JPS54103887A - Preparation of 7-methoxy cephalosporin derivative - Google Patents

Preparation of 7-methoxy cephalosporin derivative

Info

Publication number
JPS54103887A
JPS54103887A JP799978A JP799978A JPS54103887A JP S54103887 A JPS54103887 A JP S54103887A JP 799978 A JP799978 A JP 799978A JP 799978 A JP799978 A JP 799978A JP S54103887 A JPS54103887 A JP S54103887A
Authority
JP
Japan
Prior art keywords
compound
formula
reacted
group
tetrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP799978A
Other languages
Japanese (ja)
Other versions
JPS6052710B2 (en
Inventor
Tetsuo Hiraoka
Masao Shiosaki
Kimio Iino
Noboru Ishida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP53007999A priority Critical patent/JPS6052710B2/en
Priority to ES477221A priority patent/ES477221A1/en
Priority to IT67192/79A priority patent/IT1119260B/en
Publication of JPS54103887A publication Critical patent/JPS54103887A/en
Publication of JPS6052710B2 publication Critical patent/JPS6052710B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound, which is an antibacterial, by treatment of the reaction product between cephamycin C and a tetrazole with an oxalyl halide and an alcohol, and by reduction, halogenation, and introduction of a cyanomethylthio group to exchange the acyl group at the 7β-position.
CONSTITUTION: A compound of formula I: (R1 is amino-protecting group) is reacted with 1-methyl-1H-5-mercapto-tetrazole and then an oxalyl halide, e.g. oxalyl chloride, in the presence of a base, e.g. Na2CO3, and treated with water to give a compound of formula II, which is reacted with a compound of the formula R2OH (R2 is lower alkyl group) in the presence of a mineral or Lewis acid, and reduced with a metal hydride to form a compound of formula III. The resulting compound is reacted with a halogenating or sulfonylating agent, then with a compound of the formula NCCH2S-M (M is alkali metal) to afford the objective cyanomethylthio derivative of formula IV.
COPYRIGHT: (C)1979,JPO&Japio
JP53007999A 1978-01-27 1978-01-27 Method for producing 7-methoxycephalosporin derivative Expired JPS6052710B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP53007999A JPS6052710B2 (en) 1978-01-27 1978-01-27 Method for producing 7-methoxycephalosporin derivative
ES477221A ES477221A1 (en) 1978-01-27 1979-01-26 Preparation of 77methoxy cephalosporin derivative
IT67192/79A IT1119260B (en) 1978-01-27 1979-01-29 PROCEDURE FOR THE PREPARATION OF THE DERIVATIVES OF THE -METHOXY-CEFALO SPORINA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53007999A JPS6052710B2 (en) 1978-01-27 1978-01-27 Method for producing 7-methoxycephalosporin derivative

Publications (2)

Publication Number Publication Date
JPS54103887A true JPS54103887A (en) 1979-08-15
JPS6052710B2 JPS6052710B2 (en) 1985-11-20

Family

ID=11681081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53007999A Expired JPS6052710B2 (en) 1978-01-27 1978-01-27 Method for producing 7-methoxycephalosporin derivative

Country Status (3)

Country Link
JP (1) JPS6052710B2 (en)
ES (1) ES477221A1 (en)
IT (1) IT1119260B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6242989A (en) * 1986-08-04 1987-02-24 Sumitomo Pharmaceut Co Ltd Production of 7alpha-methoxycephalosporin compound

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6242989A (en) * 1986-08-04 1987-02-24 Sumitomo Pharmaceut Co Ltd Production of 7alpha-methoxycephalosporin compound

Also Published As

Publication number Publication date
IT7967192A0 (en) 1979-01-29
ES477221A1 (en) 1980-03-01
IT1119260B (en) 1986-03-10
JPS6052710B2 (en) 1985-11-20

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