JPH11504026A - ウイルス性疾患治療用医薬の製造のための(r)−ペンシクロビルトリホスフェートの使用 - Google Patents
ウイルス性疾患治療用医薬の製造のための(r)−ペンシクロビルトリホスフェートの使用Info
- Publication number
- JPH11504026A JPH11504026A JP8532161A JP53216196A JPH11504026A JP H11504026 A JPH11504026 A JP H11504026A JP 8532161 A JP8532161 A JP 8532161A JP 53216196 A JP53216196 A JP 53216196A JP H11504026 A JPH11504026 A JP H11504026A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pcv
- added
- triphosphate
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.i)ヒトを包含する哺乳動物におけるHIV−1感染;または ii)ヒトを包含する哺乳動物におけるHBV感染 の治療方法をであって、かかる治療を必要とするヒトに有効量の式(A)の化合 物: のトリホスフェートの(R)−エナンチオマーまたはその医薬上許容される塩を 投与することを特徴とする方法。 2.HIV−1感染またはHBV感染の治療用の医薬の製造における式(A) の化合物: のトリホスフェートの(R)−エナンチオマーまたはその医薬上許容される塩の 使用。 3.式(A)の化合物: のトリホスフェートの(R)−エナンチオマーまたはその医薬上許容される塩; および医薬上許容される担体を含んでなる、HIV感染またはHBV感染の治療 用の医薬組成物。 4.(R)−PCV−TPが、細胞内で(R)−PCV−MP(後に(R)− PCV−TPに変換される)を遊離する(R)−PCV−MPの誘導体である生 物学的前駆体の形態である、請求項1、2または3に記載の方法、組成物または 使用。 5.請求項1、2、3または4に記載の方法、組成物または使用において用い られる(R)−PCV−TPの生物学的前駆体である化合物。 6.(R)−PCV−MPの誘導体である(R)−PCV−TPの生物学的前 駆体である化合物。 7.PL−ASOR誘導体; リン脂質誘導体; (R)−MP Bis(POM)誘導体; (R)−MPジフェニルエステル誘導体; ジミリストイルグリセロールジホスフェート誘導体 から選択される請求項6記載の化合物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9508237.6A GB9508237D0 (en) | 1995-04-24 | 1995-04-24 | Pharmaceuticals |
GB9508237.6 | 1995-04-24 | ||
GB9604909.3 | 1996-03-08 | ||
GBGB9604909.3A GB9604909D0 (en) | 1996-03-08 | 1996-03-08 | Pharmaceuticals |
PCT/EP1996/001706 WO1996033720A1 (en) | 1995-04-24 | 1996-04-23 | Use of (r)-penciclovir triphosphate for the manufacture of a medicament for the treatment of viral diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11504026A true JPH11504026A (ja) | 1999-04-06 |
Family
ID=26306919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8532161A Pending JPH11504026A (ja) | 1995-04-24 | 1996-04-23 | ウイルス性疾患治療用医薬の製造のための(r)−ペンシクロビルトリホスフェートの使用 |
Country Status (6)
Country | Link |
---|---|
US (4) | US7045525B1 (ja) |
EP (1) | EP0822817B1 (ja) |
JP (1) | JPH11504026A (ja) |
DE (1) | DE69629188T2 (ja) |
ES (1) | ES2203692T3 (ja) |
WO (1) | WO1996033720A1 (ja) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4845084A (en) * | 1984-01-26 | 1989-07-04 | Merck & Co., Inc. | Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them |
GB8904855D0 (en) * | 1989-03-03 | 1989-04-12 | Beecham Group Plc | Pharmaceutical treatment |
GB9015051D0 (en) * | 1990-07-07 | 1990-08-29 | Beecham Group Plc | Pharmaceutical treatment |
-
1996
- 1996-04-23 WO PCT/EP1996/001706 patent/WO1996033720A1/en active IP Right Grant
- 1996-04-23 EP EP96914109A patent/EP0822817B1/en not_active Expired - Lifetime
- 1996-04-23 US US08/945,249 patent/US7045525B1/en not_active Expired - Fee Related
- 1996-04-23 ES ES96914109T patent/ES2203692T3/es not_active Expired - Lifetime
- 1996-04-23 DE DE69629188T patent/DE69629188T2/de not_active Expired - Lifetime
- 1996-04-23 JP JP8532161A patent/JPH11504026A/ja active Pending
-
2005
- 2005-12-13 US US11/231,115 patent/US20060069108A1/en not_active Abandoned
-
2010
- 2010-12-22 US US12/976,599 patent/US20110092458A1/en not_active Abandoned
-
2013
- 2013-06-19 US US13/921,233 patent/US20130281470A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69629188T2 (de) | 2004-04-22 |
US20110092458A1 (en) | 2011-04-21 |
WO1996033720A1 (en) | 1996-10-31 |
US7045525B1 (en) | 2006-05-16 |
EP0822817B1 (en) | 2003-07-23 |
US20060069108A1 (en) | 2006-03-30 |
DE69629188D1 (de) | 2003-08-28 |
ES2203692T3 (es) | 2004-04-16 |
EP0822817A1 (en) | 1998-02-11 |
US20130281470A1 (en) | 2013-10-24 |
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