JPH11511735A - 非細胞性(Acellular)百日咳ワクチン及びその調製方法 - Google Patents
非細胞性(Acellular)百日咳ワクチン及びその調製方法Info
- Publication number
- JPH11511735A JPH11511735A JP8532883A JP53288396A JPH11511735A JP H11511735 A JPH11511735 A JP H11511735A JP 8532883 A JP8532883 A JP 8532883A JP 53288396 A JP53288396 A JP 53288396A JP H11511735 A JPH11511735 A JP H11511735A
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- pertussis
- toxoid
- nitrogen
- agglutinogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. B .Pertussisに感染することにより惹起される疾病症例に対して危険のあ る人々を防護するためののワクチン組成物において、これがB .pertussisの、百 日咳トキソイドと、糸状赤血球凝集素と、ペルタクチンと、及び凝集原とを、上 記危険のある人々の少なくとも約70%の範囲までに防護をもたらす選択的な相 対量で精製された形で含む、上記ワクチン組成物。 2. 人への単一投与量の中に上記百日咳トキソイドが約5ないし約30μgの 窒素の量で、上記糸状赤血球凝集素が約5ないし約30μgの窒素の量で、上記 ペルタンチンが約3ないし約15μgの窒素の量で、そして上記凝集原が約1な いし約10μgの窒素の量で存在している、請求の範囲1のワクチン。 3. 人への単一投与量の中に、百日咳トキソイドの約10μgの窒素、糸状赤 血球凝集素の約5μgの窒素、ペルタンチンの約5μgの窒素、及び凝集原の約 3μgの窒素が含まれている、請求の範囲2のワクチン。 4. 人への単一投与量の中に、百日咳トキソイドの約20μgの窒素、糸状赤 血球凝集素の約20μgの窒素、ペルタンチンの約5μgの窒素、及び凝集原の 約3μgの窒素が含まれている、請求の範囲2のワクチン。 5. 少なくとも21日間の長さの痙攣性咳き込み及び確認された細菌感染を有 する百日咳の症例について防護範囲が少なくとも約80%である請求の範囲1の ワクチン。 6. 少なくとも1日間の長さの咳き込みを有する温和な百日咳の症例について 防護の範囲が少なくとも約70%である、請求の範囲1のワクチン。 7. 少なくとも21日間の痙攣性咳き込み及び確認された細菌感染を有する症 例について防護の範囲が約85%である、請求の範囲2のワクチン。 8. 上記凝集原が実質的に凝集原1を含まず、線毛性凝集原2(Agg2)及び 線毛性凝集原3(Agg3)を含む、請求の範囲1のワクチン。 9. Agg2のAgg3に対する重量比が約1.5:1から約2:1までである、請 求の範囲8のワクチン。 10. 更に、破傷風トキソイド及びジフテリヤトキソイドを含む、請求の範囲 1のワクチン。 11. 上記ジフテリヤトキソイドが15Lfの量で、そして破傷風トキソイドが約 5Lfの量で存在している、請求の範囲10のワクチン。 12. 更に、アジュバントを含む、請求の範囲1のワクチン。 13. アジュバントがアラムである、請求の範囲12のワクチン。 14. B .pertussisによる感染によって惹起される疾病に対して危険を有する 人々を免疫化する方法において、それら危険のある人々に、請求の範囲1のワク チン組成物の免疫効果量を投与してそれら危険のある人々の少なくとも約70% の範囲までに防護をもたらすことを含む、上記免疫化方法。 15. 感染の危険のある人々に投与するためのワクチン組成物の製造に用いた ときに上記危険のある人々の少なくとも約70%の範囲までに防護をもたらす、B .pertussis の、精製された形の百日咳毒素、糸状赤血球凝集素、ペルタクチン 及び線毛性凝集原。 16. 人への単一投与量のワクチン組成物の製造において、上記百日咳トキソ イドの約5から約30μgまでの窒素と、上記糸状赤血球凝集素の約5ないし約 30μgの窒素と、ペルタクチンの約3ないし約15μgの窒素と、及び線毛性 凝集原の約1ないし約10μgの窒素とが用いられる、請求の範囲15の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/433,646 US5877298A (en) | 1995-05-04 | 1995-05-04 | Acellular pertussis vaccines and methods of preparing thereof |
US08/433,646 | 1995-05-04 | ||
PCT/CA1996/000278 WO1996034623A1 (en) | 1995-05-04 | 1996-05-02 | Acellular pertussis vaccines and methods of preparation thereof |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2004043505A Division JP2004189751A (ja) | 1995-05-04 | 2004-02-19 | 非細胞性(Acellular)百日咳ワクチン及びその調製方法 |
Publications (2)
Publication Number | Publication Date |
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JPH11511735A true JPH11511735A (ja) | 1999-10-12 |
JP3977420B2 JP3977420B2 (ja) | 2007-09-19 |
Family
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JP53288396A Expired - Lifetime JP3977420B2 (ja) | 1995-05-04 | 1996-05-02 | 非細胞性(Acellular)百日咳ワクチン及びその調製方法 |
JP53288496A Expired - Lifetime JP3789135B2 (ja) | 1995-05-04 | 1996-05-02 | 凝集原製剤およびその製剤方法 |
JP2004043505A Pending JP2004189751A (ja) | 1995-05-04 | 2004-02-19 | 非細胞性(Acellular)百日咳ワクチン及びその調製方法 |
JP2005275654A Expired - Lifetime JP4589852B2 (ja) | 1995-05-04 | 2005-09-22 | 非細胞性百日咳ワクチンおよびその製造方法 |
JP2007322429A Expired - Lifetime JP4980868B2 (ja) | 1995-05-04 | 2007-12-13 | 非細胞性百日咳ワクチンおよびその製造方法 |
JP2010127128A Pending JP2010195829A (ja) | 1995-05-04 | 2010-06-02 | 非細胞性百日咳ワクチンおよびその製造方法 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
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JP53288496A Expired - Lifetime JP3789135B2 (ja) | 1995-05-04 | 1996-05-02 | 凝集原製剤およびその製剤方法 |
JP2004043505A Pending JP2004189751A (ja) | 1995-05-04 | 2004-02-19 | 非細胞性(Acellular)百日咳ワクチン及びその調製方法 |
JP2005275654A Expired - Lifetime JP4589852B2 (ja) | 1995-05-04 | 2005-09-22 | 非細胞性百日咳ワクチンおよびその製造方法 |
JP2007322429A Expired - Lifetime JP4980868B2 (ja) | 1995-05-04 | 2007-12-13 | 非細胞性百日咳ワクチンおよびその製造方法 |
JP2010127128A Pending JP2010195829A (ja) | 1995-05-04 | 2010-06-02 | 非細胞性百日咳ワクチンおよびその製造方法 |
Country Status (4)
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US (1) | US5877298A (ja) |
JP (6) | JP3977420B2 (ja) |
CN (1) | CN1915424A (ja) |
ES (1) | ES2359806T3 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008504802A (ja) * | 2003-11-20 | 2008-02-21 | サノフィ パストゥール インコーポレイテッド | 百日咳毒素を精製する方法およびそれに有用なペプチド |
JP2016510056A (ja) * | 2013-03-08 | 2016-04-04 | クルセル ホランド ベー ヴェー | 無細胞百日咳ワクチン |
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US6444211B2 (en) * | 1991-04-03 | 2002-09-03 | Connaught Laboratories, Inc. | Purification of a pertussis outer membrane protein |
FR2728170A1 (fr) * | 1994-12-15 | 1996-06-21 | Pasteur Institut | Vaccin de type acellulaire anti-bordetella |
US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
ES2182971T3 (es) * | 1995-05-04 | 2003-03-16 | Aventis Pasteur | Vacunas de pertussis acelulares y metodos de preparacion de las mismas. |
US20030157129A1 (en) * | 1995-06-23 | 2003-08-21 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen - carrier protein conjugate and free carrier protein |
AU769539B2 (en) * | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
EP1210131A4 (en) * | 1999-07-13 | 2005-05-25 | Deuk Hun Ahn | HERBAL DRUG COMPOSITION INTENDED FOR APPLICATION TO A WOMEN'S HYGIENIC TOWEL |
DE602004010376T2 (de) * | 2003-03-13 | 2008-10-23 | Glaxosmithkline Biologicals S.A. | Verfahren zur reinigung von bakteriellem cytolysin |
US7517968B2 (en) * | 2003-07-07 | 2009-04-14 | Syracuse University | Rapid and inexpensive method for the purification of proteorhodopsin |
WO2009094006A2 (en) * | 2007-10-25 | 2009-07-30 | Wake Forest University Health Sciences | Bordetella outer-membrane protein antigens and methods of making and using the same |
PE20100366A1 (es) * | 2008-10-24 | 2010-05-21 | Panacea Biotec Ltd | Novedosas composiciones de vacuna con tos ferina acelular asi como el metodo para su elaboracion |
US20100330158A1 (en) * | 2009-03-31 | 2010-12-30 | Innopharma, Llc | Protein-assisted drug delivery system for the targeted administration of active agents |
WO2010131111A1 (en) | 2009-05-11 | 2010-11-18 | Novartis Ag | Antigen purification process for pertactin antigen |
CN113151081A (zh) * | 2021-04-21 | 2021-07-23 | 深圳市儿童医院 | 一种百日咳鲍特菌培养基及其制备方法 |
CN113755380A (zh) * | 2021-09-23 | 2021-12-07 | 艾美卫信生物药业(浙江)有限公司 | 一种发酵生产白喉毒素crm197蛋白的菌种培养基、配制方法以及菌种复苏培养方法 |
CN117417419B (zh) * | 2023-01-10 | 2024-04-19 | 康希诺生物股份公司 | 一种百日咳毒素脱毒方法及无细胞百白破联合疫苗 |
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US4545986A (en) * | 1982-06-22 | 1985-10-08 | Research Corporation | Timothy grass antigen specific anti-idiotypic antibodies |
US4707358A (en) * | 1984-01-30 | 1987-11-17 | The University Of Chicago | Vaccine against Epstein-Barr Virus |
US5516512A (en) * | 1989-08-14 | 1996-05-14 | Gist-Brocades, N.V. | N- and C-terminal truncation and deletion mutants of human interleukin-3 |
US5276142A (en) * | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
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1995
- 1995-05-04 US US08/433,646 patent/US5877298A/en not_active Expired - Lifetime
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1996
- 1996-05-02 CN CNA2006101000485A patent/CN1915424A/zh active Pending
- 1996-05-02 JP JP53288396A patent/JP3977420B2/ja not_active Expired - Lifetime
- 1996-05-02 JP JP53288496A patent/JP3789135B2/ja not_active Expired - Lifetime
- 1996-05-02 ES ES03078355T patent/ES2359806T3/es not_active Expired - Lifetime
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- 2004-02-19 JP JP2004043505A patent/JP2004189751A/ja active Pending
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- 2005-09-22 JP JP2005275654A patent/JP4589852B2/ja not_active Expired - Lifetime
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- 2007-12-13 JP JP2007322429A patent/JP4980868B2/ja not_active Expired - Lifetime
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2008504802A (ja) * | 2003-11-20 | 2008-02-21 | サノフィ パストゥール インコーポレイテッド | 百日咳毒素を精製する方法およびそれに有用なペプチド |
JP2011173919A (ja) * | 2003-11-20 | 2011-09-08 | Sanofi Pasteur Inc | 百日咳毒素を精製する方法およびそれに有用なペプチド |
JP2016510056A (ja) * | 2013-03-08 | 2016-04-04 | クルセル ホランド ベー ヴェー | 無細胞百日咳ワクチン |
Also Published As
Publication number | Publication date |
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CN1915424A (zh) | 2007-02-21 |
JPH11507805A (ja) | 1999-07-13 |
JP4980868B2 (ja) | 2012-07-18 |
JP2010195829A (ja) | 2010-09-09 |
US5877298A (en) | 1999-03-02 |
JP3977420B2 (ja) | 2007-09-19 |
ES2359806T3 (es) | 2011-05-27 |
JP2006008711A (ja) | 2006-01-12 |
JP2008138003A (ja) | 2008-06-19 |
JP3789135B2 (ja) | 2006-06-21 |
JP4589852B2 (ja) | 2010-12-01 |
JP2004189751A (ja) | 2004-07-08 |
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