JPH11507541A - 低酸素誘導因子−１および使用方法 - Google Patents
低酸素誘導因子−１および使用方法Info
- Publication number
- JPH11507541A JPH11507541A JP9502264A JP50226497A JPH11507541A JP H11507541 A JPH11507541 A JP H11507541A JP 9502264 A JP9502264 A JP 9502264A JP 50226497 A JP50226497 A JP 50226497A JP H11507541 A JPH11507541 A JP H11507541A
- Authority
- JP
- Japan
- Prior art keywords
- hif
- sequence
- dna
- nucleotide sequence
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- Optical Communication System (AREA)
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- Electrophonic Musical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US08/480,473 US5882914A (en) | 1995-06-06 | 1995-06-06 | Nucleic acids encoding the hypoxia inducible factor-1 |
| PCT/US1996/010251 WO1996039426A1 (en) | 1995-06-06 | 1996-06-06 | Hypoxia inducible factor-1 and method of use |
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| JP2008284139A Division JP2009077729A (ja) | 1995-06-06 | 2008-11-05 | 低酸素誘導因子−１および使用方法 |
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| JP2008284139A Pending JP2009077729A (ja) | 1995-06-06 | 2008-11-05 | 低酸素誘導因子−１および使用方法 |
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| EP (2) | EP1806357A1 (enExample) |
| JP (2) | JPH11507541A (enExample) |
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| AU (1) | AU704384B2 (enExample) |
| CA (1) | CA2222279C (enExample) |
| DE (1) | DE69636936T2 (enExample) |
| IL (1) | IL118581A (enExample) |
| WO (1) | WO1996039426A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007512847A (ja) * | 2003-12-03 | 2007-05-24 | アネシヴァ， インコーポレイテッド | Ｈｉｆオリコヌクレオチドデコイ分子 |
| JP2009077729A (ja) * | 1995-06-06 | 2009-04-16 | Johns Hopkins Univ School Of Medicine | 低酸素誘導因子−１および使用方法 |
| JP2016514950A (ja) * | 2013-01-25 | 2016-05-26 | エックスセル・バイオサイエンシズ・インコーポレイテッド | 標的細胞の選択的富化のための方法、組成物、キット、及びシステム |
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| AU8536998A (en) * | 1997-06-10 | 1998-12-30 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Regulatory sequences involved in hypoxia regulated gene expression and uses thereof |
| US7973156B2 (en) | 1997-08-21 | 2011-07-05 | Quark Pharmaceuticals Inc. | Hypoxia-regulated genes |
| US7074895B2 (en) | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
| WO1999009046A1 (en) | 1997-08-21 | 1999-02-25 | Quark Biotech, Inc. | Hypoxia-regulated genes |
| AU757930B2 (en) | 1997-12-01 | 2003-03-13 | Roche Diagnostics Gmbh | Optimization of cells for endogenous gene activation |
| AU749467B2 (en) * | 1997-12-04 | 2002-06-27 | Genzyme Corporation | Compositions and methods for inducing gene expression |
| WO1999048916A2 (en) * | 1998-03-27 | 1999-09-30 | The Board Of Trustees Of The Leland Stanford Jr. University | Hypoxia-inducible human genes, proteins, and uses thereof |
| US6124131A (en) | 1998-08-25 | 2000-09-26 | The Johns Hopkins University School Of Medicine | Mutant hypoxia inducible factor-1 HIF-1 |
| CA2341518A1 (en) * | 1998-08-27 | 2000-03-09 | Quark Biotech, Inc. | Hypoxia regulated genes |
| US6436654B1 (en) * | 1998-11-13 | 2002-08-20 | Pharmacia & Upjohn Ab | Methods for identifying compounds that modulate HIF-1α |
| SE9803891D0 (sv) * | 1998-11-13 | 1998-11-13 | Pharmacia & Upjohn Ab | Protein Variants |
| JP4638098B2 (ja) * | 1999-06-14 | 2011-02-23 | キャンサー・リサーチ・テクノロジー・リミテッド | 癌治療 |
| WO2001023426A2 (en) * | 1999-09-30 | 2001-04-05 | Varian Associates, Inc. | Hypoxia-related human genes, proteins, and uses thereof |
| FR2801319A1 (fr) * | 1999-11-18 | 2001-05-25 | Inst Nat Sante Rech Med | Construction d'acide nucleique porteuse d'un systeme regulant l'expression d'un gene |
| US6893867B1 (en) | 1999-12-23 | 2005-05-17 | Keith A. Webster | Molecular switch for regulating mammalian gene expression |
| CN1425075A (zh) * | 2000-02-22 | 2003-06-18 | 牛津生物医学（英国）有限公司 | 差异表达筛选方法 |
| AU2001290179B2 (en) * | 2000-08-07 | 2007-07-12 | Angiogenetics Sweden Ab | Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein |
| US7285414B2 (en) * | 2000-09-26 | 2007-10-23 | Emory University | Viruses targeted to hypoxic cells and tissues |
| US20040101825A1 (en) * | 2001-09-26 | 2004-05-27 | Van Meir Erwin G. | Viruses targeted to hypoxic cells and tissues |
| US7105656B2 (en) * | 2000-10-26 | 2006-09-12 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating hematologic malignancies and multiple drug resistance |
| US7919274B2 (en) | 2001-03-20 | 2011-04-05 | Dana-Farber Cancer Institute, Inc. | Light-emitting fusion proteins and diagnostic and therapeutic methods therefor |
| US6849718B2 (en) * | 2001-03-20 | 2005-02-01 | Dana Farber Cancer Institute, Inc. | Muteins of hypoxia inducible factor alpha and methods of use thereof |
| US7176345B2 (en) * | 2001-03-20 | 2007-02-13 | Dana-Farber Cancer Institute, Inc. | Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor |
| US6855510B2 (en) | 2001-03-20 | 2005-02-15 | Dana Farber Cancer Institute, Inc. | Pharmaceuticals and methods for treating hypoxia and screening methods therefor |
| US6660737B2 (en) | 2001-05-04 | 2003-12-09 | The Procter & Gamble Company | Medicinal uses of hydrazones |
| US6878729B2 (en) | 2001-05-04 | 2005-04-12 | The Procter & Gamble Company | Medicinal uses of dihydropyrazoles |
| WO2002094862A2 (en) * | 2001-05-23 | 2002-11-28 | Angiogene Inc. | Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions |
| DE60232443D1 (de) * | 2001-06-05 | 2009-07-09 | Masahiro Hiraoka | Polypeptid-destabiliserendes protein in zellen unter aeroben bedingungen und dieses codierende dna |
| US6838430B2 (en) | 2001-09-28 | 2005-01-04 | The Regents Of The University Of California | Use of HIF-1a variants to accelerate wound healing |
| FR2832154B1 (fr) | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
| AU2003208684A1 (en) * | 2002-03-05 | 2003-09-16 | Angiogenetics Sweden Ab | Critical hypoxia-inducible factor-1alpha residues, products and methods related thereto |
| ES2649817T3 (es) * | 2002-04-05 | 2018-01-15 | Roche Innovation Center Copenhagen A/S | Compuestos oligom¿¿ricos para la modulaci¿®n de la expresi¿®n de HIF-1¿Á |
| CA2482904A1 (en) * | 2002-04-18 | 2003-10-23 | Lynkeus Biotech Gmbh | Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification |
| NZ520321A (en) * | 2002-07-19 | 2005-03-24 | Auckland Uniservices Ltd | Use of an agent adapted to inhibit HIF in use together with an antiangiogenic agent for treating tumours in a non- human animal |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| KR20120038546A (ko) * | 2002-11-01 | 2012-04-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | ＨＩＦ-1 알파의 ｓｉＲＮＡ 억제를 위한 조성물 및 방법 |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| US20050014264A1 (en) * | 2002-12-11 | 2005-01-20 | University Of Massachusetts | Method of introducing siRNA into adipocytes |
| WO2004066949A2 (en) | 2003-01-28 | 2004-08-12 | Rexahn Corporation | Antisense oligonucleotides that inhibit expression of hif-1 |
| ES2333794T3 (es) * | 2003-01-31 | 2010-03-01 | Rexahn Pharmaceuticals, Inc. | Oligonucleotidos que inhiben la expresion de hif-1. |
| JP2007512369A (ja) * | 2003-11-26 | 2007-05-17 | エンテロス・インコーポレーテッド | 低酸素誘導因子１αアンタゴニストを用いる慢性関節リウマチの処置 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2059131A1 (en) * | 1989-06-23 | 1990-12-24 | Ming-Shi Chang | Compositions and methods for the synthesis of natriuretic protein receptor b and methods of use |
| US5882914A (en) * | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
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- 1995-06-06 US US08/480,473 patent/US5882914A/en not_active Expired - Lifetime
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- 1996-06-05 IL IL11858196A patent/IL118581A/xx not_active IP Right Cessation
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- 1996-06-06 EP EP07000451A patent/EP1806357A1/en not_active Withdrawn
- 1996-06-06 EP EP96922458A patent/EP0833840B1/en not_active Expired - Lifetime
- 1996-06-06 AU AU63326/96A patent/AU704384B2/en not_active Ceased
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- 1996-06-06 AT AT96922458T patent/ATE355299T1/de not_active IP Right Cessation
- 1996-06-06 JP JP9502264A patent/JPH11507541A/ja active Pending
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- 1997-08-20 US US08/915,213 patent/US6020462A/en not_active Expired - Lifetime
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- 1999-01-22 US US09/235,217 patent/US6222018B1/en not_active Expired - Lifetime
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009077729A (ja) * | 1995-06-06 | 2009-04-16 | Johns Hopkins Univ School Of Medicine | 低酸素誘導因子−１および使用方法 |
| JP2007512847A (ja) * | 2003-12-03 | 2007-05-24 | アネシヴァ， インコーポレイテッド | Ｈｉｆオリコヌクレオチドデコイ分子 |
| JP2016514950A (ja) * | 2013-01-25 | 2016-05-26 | エックスセル・バイオサイエンシズ・インコーポレイテッド | 標的細胞の選択的富化のための方法、組成物、キット、及びシステム |
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| EP0833840B1 (en) | 2007-02-28 |
| WO1996039426A1 (en) | 1996-12-12 |
| IL118581A0 (en) | 1996-10-16 |
| CA2222279A1 (en) | 1996-12-12 |
| AU704384B2 (en) | 1999-04-22 |
| US5882914A (en) | 1999-03-16 |
| EP0833840A1 (en) | 1998-04-08 |
| EP0833840A4 (en) | 2001-12-19 |
| JP2009077729A (ja) | 2009-04-16 |
| AU6332696A (en) | 1996-12-24 |
| US6020462A (en) | 2000-02-01 |
| IL118581A (en) | 2000-01-31 |
| EP1806357A1 (en) | 2007-07-11 |
| CA2222279C (en) | 2011-02-01 |
| ATE355299T1 (de) | 2006-03-15 |
| DE69636936D1 (de) | 2007-04-12 |
| DE69636936T2 (de) | 2007-10-31 |
| US6222018B1 (en) | 2001-04-24 |
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