound semiconductor layer and its device |
JPS5990480A (en) * | 1982-11-15 | 1984-05-24 | Matsushita Electric Works Ltd | Catv branching system |
JPS63110538U (en) * | 1987-01-13 | 1988-07-15 | ||
JPH0516193Y2 (en) * | 1987-01-13 | 1993-04-28 |
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