|
DE2856393C2
(de)
*
|
1978-12-27 |
1983-04-28 |
Merz + Co GmbH & Co, 6000 Frankfurt |
Arzneimittel zur Behandlung von Morbus Parkinson
|
|
US5506231A
(en)
*
|
1989-03-31 |
1996-04-09 |
The Children's Medical Center Corporation |
Treatment of aids dementia, myelopathy and blindness
|
|
US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
WO1992017168A1
(en)
*
|
1991-04-04 |
1992-10-15 |
The Children's Medical Center Corporation |
Method of preventing nmda receptor-mediated neuronal damage
|
|
US5455279A
(en)
*
|
1991-04-19 |
1995-10-03 |
The Children's Medical Center Corporation |
Regimen method of mediating neuronal damage using nitroglycerine
|
|
US5614560A
(en)
*
|
1991-04-04 |
1997-03-25 |
Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
DE4225730C2
(de)
*
|
1992-08-04 |
2003-04-30 |
Merz Pharma Gmbh & Co Kgaa |
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
|
|
US5866585A
(en)
*
|
1997-05-22 |
1999-02-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia using NMDA receptor antagonists
|
|
US6057373A
(en)
*
|
1997-05-22 |
2000-05-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
|
|
US5952389A
(en)
*
|
1998-01-13 |
1999-09-14 |
Synchroneuron |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US6294583B1
(en)
*
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US6444702B1
(en)
|
2000-02-22 |
2002-09-03 |
Neuromolecular, Inc. |
Aminoadamantane derivatives as therapeutic agents
|
|
US7250394B2
(en)
*
|
2001-08-20 |
2007-07-31 |
Maiken Nedergaard |
Treatment of glial tumors with glutamate antagonists
|
|
EP1298581A1
(fr)
*
|
2001-09-27 |
2003-04-02 |
C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa |
Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
|
|
CN100339070C
(zh)
|
2002-10-24 |
2007-09-26 |
莫茨药物股份两合公司 |
包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物
|
|
RU2246482C2
(ru)
*
|
2002-12-25 |
2005-02-20 |
ООО "Циклан" |
Способ получения гидрохлорида 1-амино-3,5-диметиладамантана
|
|
WO2005000216A2
(en)
*
|
2003-05-27 |
2005-01-06 |
Forest Laboratories, Inc. |
Combination of an nmda receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders
|
|
CN1240668C
(zh)
*
|
2003-09-10 |
2006-02-08 |
上海医药工业研究院 |
一种新的盐酸美金刚制备方法
|
|
US20050113458A1
(en)
*
|
2003-10-22 |
2005-05-26 |
Forest Laboratories, Inc. |
Use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic a-beta peptides in amyloidopathies
|
|
AR046314A1
(es)
|
2003-11-05 |
2005-11-30 |
Merz Pharma Gmbh & Co Kgaa |
Composiciones que comprenden ciclohexilaminas y aminoadamantanos
|
|
WO2005069742A2
(en)
*
|
2003-12-10 |
2005-08-04 |
Sun Pharmaceutical Industries Limited |
Crystal form ii of memantine hydrochloride
|
|
US20060020042A1
(en)
*
|
2004-01-05 |
2006-01-26 |
Forest Laboratories, Inc. |
Memantine for the treatment of mild and mild to moderate Alzheimer's disease
|
|
CN100363329C
(zh)
*
|
2004-01-09 |
2008-01-23 |
南京大学 |
合成美金刚胺盐酸盐的方法
|
|
US7456224B2
(en)
*
|
2004-04-05 |
2008-11-25 |
Forest Laboratories Holdings, Ltd. |
Method for treating autism
|
|
US20060002999A1
(en)
*
|
2004-06-17 |
2006-01-05 |
Forest Laboratories, Inc. |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
|
|
WO2006096194A2
(en)
|
2004-06-17 |
2006-09-14 |
Merz Pharma Gmbh & Co. Kgaa |
Drinkable immediate release tablet made with direct compression of memantine or neramexane
|
|
US8039009B2
(en)
*
|
2004-06-17 |
2011-10-18 |
Forest Laboratories Holdings Limited |
Modified release formulations of memantine oral dosage forms
|
|
TW200616608A
(en)
*
|
2004-07-09 |
2006-06-01 |
Forest Laboratories |
Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
|
|
AU2005286672B2
(en)
*
|
2004-09-23 |
2009-03-12 |
Merz Pharma Gmbh & Co. Kgaa |
Memantine for the treatment of childhood behavioral disorders
|
|
US20060205822A1
(en)
*
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
|
HRP20090676T1
(hr)
*
|
2005-01-11 |
2010-01-31 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Postupak dobivanja 1-amino-3,5-dimetiladamantan-hidroklorida
|
|
ITMI20050833A1
(it)
|
2005-05-10 |
2006-11-11 |
A M S A S P A Anonima Materie Sintetiche Affini |
Nuovo procedimento per la sintesi di aminoadamantani
|
|
CA2607600A1
(en)
*
|
2005-06-16 |
2006-12-28 |
Forest Laboratories, Inc. |
Modified and immediate release memantine bead formulation
|
|
AU2006275870B2
(en)
|
2005-07-27 |
2013-01-10 |
Otsuka America Pharmaceutical, Inc. |
Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
|
|
US20070099947A1
(en)
*
|
2005-11-03 |
2007-05-03 |
Alkermes, Inc. |
Methods and compositions for the treatment of brain reward system disorders by combination therapy
|
|
EP1820792B1
(en)
*
|
2006-02-21 |
2012-01-18 |
Hexal AG |
Process for the preparation of adamantanamines
|
|
ES2310504T1
(es)
*
|
2006-03-27 |
2009-01-16 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Procedimiento para la preparacion de clorhidrato de memantina sustancialmente libre de impurezas.
|
|
RU2450004C2
(ru)
|
2006-08-04 |
2012-05-10 |
Мерц Фарма Гмбх Унд Ко. Кгаа |
Замещенные пиразолопиримидины, способ их получения и их применение в качестве лекарственного средства
|
|
EP1908748A1
(en)
*
|
2006-10-05 |
2008-04-09 |
Krka |
Process for the preparation of memantine and its hydrochloric acid salt form
|
|
WO2008063847A2
(en)
*
|
2006-11-03 |
2008-05-29 |
Forest Laboratories Holdings Limited |
Method for treating autism
|
|
MX2009006672A
(es)
|
2006-12-19 |
2009-10-26 |
Univ Virginia |
Efectos combinados de topiramato y ondansetron sobre el consumo de alcohol.
|
|
CN101622243B
(zh)
|
2007-02-28 |
2013-12-04 |
旭化成制药株式会社 |
磺酰胺衍生物
|
|
US9133159B2
(en)
|
2007-06-06 |
2015-09-15 |
Neurovance, Inc. |
1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
EP2167083B1
(en)
|
2007-06-06 |
2015-10-28 |
Euthymics Bioscience, Inc. |
1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
GB0713930D0
(en)
|
2007-07-18 |
2007-08-29 |
Generics Uk Ltd |
Novel assay methods
|
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
|
US20090247644A1
(en)
*
|
2008-03-28 |
2009-10-01 |
Forest Laboratories Holdings Limited |
Memantine formulations
|
|
WO2009128058A1
(en)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Psycho-pharmaceuticals
|
|
EP2111858A1
(en)
|
2008-04-25 |
2009-10-28 |
EPFL Ecole Polytechnique Fédérale de Lausanne |
Novel treatment for alzheimer's disease
|
|
US20090275597A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Forest Laboratories Holdings Limited |
Methods of treating cns disorders
|
|
EP2138173A1
(en)
|
2008-06-26 |
2009-12-30 |
Merz Pharma GmbH & Co.KGaA |
Pharmaceutical compositions comprising aminoadamantane derivatives
|
|
HRP20090186A2
(hr)
|
2009-03-31 |
2010-10-31 |
Institut Ruđer Bošković |
Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
|
|
WO2010112221A1
(en)
|
2009-04-03 |
2010-10-07 |
Synthon B.V. |
Pharmaceutical compositions comprising memantine
|
|
CN102070463A
(zh)
*
|
2009-06-11 |
2011-05-25 |
辽宁利锋科技开发有限公司 |
具有金刚烷结构药物美金刚胺及其衍生物和类似物抗肿瘤新适应症的应用
|
|
TW201116532A
(en)
|
2009-08-05 |
2011-05-16 |
Merz Pharma Gmbh & Co Kgaa |
Metabotropic glutamate receptor modulators
|
|
US8741343B2
(en)
|
2009-12-02 |
2014-06-03 |
Adamas Pharmaceuticals, Inc. |
Method of administering amantadine prior to a sleep period
|
|
US20110251239A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
|
WO2012052451A1
(en)
|
2010-10-18 |
2012-04-26 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
KR20130132829A
(ko)
|
2010-10-29 |
2013-12-05 |
메르츠 파마 게엠베하 운트 코. 카가아 |
인돌 유도체 및 이의 제조 방법
|
|
JP5916746B2
(ja)
|
2010-11-15 |
2016-05-11 |
エージンバイオ， インコーポレイテッド |
認知障害を処置するためのピリダジン誘導体、組成物、および方法
|
|
WO2012085167A1
(en)
|
2010-12-22 |
2012-06-28 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
WO2012085166A1
(en)
|
2010-12-22 |
2012-06-28 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
CN102241678B
(zh)
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
WO2012152854A1
(en)
|
2011-05-12 |
2012-11-15 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
WO2012172093A1
(en)
|
2011-06-17 |
2012-12-20 |
Merz Pharma Gmbh & Co. Kgaa |
Dihydroindolizine derivate as metabotropic glutamate receptor modulators
|
|
US20140206740A1
(en)
|
2011-07-30 |
2014-07-24 |
Neurovance, Inc. |
Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
|
|
CN103288650B
(zh)
*
|
2012-02-28 |
2015-09-30 |
广州白云山制药股份有限公司广州白云山制药总厂 |
一种盐酸1-氨基-3,5-二甲基金刚烷的制备方法
|
|
EP2650284A1
(en)
|
2012-04-10 |
2013-10-16 |
Merz Pharma GmbH & Co. KGaA |
Heterocyclic derivatives as metabotropic glutamate receptor modulators
|
|
RU2488388C1
(ru)
|
2012-05-24 |
2013-07-27 |
Ооо "Валента Интеллект" |
Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
|
|
US10154971B2
(en)
|
2013-06-17 |
2018-12-18 |
Adamas Pharma, Llc |
Methods of administering amantadine
|
|
US9566264B2
(en)
|
2013-07-01 |
2017-02-14 |
Euthymics Bioscience, Inc. |
Combinations and methods
|
|
AU2014368961B2
(en)
|
2013-12-20 |
2019-10-17 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
CA2938671A1
(en)
|
2014-02-04 |
2015-08-13 |
Forest Laboratories Holdings Limited |
Donepezil compositions and method of treating alzheimer's disease
|
|
EP3310785B1
(en)
|
2015-06-19 |
2024-11-20 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
IL260290B2
(en)
|
2015-12-30 |
2023-11-01 |
Corium Inc |
Systems and methods for long-term percutaneous administration
|
|
US11541018B2
(en)
|
2016-06-23 |
2023-01-03 |
Corium, Llc |
Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
|
|
MX2019001104A
(es)
|
2016-07-27 |
2019-10-02 |
Corium Int Inc |
Sistemas de suministro transdermico de memantina.
|
|
JP7153010B2
(ja)
|
2016-07-27 |
2022-10-13 |
コリウム， インコーポレイテッド |
塩薬物のｉｎ ｓｉｔｕでの塩から中性の薬物変換による、低溶解度または不安定非イオン化中性薬物の経皮配合物および送達方法
|
|
CN109789134A
(zh)
|
2016-07-27 |
2019-05-21 |
考里安国际公司 |
与口服递送药代动力学生物等效的透皮递送系统
|
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
|
CA3086163A1
(en)
|
2017-12-20 |
2019-06-27 |
Corium, Inc. |
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
|
|
MX2020013927A
(es)
|
2018-06-19 |
2021-03-02 |
Agenebio Inc |
Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo.
|
|
WO2021232232A1
(zh)
*
|
2020-05-19 |
2021-11-25 |
山东泓瑞医药科技股份公司 |
一种金刚烷胺的制备方法
|
|
WO2024039886A1
(en)
|
2022-08-19 |
2024-02-22 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|