JPH11514231A - 細胞にhiv重感染に対する抵抗性を与える組成物および方法 - Google Patents
細胞にhiv重感染に対する抵抗性を与える組成物および方法Info
- Publication number
- JPH11514231A JPH11514231A JP9514894A JP51489497A JPH11514231A JP H11514231 A JPH11514231 A JP H11514231A JP 9514894 A JP9514894 A JP 9514894A JP 51489497 A JP51489497 A JP 51489497A JP H11514231 A JPH11514231 A JP H11514231A
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.HIVの重感染に対する抵抗性を細胞に与えるために、ヒトの細胞の核ゲ ノムの少なくとも1部に、非欠損性、非生産性のHIV変種ゲノムを安定に組み 込むのに充分な量で、かつ該細胞中で該非欠損性、非生産性のHIV変種を発現 するのに充分な量で、非欠損性、非生産性のHIV変種からのゲノムを含むレト ロウイルスベクター、を含む組成物。 2.非欠損性、非生産性のHIV変種ゲノムは、細胞の核ゲノムの少なくとも 約1%に組み込まれる、請求の範囲第1項に記載の組成物。 3.非欠損性、非生産性のHIV変種ゲノムは、細胞の核ゲノムの約1%〜約 10%に組み込まれる、請求の範囲第2項に記載の組成物。 4.標的細胞はT細胞である、前記請求の範囲のいずれか1項に記載の組成物 。 5.非欠損性、非生産性のHIV変種からのゲノムはF12−HIVのゲノム である、前記請求の範囲のいずれか1項に記載の組成物。 6.F12−HIVゲノムの3’LTRは欠失している、請求の範囲第5項に 記載の組成物。 7.F12−HIVゲノムは、アンチセンスの方向でレトロウイルスベクター に挿入される、請求の範囲第6項に記載の組成物。 8.レトロウイルスベクターは、モロニーマウス白血病ウイルスから誘導され るベクターである、前記請求の範囲のいずれか1項に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT95A000667 | 1995-10-09 | ||
IT95RM000667A IT1276215B1 (it) | 1995-10-09 | 1995-10-09 | Composizione e metodo per conferire resistenza cellulare alla superinfezione con hiv |
PCT/IT1996/000185 WO1997013861A1 (en) | 1995-10-09 | 1996-10-08 | Composition and method of imparting resistivity to hiv superinfection to cells |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11514231A true JPH11514231A (ja) | 1999-12-07 |
JP3805371B2 JP3805371B2 (ja) | 2006-08-02 |
Family
ID=11403603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51489497A Expired - Fee Related JP3805371B2 (ja) | 1995-10-09 | 1996-10-08 | 細胞にhiv重感染に対する抵抗性を与える組成物および方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6429009B1 (ja) |
EP (1) | EP0859847B1 (ja) |
JP (1) | JP3805371B2 (ja) |
AT (1) | ATE264915T1 (ja) |
AU (1) | AU7331996A (ja) |
DE (1) | DE69632263T2 (ja) |
ES (1) | ES2220994T3 (ja) |
IT (1) | IT1276215B1 (ja) |
WO (1) | WO1997013861A1 (ja) |
-
1995
- 1995-10-09 IT IT95RM000667A patent/IT1276215B1/it active IP Right Grant
-
1996
- 1996-10-08 DE DE69632263T patent/DE69632263T2/de not_active Expired - Lifetime
- 1996-10-08 EP EP96935323A patent/EP0859847B1/en not_active Expired - Lifetime
- 1996-10-08 AT AT96935323T patent/ATE264915T1/de not_active IP Right Cessation
- 1996-10-08 ES ES96935323T patent/ES2220994T3/es not_active Expired - Lifetime
- 1996-10-08 AU AU73319/96A patent/AU7331996A/en not_active Abandoned
- 1996-10-08 US US09/051,231 patent/US6429009B1/en not_active Expired - Fee Related
- 1996-10-08 WO PCT/IT1996/000185 patent/WO1997013861A1/en active IP Right Grant
- 1996-10-08 JP JP51489497A patent/JP3805371B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6429009B1 (en) | 2002-08-06 |
ES2220994T3 (es) | 2004-12-16 |
IT1276215B1 (it) | 1997-10-27 |
DE69632263T2 (de) | 2005-06-02 |
DE69632263D1 (de) | 2004-05-27 |
AU7331996A (en) | 1997-04-30 |
ITRM950667A1 (it) | 1997-04-09 |
ITRM950667A0 (ja) | 1995-10-09 |
ATE264915T1 (de) | 2004-05-15 |
JP3805371B2 (ja) | 2006-08-02 |
EP0859847B1 (en) | 2004-04-21 |
WO1997013861A1 (en) | 1997-04-17 |
EP0859847A1 (en) | 1998-08-26 |
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