JPH11506931A - 腫瘍または細胞特異的な単純ヘルペスウイルスの複製 - Google Patents
腫瘍または細胞特異的な単純ヘルペスウイルスの複製Info
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- JPH11506931A JPH11506931A JP9501157A JP50115797A JPH11506931A JP H11506931 A JPH11506931 A JP H11506931A JP 9501157 A JP9501157 A JP 9501157A JP 50115797 A JP50115797 A JP 50115797A JP H11506931 A JPH11506931 A JP H11506931A
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- cells
- herpes simplex
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- simplex virus
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.必須の単純ヘルペスウイルス遺伝子に機能的に結合した腫瘍特異的または 組織特異的または細胞特異的なプロモーターを含む、複製可能な単純ヘルペスウ イルス。 2.ウイルスベクターのゲノムが、必須の単純ヘルペスウイルス遺伝子に機能 的に結合した腫瘍特異的または組織特異的または細胞特異的なプロモーターを含 む、単純ヘルペスウイルスベクター。 3.(A)必須の単純ヘルペスウイルス遺伝子に機能的に結合した腫瘍特異的な プロモーターを含む単純ヘルペスウイルスベクターと (B)該ベクターのための薬学的に許容される賦形剤とを含む薬学的組成物を、 腫瘍細胞が該ベクターによりインサイチューで改変され、それにより該腫瘍細胞 が死滅するよう、 患者に投与する段階を含む、患者において腫瘍細胞を死滅させるための方法。 4.腫瘍細胞が、黒色腫細胞、膵臓癌細胞、前立腺癌腫細胞、乳癌細胞、肺癌 細胞、結腸癌細胞、リンパ腫細胞、肝癌細胞、中皮腫および類表皮癌腫細胞から なる群より選択される種類のものである、請求項3記載の方法。 5.以下の段階を含む、単純ヘルペスウイルスの複製可能なベクターを調製す る方法: (A)該単純ヘルペスウイルスのウイルスゲノムを単離する段階、および (B)ウイルスが、(1)腫瘍細胞を死滅させ、(2)正常細胞に対する一般的な毒性を 欠き、(3)必須の単純ヘルペスウイルス遺伝子に機能的に結合した腫瘍特異的プ ロモーターを含むよう、該ゲノムを永続的に改変する段階。 6.ベクターの単純ヘルペスウイルスがHSV−1である、請求項5記載の方法。 7.ベクターの単純ヘルペスウイルスがHSV−2である、請求項5記載の方法。 8.(A)必須の単純ヘルペスウイルス遺伝子に機能的に結合した組織特異的ま たは腫瘍特異的または細胞特異的なプロモーターを含む単純ヘルペスウイルスベ クターと、 (B)該ベクターのための薬学的に許容される賦形剤とを含む薬学的組成物を、 特定の正常細胞が該ベクターによりインサイチューで改変され、それにより該細 胞が死滅するよう、患者に投与する段階を含む、患者において特定の正常細胞を 排除する方法。 9.正常細胞が下垂体細胞であり、細胞特異的プロモーターが成長ホルモンプ ロモーターである、請求項8記載の方法。 10.正常細胞が副腎皮質細胞であり、該細胞特異的プロモーターがプロオピ オメラノコルチンである、請求項8記載の方法。 11.ウイルス複製に必要な少なくとも1つのウイルス蛋白質の発現を制御し 、かつ選択的にまたは正常細胞よりも高いレベルで腫瘍細胞において誘導される 腫瘍細胞特異的プロモーターを有する単純ヘルペスウイルスベクターを患者に投 与する段階を含む、患者において腫瘍細胞を死滅させる方法。 12.必須単純ヘルペスウイルス遺伝子がHSVのごく初期の遺伝子である、請 求項1記載の複製可能な単純ヘルペスウイルス。 13.HSVの極く初期の遺伝子がICP4遺伝子である、請求項12記載の複製可 能な単純ヘルペスウイルス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/486,147 US5728379A (en) | 1994-06-23 | 1995-06-07 | Tumor- or cell-specific herpes simplex virus replication |
US08/486,147 | 1995-06-07 | ||
PCT/US1996/008621 WO1996039841A1 (en) | 1995-06-07 | 1996-06-06 | Tumor- or cell-specific herpes simplex virus replication |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11506931A true JPH11506931A (ja) | 1999-06-22 |
JP3865319B2 JP3865319B2 (ja) | 2007-01-10 |
Family
ID=23930788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP50115797A Expired - Fee Related JP3865319B2 (ja) | 1995-06-07 | 1996-06-06 | 腫瘍または細胞特異的な単純ヘルペスウイルスの複製 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5728379A (ja) |
EP (1) | EP0839054B1 (ja) |
JP (1) | JP3865319B2 (ja) |
AT (1) | ATE274593T1 (ja) |
AU (1) | AU699811B2 (ja) |
CA (1) | CA2223691C (ja) |
DE (1) | DE69633236T2 (ja) |
ES (1) | ES2227593T3 (ja) |
WO (1) | WO1996039841A1 (ja) |
Cited By (1)
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2022541464A (ja) * | 2019-07-16 | 2022-09-26 | 伍沢堂 | 腫瘍溶解性ウイルス、その使用、およびがんを治療する医薬品 |
Also Published As
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EP0839054B1 (en) | 2004-08-25 |
AU699811B2 (en) | 1998-12-17 |
JP3865319B2 (ja) | 2007-01-10 |
WO1996039841A1 (en) | 1996-12-19 |
CA2223691A1 (en) | 1996-12-19 |
DE69633236D1 (de) | 2004-09-30 |
DE69633236T2 (de) | 2005-09-15 |
EP0839054A1 (en) | 1998-05-06 |
ES2227593T3 (es) | 2005-04-01 |
ATE274593T1 (de) | 2004-09-15 |
EP0839054A4 (en) | 2002-04-17 |
US5728379A (en) | 1998-03-17 |
CA2223691C (en) | 2009-08-18 |
AU6149596A (en) | 1996-12-30 |
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