CA2222279C - Hypoxia inducible factor-1 and method of use - Google Patents
Hypoxia inducible factor-1 and method of use Download PDFInfo
- Publication number
- CA2222279C CA2222279C CA2222279A CA2222279A CA2222279C CA 2222279 C CA2222279 C CA 2222279C CA 2222279 A CA2222279 A CA 2222279A CA 2222279 A CA2222279 A CA 2222279A CA 2222279 C CA2222279 C CA 2222279C
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- hif
- alpha
- hypoxia
- seq
- polypeptide
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Optical Communication System (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrophonic Musical Instruments (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/480,473 | 1995-06-06 | ||
| US08/480,473 US5882914A (en) | 1995-06-06 | 1995-06-06 | Nucleic acids encoding the hypoxia inducible factor-1 |
| PCT/US1996/010251 WO1996039426A1 (en) | 1995-06-06 | 1996-06-06 | Hypoxia inducible factor-1 and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2222279A1 CA2222279A1 (en) | 1996-12-12 |
| CA2222279C true CA2222279C (en) | 2011-02-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2222279A Expired - Lifetime CA2222279C (en) | 1995-06-06 | 1996-06-06 | Hypoxia inducible factor-1 and method of use |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5882914A (enExample) |
| EP (2) | EP1806357A1 (enExample) |
| JP (2) | JPH11507541A (enExample) |
| AT (1) | ATE355299T1 (enExample) |
| AU (1) | AU704384B2 (enExample) |
| CA (1) | CA2222279C (enExample) |
| DE (1) | DE69636936T2 (enExample) |
| IL (1) | IL118581A (enExample) |
| WO (1) | WO1996039426A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882914A (en) * | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
| AU8536998A (en) * | 1997-06-10 | 1998-12-30 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Regulatory sequences involved in hypoxia regulated gene expression and uses thereof |
| US7973156B2 (en) | 1997-08-21 | 2011-07-05 | Quark Pharmaceuticals Inc. | Hypoxia-regulated genes |
| US7074895B2 (en) | 1997-08-21 | 2006-07-11 | Quark Biotech, Inc. | Sequences characteristic of hypoxia-regulated gene transcription |
| WO1999009046A1 (en) | 1997-08-21 | 1999-02-25 | Quark Biotech, Inc. | Hypoxia-regulated genes |
| AU757930B2 (en) | 1997-12-01 | 2003-03-13 | Roche Diagnostics Gmbh | Optimization of cells for endogenous gene activation |
| AU749467B2 (en) * | 1997-12-04 | 2002-06-27 | Genzyme Corporation | Compositions and methods for inducing gene expression |
| WO1999048916A2 (en) * | 1998-03-27 | 1999-09-30 | The Board Of Trustees Of The Leland Stanford Jr. University | Hypoxia-inducible human genes, proteins, and uses thereof |
| US6124131A (en) | 1998-08-25 | 2000-09-26 | The Johns Hopkins University School Of Medicine | Mutant hypoxia inducible factor-1 HIF-1 |
| CA2341518A1 (en) * | 1998-08-27 | 2000-03-09 | Quark Biotech, Inc. | Hypoxia regulated genes |
| US6436654B1 (en) * | 1998-11-13 | 2002-08-20 | Pharmacia & Upjohn Ab | Methods for identifying compounds that modulate HIF-1α |
| SE9803891D0 (sv) * | 1998-11-13 | 1998-11-13 | Pharmacia & Upjohn Ab | Protein Variants |
| JP4638098B2 (ja) * | 1999-06-14 | 2011-02-23 | キャンサー・リサーチ・テクノロジー・リミテッド | 癌治療 |
| WO2001023426A2 (en) * | 1999-09-30 | 2001-04-05 | Varian Associates, Inc. | Hypoxia-related human genes, proteins, and uses thereof |
| FR2801319A1 (fr) * | 1999-11-18 | 2001-05-25 | Inst Nat Sante Rech Med | Construction d'acide nucleique porteuse d'un systeme regulant l'expression d'un gene |
| US6893867B1 (en) | 1999-12-23 | 2005-05-17 | Keith A. Webster | Molecular switch for regulating mammalian gene expression |
| CN1425075A (zh) * | 2000-02-22 | 2003-06-18 | 牛津生物医学（英国）有限公司 | 差异表达筛选方法 |
| AU2001290179B2 (en) * | 2000-08-07 | 2007-07-12 | Angiogenetics Sweden Ab | Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein |
| US7285414B2 (en) * | 2000-09-26 | 2007-10-23 | Emory University | Viruses targeted to hypoxic cells and tissues |
| US20040101825A1 (en) * | 2001-09-26 | 2004-05-27 | Van Meir Erwin G. | Viruses targeted to hypoxic cells and tissues |
| US7105656B2 (en) * | 2000-10-26 | 2006-09-12 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating hematologic malignancies and multiple drug resistance |
| US7919274B2 (en) | 2001-03-20 | 2011-04-05 | Dana-Farber Cancer Institute, Inc. | Light-emitting fusion proteins and diagnostic and therapeutic methods therefor |
| US6849718B2 (en) * | 2001-03-20 | 2005-02-01 | Dana Farber Cancer Institute, Inc. | Muteins of hypoxia inducible factor alpha and methods of use thereof |
| US7176345B2 (en) * | 2001-03-20 | 2007-02-13 | Dana-Farber Cancer Institute, Inc. | Transgenic animals expressing light-emitting fusion proteins and diagnostic and therapeutic methods therefor |
| US6855510B2 (en) | 2001-03-20 | 2005-02-15 | Dana Farber Cancer Institute, Inc. | Pharmaceuticals and methods for treating hypoxia and screening methods therefor |
| US6660737B2 (en) | 2001-05-04 | 2003-12-09 | The Procter & Gamble Company | Medicinal uses of hydrazones |
| US6878729B2 (en) | 2001-05-04 | 2005-04-12 | The Procter & Gamble Company | Medicinal uses of dihydropyrazoles |
| WO2002094862A2 (en) * | 2001-05-23 | 2002-11-28 | Angiogene Inc. | Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions |
| DE60232443D1 (de) * | 2001-06-05 | 2009-07-09 | Masahiro Hiraoka | Polypeptid-destabiliserendes protein in zellen unter aeroben bedingungen und dieses codierende dna |
| US6838430B2 (en) | 2001-09-28 | 2005-01-04 | The Regents Of The University Of California | Use of HIF-1a variants to accelerate wound healing |
| FR2832154B1 (fr) | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
| AU2003208684A1 (en) * | 2002-03-05 | 2003-09-16 | Angiogenetics Sweden Ab | Critical hypoxia-inducible factor-1alpha residues, products and methods related thereto |
| ES2649817T3 (es) * | 2002-04-05 | 2018-01-15 | Roche Innovation Center Copenhagen A/S | Compuestos oligom¿¿ricos para la modulaci¿®n de la expresi¿®n de HIF-1¿Á |
| CA2482904A1 (en) * | 2002-04-18 | 2003-10-23 | Lynkeus Biotech Gmbh | Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification |
| NZ520321A (en) * | 2002-07-19 | 2005-03-24 | Auckland Uniservices Ltd | Use of an agent adapted to inhibit HIF in use together with an antiangiogenic agent for treating tumours in a non- human animal |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| KR20120038546A (ko) * | 2002-11-01 | 2012-04-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | ＨＩＦ-1 알파의 ｓｉＲＮＡ 억제를 위한 조성물 및 방법 |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| US20050014264A1 (en) * | 2002-12-11 | 2005-01-20 | University Of Massachusetts | Method of introducing siRNA into adipocytes |
| WO2004066949A2 (en) | 2003-01-28 | 2004-08-12 | Rexahn Corporation | Antisense oligonucleotides that inhibit expression of hif-1 |
| ES2333794T3 (es) * | 2003-01-31 | 2010-03-01 | Rexahn Pharmaceuticals, Inc. | Oligonucleotidos que inhiben la expresion de hif-1. |
| JP2007512369A (ja) * | 2003-11-26 | 2007-05-17 | エンテロス・インコーポレーテッド | 低酸素誘導因子１αアンタゴニストを用いる慢性関節リウマチの処置 |
| WO2005056795A2 (en) * | 2003-12-03 | 2005-06-23 | Corgentech, Inc. | Hif oligonucleotide decoy molecules |
| US20060003961A1 (en) * | 2004-06-18 | 2006-01-05 | The John Hopkins University | Negative regulation of hypoxia inducible factor 1 by OS-9 |
| NZ555644A (en) | 2004-11-09 | 2009-04-30 | Santaris Pharma As | Potent LNA oligonucleotides for the inhibition of HIF-1A expression |
| US9447138B2 (en) | 2004-11-09 | 2016-09-20 | Roche Innovation Center Copenhagen A/S | Potent LNA oligonucleotides for the inhibition of HIF-1a expression |
| KR100859506B1 (ko) * | 2005-07-22 | 2008-09-22 | 한국과학기술연구원 | 프롤린 수산화반응에 의한 ｈｉｆ―1 펩타이드와 ｖｂｃ단백질과의 상호작용을 형광편광도를 이용하여 정량적으로분석하는 방법 |
| CN100418574C (zh) * | 2005-10-26 | 2008-09-17 | 王成球 | 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽 |
| US20070122448A1 (en) * | 2005-11-28 | 2007-05-31 | Alireza Rezania | Compositions and methods to create a vascularized environment for cellular transplantation |
| ES2596885T3 (es) | 2006-06-07 | 2017-01-12 | Genzyme Corporation | Terapia génica para esclerosis lateral amiotrófica y otros trastornos de la medula espinal |
| JP2009540011A (ja) * | 2006-06-12 | 2009-11-19 | エクセジェニックス、インク．ディー／ビー／エー オプコ ヘルス、インク． | 血管新生のｓｉＲＮＡ阻害のための組成物及び方法 |
| US20080119433A1 (en) * | 2006-07-06 | 2008-05-22 | Aaron Thomas Tabor | Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance |
| US7872118B2 (en) * | 2006-09-08 | 2011-01-18 | Opko Ophthalmics, Llc | siRNA and methods of manufacture |
| SI2497500T1 (sl) | 2006-10-03 | 2017-01-31 | Genzyme Corporation | Genska terapija za spinalno mišično atrofijo |
| NZ598092A (en) * | 2008-02-14 | 2012-07-27 | Lincoln University | Methods and compositions comprising specific strains of trichoderma atroviride for the biological control of soil borne plant pathogens and promoting plant growth |
| MX2011005851A (es) | 2008-12-04 | 2011-07-29 | Opko Opthalmics Llc | Composiciones y metodos para la inhibicion selectiva de isoformas vegf proangiogenicas. |
| RS67077B1 (sr) | 2009-05-02 | 2025-08-29 | Genzyme Corp | Genska terapija za neurodegenerativne poremećaje |
| EP4219708A3 (en) | 2009-07-17 | 2023-10-11 | Aaron Thomas Tabor | Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance |
| WO2011109427A2 (en) | 2010-03-01 | 2011-09-09 | Alnylam Pharmaceuticals, Inc. | Improving the biological activity of sirna through modulation of its thermodynamic profile |
| US9446031B2 (en) | 2012-01-18 | 2016-09-20 | National University Of Singapore | Compositions and methods for neovascularization |
| CA2895791A1 (en) * | 2013-01-25 | 2014-07-31 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| JP6836400B2 (ja) | 2014-03-28 | 2021-03-03 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション | 乳がんおよび卵巣がんワクチン |
| GB201601527D0 (en) | 2016-01-27 | 2016-03-09 | Univ Southampton | Hif-1 and Hif-2 inhibitors |
| US20230212296A1 (en) * | 2020-06-02 | 2023-07-06 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for treating cancer |
| CN116024263A (zh) * | 2022-09-23 | 2023-04-28 | 龙岩学院 | 一种高效表达猪HIF-1α基因的真核表达载体及其构建方法 |
| WO2024211763A1 (en) * | 2023-04-05 | 2024-10-10 | The Johns Hopkins University | Synthetic mrna encoding hif-1alpha and uses for wound healing |
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| CA2059131A1 (en) * | 1989-06-23 | 1990-12-24 | Ming-Shi Chang | Compositions and methods for the synthesis of natriuretic protein receptor b and methods of use |
| US5882914A (en) * | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
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1995
- 1995-06-06 US US08/480,473 patent/US5882914A/en not_active Expired - Lifetime
-
1996
- 1996-06-05 IL IL11858196A patent/IL118581A/xx not_active IP Right Cessation
- 1996-06-06 WO PCT/US1996/010251 patent/WO1996039426A1/en not_active Ceased
- 1996-06-06 EP EP07000451A patent/EP1806357A1/en not_active Withdrawn
- 1996-06-06 EP EP96922458A patent/EP0833840B1/en not_active Expired - Lifetime
- 1996-06-06 AU AU63326/96A patent/AU704384B2/en not_active Ceased
- 1996-06-06 CA CA2222279A patent/CA2222279C/en not_active Expired - Lifetime
- 1996-06-06 AT AT96922458T patent/ATE355299T1/de not_active IP Right Cessation
- 1996-06-06 JP JP9502264A patent/JPH11507541A/ja active Pending
- 1996-06-06 DE DE69636936T patent/DE69636936T2/de not_active Expired - Lifetime
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1997
- 1997-08-20 US US08/915,213 patent/US6020462A/en not_active Expired - Lifetime
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1999
- 1999-01-22 US US09/235,217 patent/US6222018B1/en not_active Expired - Lifetime
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2008
- 2008-11-05 JP JP2008284139A patent/JP2009077729A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0833840B1 (en) | 2007-02-28 |
| WO1996039426A1 (en) | 1996-12-12 |
| IL118581A0 (en) | 1996-10-16 |
| CA2222279A1 (en) | 1996-12-12 |
| AU704384B2 (en) | 1999-04-22 |
| JPH11507541A (ja) | 1999-07-06 |
| US5882914A (en) | 1999-03-16 |
| EP0833840A1 (en) | 1998-04-08 |
| EP0833840A4 (en) | 2001-12-19 |
| JP2009077729A (ja) | 2009-04-16 |
| AU6332696A (en) | 1996-12-24 |
| US6020462A (en) | 2000-02-01 |
| IL118581A (en) | 2000-01-31 |
| EP1806357A1 (en) | 2007-07-11 |
| ATE355299T1 (de) | 2006-03-15 |
| DE69636936D1 (de) | 2007-04-12 |
| DE69636936T2 (de) | 2007-10-31 |
| US6222018B1 (en) | 2001-04-24 |
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