JPH11510803A - 免疫調節剤としての脂環式ジアミンの使用 - Google Patents
免疫調節剤としての脂環式ジアミンの使用Info
- Publication number
- JPH11510803A JPH11510803A JP9508177A JP50817797A JPH11510803A JP H11510803 A JPH11510803 A JP H11510803A JP 9508177 A JP9508177 A JP 9508177A JP 50817797 A JP50817797 A JP 50817797A JP H11510803 A JPH11510803 A JP H11510803A
- Authority
- JP
- Japan
- Prior art keywords
- group
- use according
- compound
- infection
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.免疫調節剤の調製のための、下記一般構造式: R−NH−K−Q−K−NH−R (I) (上式中、Qは下式II〜Vを有する二価の基を表し、 Kはメチレン基を表すか、または記号Qが式IIにより表される時には、Kは原 子価結合を表し、そして 記号Rは次の基VI〜XVIIから成る群より選ばれた基を表す: VI ベンジル VII 1個のハロゲンによりまたは1,2もしくは3個の トリハロメチル基により置換されたベンジル VIII 置換されたトリハロメチルベンジル IX インダニル X アルキル XI シクロアルキル XII シクロアルキルアルキル XIII アルケニル XIV シクロアルケニルアルキル XV ビシクロアルキル XVI ビシクロアルケニルアルキル XVII ビシクロアルキルアルキル) を有する化合物および有機または無機酸とのそれらの酸付加塩の使用。 2.前記免疫調節剤が、外因性または内因性病理学に関連づけられる機能不全 の場合にサイトカイン遺伝子および/またはサイトカイン受容体の発現を修正す ることを特徴とする、請求項1に記載の使用。 3.前記病理学がウイルス感染と関連づけられることを特徴とする、請求項2 に記載の使用。 4.前記病理学がリーシュマニア症、マラリアもしくはビルハルツ住血吸虫症 のような寄生虫感染症に関連づけられることを特徴とする、請求項2に記載の使 用。 5.例えばシクロスポリンのような免疫抑制剤の作用によりまたはコルチコイ ドの作用により誘発される、医原性起源の感染に関連づけられることを特徴とす る、請求項2に記載の使用。 6.血液学的腫瘍、例えばミエローマまたは組織腫瘍、のような腫瘍性起源の 感染に関連づけられることを特徴とする、請求項2に記載の使用。 7.前記病理学が自己免疫疾患である感染に関連づけられることを特徴とする 、請求項2に記載の使用。 8.前記病理学がHIV−I型またはII型によるウイルス性起源の感染に関連 づけられることを特徴とする、請求項3に記載の使用。 9.前記化合物が、Qが1,4−シクロヘキサンジ−イル基を表し、Kがメチ レン基を表し、そしてRがベンジル基;1個のハロゲンによりまたは1個、2個 もしくは3個のトリハロメチル基により置換されたベンジル基;あるいは置換さ れたトリハロメチルベンジル基を表す式Iを有することを特徴とする、請求項1 〜8のいずれか一項に記載の使用。 10.式(I)の化合物がトランス−1,4−ビス〔クロロベンジルアミノメチ ル〕シクロヘキサン二塩酸塩であることを特徴とする、請求項1〜8のいずれか 一項に記載の使用。 11.請求項1,9および10のいずれか一項において定義された化合物と抗ウイ ルス性を有する化合物との併用。 12.前記抗ウイルス性化合物がDDI、DDC、抗プロテアーゼ、3TCおよ びAZTから成る群より選ばれることを特徴とする、請求項11に記載の併用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR95/09459 | 1995-08-03 | ||
FR9509459A FR2737409B1 (fr) | 1995-08-03 | 1995-08-03 | Nouvelles utilisations de diamines alticycliques |
PCT/FR1996/001242 WO1997005859A2 (fr) | 1995-08-03 | 1996-08-02 | Utilisation de diamines alicycliques comme immunomodulateurs |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11510803A true JPH11510803A (ja) | 1999-09-21 |
JP4037450B2 JP4037450B2 (ja) | 2008-01-23 |
Family
ID=9481683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50817797A Expired - Fee Related JP4037450B2 (ja) | 1995-08-03 | 1996-08-02 | 免疫調節剤としての脂環式ジアミンの使用 |
Country Status (13)
Country | Link |
---|---|
US (1) | US6228890B1 (ja) |
EP (1) | EP0841909B1 (ja) |
JP (1) | JP4037450B2 (ja) |
CN (1) | CN1121214C (ja) |
AT (1) | ATE214273T1 (ja) |
AU (1) | AU6745096A (ja) |
BR (1) | BR9610077A (ja) |
CA (1) | CA2228689A1 (ja) |
DE (1) | DE69619827T2 (ja) |
ES (1) | ES2174094T3 (ja) |
FR (1) | FR2737409B1 (ja) |
PT (1) | PT841909E (ja) |
WO (1) | WO1997005859A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006514003A (ja) * | 2002-10-30 | 2006-04-27 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルベンジルアミド調節剤 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112691094B (zh) * | 2019-10-22 | 2022-09-23 | 中国科学院分子细胞科学卓越创新中心 | 防治病毒的新型化合物及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1387971A (fr) * | 1962-12-21 | 1965-02-05 | Ayerst Mckenna & Harrison | Nouvelles diamines alicycliques et leur procédé de préparation |
US3244750A (en) * | 1963-12-06 | 1966-04-05 | American Home Prod | Nu, nu'-disubstituted-aliphatic-bis-aminomethyl-cyclohexane derivatives |
US3202712A (en) * | 1963-02-05 | 1965-08-24 | American Home Prod | 1-cyclohexene-4-bis (omicron-chlorobenzylaminomethyl) and derivatives |
US4060639A (en) * | 1976-05-14 | 1977-11-29 | Merck & Co., Inc. | Broad spectrum antibacterial compositions containing tris-(hydroxymethyl)-aminoethane and dicycloaliphatic-alkyl polyamines |
US5116823A (en) * | 1990-02-27 | 1992-05-26 | Roger Williams General Hospital | Drug combinations containing AZT |
-
1995
- 1995-08-03 FR FR9509459A patent/FR2737409B1/fr not_active Expired - Fee Related
-
1996
- 1996-08-02 PT PT96927741T patent/PT841909E/pt unknown
- 1996-08-02 AU AU67450/96A patent/AU6745096A/en not_active Abandoned
- 1996-08-02 AT AT96927741T patent/ATE214273T1/de active
- 1996-08-02 WO PCT/FR1996/001242 patent/WO1997005859A2/fr active IP Right Grant
- 1996-08-02 ES ES96927741T patent/ES2174094T3/es not_active Expired - Lifetime
- 1996-08-02 CA CA002228689A patent/CA2228689A1/fr not_active Abandoned
- 1996-08-02 US US09/011,145 patent/US6228890B1/en not_active Expired - Lifetime
- 1996-08-02 EP EP96927741A patent/EP0841909B1/fr not_active Expired - Lifetime
- 1996-08-02 DE DE69619827T patent/DE69619827T2/de not_active Expired - Lifetime
- 1996-08-02 CN CN96196531A patent/CN1121214C/zh not_active Expired - Fee Related
- 1996-08-02 JP JP50817797A patent/JP4037450B2/ja not_active Expired - Fee Related
- 1996-08-02 BR BR9610077A patent/BR9610077A/pt not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006514003A (ja) * | 2002-10-30 | 2006-04-27 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルベンジルアミド調節剤 |
Also Published As
Publication number | Publication date |
---|---|
PT841909E (pt) | 2002-08-30 |
CN1193910A (zh) | 1998-09-23 |
ATE214273T1 (de) | 2002-03-15 |
EP0841909A2 (fr) | 1998-05-20 |
EP0841909B1 (fr) | 2002-03-13 |
CA2228689A1 (fr) | 1997-02-20 |
CN1121214C (zh) | 2003-09-17 |
DE69619827D1 (de) | 2002-04-18 |
AU6745096A (en) | 1997-03-05 |
DE69619827T2 (de) | 2002-11-07 |
FR2737409A1 (fr) | 1997-02-07 |
JP4037450B2 (ja) | 2008-01-23 |
US6228890B1 (en) | 2001-05-08 |
FR2737409B1 (fr) | 1997-10-24 |
ES2174094T3 (es) | 2002-11-01 |
WO1997005859A2 (fr) | 1997-02-20 |
WO1997005859A3 (fr) | 1997-03-27 |
BR9610077A (pt) | 1999-03-02 |
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