JPS51108075A - - Google Patents

Info

Publication number
JPS51108075A
JPS51108075A JP51017182A JP1718276A JPS51108075A JP S51108075 A JPS51108075 A JP S51108075A JP 51017182 A JP51017182 A JP 51017182A JP 1718276 A JP1718276 A JP 1718276A JP S51108075 A JPS51108075 A JP S51108075A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP51017182A
Other versions
JPS6025424B2 (ja
Inventor
Botsuzaato Furiitoritsuhi
Behingaa Ekuberuto
Suteperu Kuruto
Fuaataa Burufu
Ritsuda Sutanisurafu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS51108075A publication Critical patent/JPS51108075A/ja
Publication of JPS6025424B2 publication Critical patent/JPS6025424B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP51017182A 1975-02-26 1976-02-20 １，４‐ジヒドロピリジンカルボン酸アラルキルエステル Expired JPS6025424B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2508181.6 1975-02-26
DE19752508181 DE2508181A1 (de) 1975-02-26 1975-02-26 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
JPS51108075A true JPS51108075A (ja) 1976-09-25
JPS6025424B2 JPS6025424B2 (ja) 1985-06-18

Family

ID=5939797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51017182A Expired JPS6025424B2 (ja) 1975-02-26 1976-02-20 １，４‐ジヒドロピリジンカルボン酸アラルキルエステル

Country Status (27)

Country Link
US (1) US4044141A (ja)
JP (1) JPS6025424B2 (ja)
AT (1) AT351024B (ja)
BE (1) BE838924A (ja)
CA (1) CA1069902A (ja)
CH (1) CH622506A5 (ja)
CS (1) CS188994B2 (ja)
DD (1) DD125483A5 (ja)
DE (1) DE2508181A1 (ja)
DK (1) DK78876A (ja)
ES (1) ES445508A1 (ja)
FI (1) FI61483C (ja)
FR (1) FR2302093A1 (ja)
GB (1) GB1477114A (ja)
HU (1) HU171717B (ja)
IE (1) IE42643B1 (ja)
IL (1) IL49095A (ja)
IN (1) IN142197B (ja)
LU (1) LU74424A1 (ja)
NL (1) NL7601823A (ja)
NO (1) NO146393C (ja)
PL (1) PL100906B1 (ja)
PT (1) PT64840B (ja)
RO (1) RO68479A (ja)
SE (1) SE7602317L (ja)
SU (1) SU574150A3 (ja)
ZA (1) ZA761118B (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687522A (en) * 1979-11-23 1981-07-16 Sandoz Ag Drug containing dihydropyridine compound
JPS577468A (en) * 1980-05-13 1982-01-14 Bayer Ag Novel 1,4-dihydropyridine compound
JPS57200364A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salt
JPS60500255A (ja) * 1982-11-24 1985-02-28 セルモル　ソシエテ　アノニム １，４―ジヒドロピリジンの新規エステル
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
JPH01151557A (ja) * 1988-11-15 1989-06-14 Otsuka Pharmaceut Co Ltd 降圧剤
JPH0368555A (ja) * 1988-10-27 1991-03-25 Yuhan Corp １，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
DE2837477A1 (de) * 1978-08-28 1980-03-13 Bayer Ag Sila-substituierte 1,4-dihydropyridin- derivate
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
JPS60248693A (ja) * 1984-04-19 1985-12-09 Nippon Shinyaku Co Ltd ピリジン誘導体及び製法
DE3424342A1 (de) * 1984-07-03 1986-01-09 Bayer Ag, 5090 Leverkusen 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridin-3,5-dicarbonsaeure-isopropyl-(2-(3-trifluormethylphenoxy)-ethyl)-ester, mehrere verfahren zu seiner herstellung sowie seine verwendung in arzneimitteln
JPS6143165A (ja) * 1984-08-07 1986-03-01 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体の製造法
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
US4595690A (en) * 1985-02-11 1986-06-17 Syntex (U.S.A.) Inc. Antihypertensive dihydropyridine derivatives
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
DE3601196A1 (de) * 1986-01-17 1987-07-23 Merck Patent Gmbh 1,4-dihydropyridine
DK114587A (da) * 1986-03-12 1987-09-13 Byk Gulden Lomberg Chem Fab Monocycliske esterderivater
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
JPH0688973B2 (ja) * 1987-03-12 1994-11-09 京都薬品工業株式会社 １，４−ジヒドロピリジン誘導体
HUT48461A (en) * 1987-12-11 1989-06-28 Syntex Lab Process for producing pharmaceutical compositions containing 1,4-dihydropyridine derivatives
EP0330470A3 (en) * 1988-02-24 1992-01-02 Ajinomoto Co., Inc. 1,4-dihydropyridine derivatives useful against tumour cells
US5216172A (en) * 1988-02-24 1993-06-01 Ajinomoto Co., Inc. 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
GB9119983D0 (en) * 1991-09-19 1991-11-06 Erba Carlo Spa Dihydropyridine derivatives useful in antitumor therapy
DE4342193A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester
EE03192B1 (et) * 1993-12-10 1999-06-15 Bayer Aktiengesellschaft Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine
SE9600086D0 (sv) * 1996-01-10 1996-01-10 Astra Ab New manufacturing process
CN106380405B (zh) * 2016-08-24 2019-01-29 郑州瑞康制药有限公司 一种2-(3-硝基亚苄基)乙酰乙酸异丙酯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL77955C (ja) * 1948-11-17
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3996234A (en) * 1972-04-18 1976-12-07 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
JPS5649909B2 (ja) 1973-05-02 1981-11-25

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687522A (en) * 1979-11-23 1981-07-16 Sandoz Ag Drug containing dihydropyridine compound
JPH0138088B2 (ja) * 1979-11-23 1989-08-11 Sandoz Ag
JPS577468A (en) * 1980-05-13 1982-01-14 Bayer Ag Novel 1,4-dihydropyridine compound
JPS632431B2 (ja) * 1981-06-04 1988-01-19 Yoshitomi Pharmaceutical
JPS57200364A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salt
JPS60500255A (ja) * 1982-11-24 1985-02-28 セルモル　ソシエテ　アノニム １，４―ジヒドロピリジンの新規エステル
JPH0559906B2 (ja) * 1982-11-24 1993-09-01 Cermol Sa
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
JPH0129187B2 (ja) * 1983-12-02 1989-06-08 Otsuka Pharma Co Ltd
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
JPH0368555A (ja) * 1988-10-27 1991-03-25 Yuhan Corp １，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤
JPH0565509B2 (ja) * 1988-10-27 1993-09-17 Ryukan Yoko Kk
JPH01151557A (ja) * 1988-11-15 1989-06-14 Otsuka Pharmaceut Co Ltd 降圧剤
JPH0319205B2 (ja) * 1988-11-15 1991-03-14 Otsuka Pharma Co Ltd

Also Published As

Publication number Publication date
CA1069902A (en) 1980-01-15
ES445508A1 (es) 1977-11-16
NO146393C (no) 1982-09-22
IL49095A (en) 1979-12-30
DE2508181C2 (ja) 1988-12-01
NL7601823A (nl) 1976-08-30
IN142197B (ja) 1977-06-11
LU74424A1 (ja) 1977-01-07
DK78876A (da) 1976-08-27
PT64840A (fr) 1976-03-01
PL100906B1 (pl) 1978-11-30
FR2302093B1 (ja) 1979-09-21
FR2302093A1 (fr) 1976-09-24
DE2508181A1 (de) 1976-09-09
ATA132976A (de) 1978-12-15
HU171717B (hu) 1978-03-28
NO146393B (no) 1982-06-14
IE42643L (en) 1976-08-26
AT351024B (de) 1979-07-10
RO68479A (ro) 1981-01-30
FI61483B (fi) 1982-04-30
PT64840B (fr) 1977-06-07
JPS6025424B2 (ja) 1985-06-18
IL49095A0 (en) 1976-04-30
ZA761118B (en) 1977-02-23
FI61483C (fi) 1982-08-10
DD125483A5 (ja) 1977-04-20
BE838924A (fr) 1976-08-25
FI760475A (ja) 1976-08-27
AU1143876A (en) 1977-09-01
CH622506A5 (ja) 1981-04-15
SE7602317L (sv) 1976-08-27
CS188994B2 (en) 1979-03-30
GB1477114A (en) 1977-06-22
SU574150A3 (ru) 1977-09-25
US4044141A (en) 1977-08-23
IE42643B1 (en) 1980-09-24
NO760470L (ja) 1976-08-27

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