JPH11509090A - イオンチャンネル - Google Patents
イオンチャンネルInfo
- Publication number
- JPH11509090A JPH11509090A JP9504235A JP50423597A JPH11509090A JP H11509090 A JPH11509090 A JP H11509090A JP 9504235 A JP9504235 A JP 9504235A JP 50423597 A JP50423597 A JP 50423597A JP H11509090 A JPH11509090 A JP H11509090A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sodium channel
- sodium
- nucleic acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9486—Analgesics, e.g. opiates, aspirine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Thin Film Transistor (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Optical Communication System (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. ナトリウムチャンネルがテトロドトキシンに対して非感受性である、哺乳 動物感覚ニューロンナトリウムチャンネルタンパク質。 2. タンパク質が背根神経節に由来する、請求の範囲第1項記載のナトリウム チャンネルタンパク質。 3. ナトリウムチャンネルタンパク質がラットタンパク質である、請求の範囲 第2項記載のナトリウムチャンネルタンパク質。 4. ナトリウムチャンネルタンパク質がヒトタンパク質である、請求の範囲第 2項記載のナトリウムチャンネルタンパク質。 5. タンパク質が配列番号2、配列番号4、配列番号6または配列番号8に示 すアミノ酸配列を含む、請求の範囲第3項記載のナトリウムチャンネルタンパク 質。 6. タンパク質が配列番号2のアミノ酸配列を含む、請求の範囲第5項記載の ナトリウムチャンネルタンパク質。 7. タンパク質がNCIMB受託番号40744で寄託されたインサートによ ってコードされるアミノ酸配列を含む、請求の範囲第3項記載のナトリウムチャ ンネルタンパク質。 8. 請求の範囲第1項から第7項のナトリウムチャンネルタンパク質をコード する核酸配列またはその相補鎖。 9. 核酸配列が配列番号1、配列番号3、配列番号5または配列番号7に示す 核酸配列のコード部分を含む、請求の範囲第8項記載の核酸配列。 10. 核酸配列が配列番号1に示す核酸配列のコード部分を含む、請求の範囲 第9項記載の核酸配列。 11. 請求の範囲第8項または請求の範囲第10項の鎖にハイブリダイズする 核酸。 12. NCIMB受託番号40744で寄託されたインサートのコード部分の 配列を含むラット背根神経節ナトリウムチャンネルタンパク質をコードする核酸 配列またはその相補鎖。 13. 請求の範囲第8項〜第12項の核酸配列を含むベクター。 14. 請求の範囲第8項〜第12項の核酸配列で形質転換またはトランスフェ クトした宿主細胞。 15. テトロドトキシンに非感受性である哺乳動物背根神経節ナトリウムチャ ンネルの調節物質を同定するための方法であって、上記チャンネルに試験化合物 を接触させ、上記チャンネルの活性を検出することを含む方法。 16. 請求の範囲第1項記載のナトリウムチャンネルタンパク質に特異的な抗 体。 17. 請求の範囲第1項〜第7項記載のナトリウムチャンネルタンパク質をコ ードする核酸配列。 18. 請求の範囲第12項に定義した核酸配列を含む発現ベクター。 19. 請求の範囲第18項に定義した発現ベクターを含む宿主細胞。 20. 請求の範囲第1項〜第7項のいずれか1項に定義したナトリウムチャン ネルタンパク質の製造方法であって、請求の範囲第19項に定義した宿主細胞を ナトリウムチャンネルタンパク質の発現に好適な条件下で培養し、発現したナト リウムチャンネルタンパク質を所望により精製することを含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9513180.1 | 1995-06-28 | ||
GBGB9513180.1A GB9513180D0 (en) | 1995-06-28 | 1995-06-28 | Ion channel |
PCT/GB1996/001523 WO1997001577A1 (en) | 1995-06-28 | 1996-06-25 | Ion channel |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11509090A true JPH11509090A (ja) | 1999-08-17 |
Family
ID=10776812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9504235A Ceased JPH11509090A (ja) | 1995-06-28 | 1996-06-25 | イオンチャンネル |
Country Status (12)
Country | Link |
---|---|
US (3) | US6451554B1 (ja) |
EP (2) | EP0835261B1 (ja) |
JP (1) | JPH11509090A (ja) |
AT (1) | ATE235512T1 (ja) |
AU (1) | AU721798B2 (ja) |
CA (1) | CA2221294A1 (ja) |
DE (1) | DE69626984T2 (ja) |
DK (1) | DK0835261T3 (ja) |
ES (1) | ES2196158T3 (ja) |
GB (1) | GB9513180D0 (ja) |
PT (1) | PT835261E (ja) |
WO (1) | WO1997001577A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008517629A (ja) * | 2004-10-27 | 2008-05-29 | シェーリング コーポレイション | Nav1.8の短い干渉核酸阻害のための組成物および方法 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9513180D0 (en) * | 1995-06-28 | 1995-08-30 | Univ London | Ion channel |
US6184349B1 (en) | 1995-10-11 | 2001-02-06 | Syntex (Usa) Inc. | Cloned peripheral nerve, tetrodotoxin-resistant sodium channel α-subunit |
US6030810A (en) | 1997-02-26 | 2000-02-29 | Delgado; Stephen Gregory | Cloned tetrodotoxin-sensitive sodium channel α-subunit and a splice variant thereof |
EP0884386A1 (en) * | 1997-05-30 | 1998-12-16 | Synthelabo | Sodium channel receptor |
DE69836591T2 (de) * | 1997-10-29 | 2007-09-20 | Mcgill University, Montreal | Dna kodierend für einen humanen protonenabhängigen ionenkanal und deren verwendungen |
WO1999027097A2 (en) * | 1997-11-20 | 1999-06-03 | Medical College Of Georgia Research Institute, Inc. | CLONING OF A TETRODOTOXIN-RESISTANT SODIUM CHANNEL α-SUBUNIT |
CH693031A5 (de) * | 1997-11-20 | 2003-01-31 | Hoffmann La Roche | Nucleinsäure, die einen Nervengewebe-Natriumkanal kodiert. |
US6573067B1 (en) * | 1998-01-29 | 2003-06-03 | Yale University | Nucleic acid encoding sodium channels in dorsal root ganglia |
WO1999038889A2 (en) * | 1998-01-29 | 1999-08-05 | Yale University | Modulation of sodium channels in dorsal root ganglia |
GB9805793D0 (en) * | 1998-03-18 | 1998-05-13 | Glaxo Group Ltd | Sodium ion channels |
US20030228666A1 (en) * | 1998-06-30 | 2003-12-11 | Daewoong Pharmaceutical Co., Ltd. | Novel human thrombopoietin mutein |
JP4048053B2 (ja) * | 1999-11-26 | 2008-02-13 | マクギル ユニバーシティー | 特発性全身てんかんについてのローカス、当該ローカスのミューテーション、及びてんかんの評価、診断、予後、または治療のための当該ローカスの使用方法 |
GB0006024D0 (en) * | 2000-03-14 | 2000-05-03 | Glaxo Group Ltd | Altered ion channel proteins |
WO2002002608A2 (en) * | 2000-07-05 | 2002-01-10 | Neurosearch A/S | NEW SODIUM CHANNEL (rNaV1.5a) AND USE THEREOF |
JP4701374B2 (ja) * | 2000-08-04 | 2011-06-15 | 大学共同利用機関法人自然科学研究機構 | NaV2チャネル遺伝子欠損非ヒト動物 |
CN1269482C (zh) * | 2001-05-18 | 2006-08-16 | 威克斯医药有限公司 | 钠离子通道阻断剂和阿片类镇痛剂在制备用于对哺乳动物进行协同镇痛的药物中的应用 |
GB0120238D0 (en) | 2001-08-20 | 2001-10-10 | Univ College Of London | Sodium channel regulators and modulators |
CA2474751A1 (en) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
GB0211833D0 (en) * | 2002-05-22 | 2002-07-03 | Univ London | Sodium channel regulators and modulators |
GB2400103A (en) * | 2003-04-02 | 2004-10-06 | Ionix Pharmaceuticals Ltd | Cell lines expressing VGSC, Nav1.8 |
US20080020376A1 (en) * | 2004-03-10 | 2008-01-24 | Akopian Armen N | Enriched Cdna Expression Libraries and Methods of Making and Using Same |
TW200904981A (en) | 2007-06-08 | 2009-02-01 | Senomyx Inc | Identification of TRPML3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release |
CN105445476B (zh) * | 2015-12-17 | 2018-03-23 | 中山大学中山眼科中心 | 一种基于组织支架的三维视杯来源神经样细胞的钠离子通道检测方法 |
WO2023283618A1 (en) * | 2021-07-08 | 2023-01-12 | Children's Medical Center Corporation | Systems and methods for delivery based on supramolecular nanostructures |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009391A1 (en) | 1989-02-13 | 1990-08-23 | Arch Development Corporation | Nucleic acid encoding sodium channel protein |
US5380836A (en) | 1989-02-13 | 1995-01-10 | Arch Development Corporation | Nucleic acid encoding sodium channel protein |
GB9513180D0 (en) * | 1995-06-28 | 1995-08-30 | Univ London | Ion channel |
US6184349B1 (en) | 1995-10-11 | 2001-02-06 | Syntex (Usa) Inc. | Cloned peripheral nerve, tetrodotoxin-resistant sodium channel α-subunit |
-
1995
- 1995-06-28 GB GBGB9513180.1A patent/GB9513180D0/en active Pending
-
1996
- 1996-06-24 US US08/669,656 patent/US6451554B1/en not_active Expired - Fee Related
- 1996-06-25 EP EP96920970A patent/EP0835261B1/en not_active Revoked
- 1996-06-25 DK DK96920970T patent/DK0835261T3/da active
- 1996-06-25 ES ES96920970T patent/ES2196158T3/es not_active Expired - Lifetime
- 1996-06-25 DE DE69626984T patent/DE69626984T2/de not_active Revoked
- 1996-06-25 AT AT96920970T patent/ATE235512T1/de not_active IP Right Cessation
- 1996-06-25 EP EP02021422A patent/EP1281717A3/en not_active Ceased
- 1996-06-25 WO PCT/GB1996/001523 patent/WO1997001577A1/en not_active Application Discontinuation
- 1996-06-25 PT PT96920970T patent/PT835261E/pt unknown
- 1996-06-25 CA CA002221294A patent/CA2221294A1/en not_active Abandoned
- 1996-06-25 JP JP9504235A patent/JPH11509090A/ja not_active Ceased
- 1996-06-25 AU AU62345/96A patent/AU721798B2/en not_active Ceased
-
2002
- 2002-07-26 US US10/202,824 patent/US7112418B2/en not_active Expired - Fee Related
-
2005
- 2005-05-25 US US11/136,464 patent/US20050221394A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008517629A (ja) * | 2004-10-27 | 2008-05-29 | シェーリング コーポレイション | Nav1.8の短い干渉核酸阻害のための組成物および方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1281717A3 (en) | 2003-04-23 |
DE69626984D1 (de) | 2003-04-30 |
ATE235512T1 (de) | 2003-04-15 |
AU721798B2 (en) | 2000-07-13 |
US20050221394A1 (en) | 2005-10-06 |
US6451554B1 (en) | 2002-09-17 |
ES2196158T3 (es) | 2003-12-16 |
AU6234596A (en) | 1997-01-30 |
DK0835261T3 (da) | 2003-07-21 |
PT835261E (pt) | 2003-08-29 |
EP0835261B1 (en) | 2003-03-26 |
US20030176648A1 (en) | 2003-09-18 |
US7112418B2 (en) | 2006-09-26 |
EP0835261A1 (en) | 1998-04-15 |
DE69626984T2 (de) | 2003-12-18 |
CA2221294A1 (en) | 1997-01-16 |
WO1997001577A1 (en) | 1997-01-16 |
GB9513180D0 (en) | 1995-08-30 |
EP1281717A2 (en) | 2003-02-05 |
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