JPH10510181A - 可調節型の椎骨体代替物 - Google Patents
可調節型の椎骨体代替物Info
- Publication number
- JPH10510181A JPH10510181A JP8517672A JP51767296A JPH10510181A JP H10510181 A JPH10510181 A JP H10510181A JP 8517672 A JP8517672 A JP 8517672A JP 51767296 A JP51767296 A JP 51767296A JP H10510181 A JPH10510181 A JP H10510181A
- Authority
- JP
- Japan
- Prior art keywords
- implant
- vertebral
- vertebral replacement
- replacement implant
- cylindrical portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30744—End caps, e.g. for closing an endoprosthetic cavity
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7059—Cortical plates
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8061—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates specially adapted for particular bones
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/02—Surgical instruments, devices or methods, e.g. tourniquets for holding wounds open; Tractors
- A61B17/025—Joint distractors
- A61B2017/0256—Joint distractors for the spine
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/3011—Cross-sections or two-dimensional shapes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
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- A61F2002/30108—Shapes
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- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30537—Special structural features of bone or joint prostheses not otherwise provided for adjustable
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.隣接する完全な椎骨の間にて1つ又はより多くの除去した椎骨により形成 されたスペース内に介在される椎骨代替用インプラントにして、 完全な椎骨の間のスペースの一部を跨ぐ寸法とされた、両端を有する代替物体 であって、該両端の各々に形成された第一のねじを有する前記代替物体と、 前記スペース内に前記インプラントを介在させたとき、前記完全な椎骨のそれ ぞれの1つと接触する端面を有する一対の端板を備え、該端板の各々が該端面か ら一体に伸長する円筒状部分を有し、該円筒状部分が、前記代替物体上の第一の ねじと螺着可能に係合する形態とされた第二のねじを有し、前記端板の各々が、 前記端面に及び前記円筒状部分に開口する貫通穴を更に画成する、椎骨代替用イ ンプラント。 2.請求項1に記載の椎骨代替用インプラントにして、前記代替物体が中空の 内部を画成する円筒壁を有し、該円筒壁が貫通する複数の穴を画成し、該穴が、 前記代替物体の前記中空の内部と連通し、前記代替物体内への組織の内部成長を 促進する、椎骨代替用インプラント。 3.請求項2に記載の椎骨代替物体にして、前記代替物体を画成する前記円筒 壁が、ある表面積を有し、該複数の穴が、該表面積の25%以上の有効面積を画成 する、椎骨代替物体。 4.請求項2に記載の椎骨代替用インプラントにして、前記代替物体の前記中 空の内部が前記両端にて開口している、椎骨代替用インプラント。 5.請求項1に記載の椎骨代替用インプラントにして、前記代替物体が中空の 内部を画成する円筒壁を有し、前記両端にて開口している、椎骨代替用インプラ ント。 6.請求項5に記載の椎骨代替用インプラントにして、前記端板の各々が前記 端面に及び前記円筒状部分にて開口する貫通穴を画成する、椎骨代替用インプラ ント。 7.請求項6に記載の椎骨代替用インプラントにして、前記代替物体上の前記 第一のねじが雄ねじであり、前記対の端板の前記円筒状部分上の前記第二のねじ が雌ねじである、椎骨代替用インプラント。 8.請求項1に記載の椎骨代替用インプラントにして、その前記端面にて前記 端板の1つの前記穴を閉じる端部キャップを更に備え、該端部キャップが、該端 部キャップを前記端板の上に支持する手段を有する、椎骨代替用インプラント。 9.請求項1に記載の椎骨代替用インプラントにして、前記代替物体上の前記 第一のねじが雄ねじであり、前記対の端板の前記円筒状部分上の前記第二のねじ が雌ねじである、椎骨代替用インプラント。 10.請求項1に記載の椎骨代替用インプラントにして、前記代替物体を前記端 板の各々に対して固定し、前記第一及び第二のねじの緩みを防止する手段を更に 備える、椎骨代替用インプラント。 11.請求項10に記載の椎骨代替用インプラントにして、前記固定手段が、 前記対の端板の各々の前記円筒状部分に画成された多数の開口部と、 該多数の穴の1つを貫通して伸長し、前記代替物体と接触可能な部材とを備え る、椎骨代替用インプラント。 12.請求項11に記載の椎骨代替用インプラントにして、 前記部材が止めねじであり、 前記多数の開口部には、前記止めねじを螺着係合状態に受け入れ得るようにね じが形成される、椎骨代替用インプラント。 13.請求項11に記載の椎骨代替用インプラントにして、前記多数の開口部が 前記第二のねじにて前記端板に画成される、椎骨代替用インプラント。 14.請求項1に記載の椎骨代替用インプラントにして、前記端板の各々が前記 端面を画成するフランジを備え、該フランジが前記円筒状部分から半径方向外方 に伸長し、該フランジが、前記端板が接触している前記完全な椎骨の一部分の形 状に略対応する形状を画成する、椎骨代替用インプラント。 15.請求項14に記載の椎骨代替用インプラントにして、前記フランジが、貫 通する導管化穴を多数画成する、椎骨代替用インプラント。 16.請求項15に記載の椎骨代替用インプラントにして、 前記端部キャップが、 前記端板に形成された前記穴開口部に対応する形状とされたプレートと、 前記端板と、 該端板に取り付けられた支持バーとを備え、 前記端板が、前記支持バーを受け入れ得るように前記端面に画成されたスロッ トを有し、前記端部キャップの前記プレートが前記端板の前記端面と平らに位置 するようにした、椎骨代替用インプラント。 17.請求項10に記載の椎骨代替用インプラントにして、 前記端板の各々の前記円筒状部分が前記端面から突き出す長さを有し、 前記固定手段が、前記円筒状部分の前記長さの一部に沿って形成された圧着切 欠きを備え、 前記円筒状部分が、前記圧着切欠きにて変形し、前記切欠きを閉じ、これによ り、前記代替物体が前記端板の円筒状部分に螺着可能に係合したとき、該代替物 体の周りの前記円筒状部分の外周が縮小するようにした、椎骨代替用インプラン ト。 18.請求項1に記載の椎骨代替用インプラントにして、前記対の端板の各々が 前記隣接する完全な椎骨の対応する1つに植え込むべく前記端面から突き出す多 数のスパイクを備える、椎骨代替用インプラント。 19.請求項18に記載の椎骨代替用インプラントにして、 前記対の端板の各々の前記端面が多数のねじ付き穴を画成し、 前記多数のスパイクの各々が、前記端板の各々の前記端面における前記ねじ付 き穴と係合し得る形態とされたねじ付きポストを備える、椎骨代替用インプラン ト。 20.請求項1に記載の椎骨代替用インプラントにして、前記端板の各々の前記 円筒状部分が垂直でない角度にて前記端面から伸長し、該角度が、前記除去した 椎骨により形成されるスペースにおける脊柱の曲率に対応する、椎骨代替用イン プラント。 21.請求項1に記載の椎骨代替用インプラントにして、前記端板の各々が、前 記端面を画成し且つ前記円筒状部分から外方に伸長するフランジを備え、 該フランジが、前記円筒状部分から突き出すアームを備え、 該アームが、前記脊柱の長さに沿って配置された長手方向部材に係合すべく前 記隣接する完全な椎骨を超えて伸長する形態とされた自由端を有する、椎骨代替 用インプラント。 22.請求項21に記載の椎骨代替用インプラントにして、前記アームが、前記 長手方向部材を受け入れるべく前記自由端に穴を画成する、椎骨代替用インプラ ント。 23.損傷した中間の椎骨を除去した後、隣接する完全な椎骨を固定する組立体 にして、 椎骨代替用インプラントを備え、該インプラントが、 該損傷した椎骨の除去により形成されるスペースの一部を跨ぐ寸法とされた、 両端を有する代替物体であって、第一のねじが形成された前記代替物体と、 前記インプラントが前記スペース内に介在されたとき、前記完全な椎骨のそれ ぞれの1つに接触する端面を有する一対の端板とを備え、 該端板の各々が、前記端面から一体に伸長する円筒状部分を有し、 該円筒状部分が、前記代替物体上のねじと螺着可能に係合する形態とされた第 二のねじを有し、 前記損傷した椎骨を除去することにより形成されるスペースの外側にて前記隣 接する完全な椎骨を跨ぎ且つ該椎骨に固定状態に係合し得る寸法とされた細長い 長手方向部材と、 前記椎骨代替用インプラントを前記長手方向部材に接続する手段とを備える、 組立体。 24.隣接する完全な椎骨を固定する請求項23に記載の組立体にして、 前記代替物体が多数のねじ付き開口部を画成し、 前記接続手段が、 前記長手方向部材をクランプ止めするクランプと、 該クランプに取り付けられたねじであって、前記多数のねじ付き開口部の1 つに係合するねじと、前記クランプを前記長手方向部材に係合させたとき、前記 ねじが前記代替物体に係合するのに十分な長さを有する前記ねじとを備える、組 立体。 25.隣接する完全な椎骨を固定する請求項24に記載の組立体にして、 前記クランプが、円形の着座部を有する穴を画成するプレートを備え、 前記ねじが、前記円形の着座部に係合する形態とされた丸形の頭部を備える、 組立体。 26.隣接する完全な椎骨を固定する請求項22に記載の組立体にして、 前記端板の各々が、前記端面を画成するフランジであって、前記円筒状部分か ら外方に伸長する前記フランジを備え、 前記接続手段が、前記フランジと一体で且つ前記円筒状部分から突き出すアー ムを備え、該アームが、前記長手方向部材に係合し得るように、前記隣接する完 全な椎骨を超えて伸長する形態とされた自由端を有する、組立体。 27.隣接する完全な椎骨を固定する請求項26に記載の組立体にして、 前記アームが、前記長手方向部材を受け入れるべく前記自由端に形成された第 一の穴と、該第一の穴を横断するように前記自由端に形成された止めねじ穴とを 画成し、 前記接続手段が、前記止めねじ穴内にねじ込まれる止めねじを有し、 該止めねじが、前記第一の穴を貫通して伸長する長手方向部材に係合する先端 を有する、組立体。 28.隣接する完全な椎骨の間にて除去した椎骨により形成されるスペース内に 介在される椎骨代替用インプラントにして、 両端を有し且つ前記完全な椎骨間のスペースの一部を跨ぐ寸法とされた長さを 有する代替物体と、 前記インプラントが前記スペース内に介在されたとき、前記完全な椎骨のそれ ぞれの1つに接触する端面を有する一対の端板であって、その各々が、前記端面 から一体に伸長する係合部分を有する前記一対の端板と、 前記代替物体の前記長さに沿った可変位置にて前記端板を前記代替物体に係合 させるべく前記代替物体の前記両端と前記端板の各々の前記係合部分との間に設 けられた手段とを備える、椎骨代替用インプラント。 29.請求項28に記載の椎骨代替用インプラントにして、前記係合手段が、前 記代替物体の前記両端上に及び前記端板係合部分の各々に形成されたかみ合いね じを含む、椎骨代替用インプラント。 30.請求項28に記載の椎骨代替用インプラントにして、前記代替物体を前記 端板の各々に固定して、前記係合手段が非係合状態となるのを防止する手段を更 に備える、椎骨代替用インプラント。 31.2つの完全な椎骨の間にて除去した椎骨により形成されるスペース内に介 在される椎骨代替用インプラントにして、 中空の内部を画成する肉厚の薄い円筒体を備え、該円筒体の壁が、該円筒体の 外表面積の25%に少なくとも等しい合計面積を有する複数の穴を画成し、 該円筒体が前記両端の各々に形成された連続的なねじを有する両端を備え、 一対の端板を備え、該端板の各々が、インプラントが前記スペース内に介在さ れたとき、前記完全な椎骨のそれぞれの1つと接触する端面を画成するフランジ により形成され、 該端板の各々が、前記フランジから一体に突き出す円筒状部分を更に備え、 該円筒状部分が、前記肉厚の薄い円筒体の両端における前記ねじと係合する連 続的なねじを画成し、 前記端板の各々が、前記円筒体が前記端板と螺着可能に係合したとき、前記肉 厚の薄い円筒体の前記中空の内部と連通する貫通穴を画成する、椎骨代替用イン プラント。 32.請求項31に記載の椎骨代替用インプラントにして、 前記端板の各々の前記円筒状部分が前記端面から突き出す長さを有し、 前記円筒状部分が、該円筒状部分の前記長さの一部に沿って形成された圧着切 欠きを画成し、 該円筒状部分が前記圧着切欠きにて変形し、前記切欠きを閉じ、これにより、 前記円筒体が前記端板の円筒状部分と螺着可能に係合したとき、前記円筒体の周 りにおける前記円筒状部分の外周が小さくなるようにした、椎骨代替用インプラ ント。 33.請求項2に記載の椎骨代替用インプラントにして、前記複数の穴の一部が 前記代替物体の前記第一のねじを貫通して伸長する、椎骨代替用インプラント。 34.請求項7に記載の椎骨代替用インプラントにして、前記代替物体が中空の 内部を画成する円筒状壁を有し、 該円筒状壁が複数の貫通穴を画成し、 該穴が前記代替物体の前記中空の内部と連通し、前記代替物体内への組織の内 部成長を促進する、椎骨代替用インプラント。 35.請求項34に記載の椎骨代替用インプラントにして、前記複数の穴の一部 が前記代替物体の前記雄ねじを貫通して伸長する、椎骨代替用インプラント。
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US35356694A | 1994-12-09 | 1994-12-09 | |
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PCT/US1995/015654 WO1996017564A1 (en) | 1994-12-09 | 1995-12-01 | Adjustable vertebral body replacement |
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JP51767296A Expired - Fee Related JP3732228B2 (ja) | 1994-12-09 | 1995-12-01 | 可調節型の椎骨体代替物 |
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US (1) | US5702453A (ja) |
EP (3) | EP1512385B1 (ja) |
JP (1) | JP3732228B2 (ja) |
AT (3) | ATE289786T1 (ja) |
AU (2) | AU4372596A (ja) |
CA (1) | CA2207336A1 (ja) |
DE (3) | DE69534042T2 (ja) |
ES (3) | ES2259169T3 (ja) |
PT (1) | PT1077659E (ja) |
WO (2) | WO1996017564A1 (ja) |
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- 1995-12-01 AU AU43725/96A patent/AU4372596A/en not_active Abandoned
- 1995-12-01 ES ES04025962T patent/ES2259169T3/es not_active Expired - Lifetime
- 1995-12-01 DE DE69534042T patent/DE69534042T2/de not_active Expired - Fee Related
- 1995-12-01 EP EP95942527A patent/EP0797418B1/en not_active Expired - Lifetime
- 1995-12-01 ES ES95942527T patent/ES2238684T3/es not_active Expired - Lifetime
- 1995-12-01 AT AT95942527T patent/ATE289786T1/de not_active IP Right Cessation
- 1995-12-01 JP JP51767296A patent/JP3732228B2/ja not_active Expired - Fee Related
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- 1995-12-01 DE DE69534978T patent/DE69534978T2/de not_active Expired - Fee Related
- 1995-12-08 ZA ZA9510445A patent/ZA9510445B/xx unknown
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1996
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1999
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- 1999-04-29 AT AT99921520T patent/ATE263525T1/de not_active IP Right Cessation
- 1999-04-29 ES ES99921520T patent/ES2217752T3/es not_active Expired - Lifetime
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JP2000508187A (ja) * | 1996-04-03 | 2000-07-04 | シンアンティクス ソシエテ ア レスポンサビリテ リミテ | 体幹間融合固定装置 |
JP2006520665A (ja) * | 2003-03-20 | 2006-09-14 | エスディージーアイ・ホールディングス・インコーポレーテッド | 椎骨置換装置 |
JP2007517628A (ja) * | 2004-01-15 | 2007-07-05 | ウォーソー・オーソペディック・インコーポレーテッド | ユニバーサル締り嵌めクリート |
JP2008289628A (ja) * | 2007-05-24 | 2008-12-04 | Ehime Univ | 骨補填ブロックおよび骨補填ブロックを含む骨接合用キット |
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WO1999056675A1 (en) | 1999-11-11 |
ES2217752T3 (es) | 2004-11-01 |
DE69534978T2 (de) | 2007-01-04 |
ZA9510445B (en) | 1996-06-19 |
EP1512385B1 (en) | 2006-05-03 |
PT1077659E (pt) | 2004-08-31 |
CA2207336A1 (en) | 1996-06-13 |
ES2238684T3 (es) | 2005-09-01 |
WO1996017564A1 (en) | 1996-06-13 |
DE69916261D1 (de) | 2004-05-13 |
ATE263525T1 (de) | 2004-04-15 |
EP1512385A1 (en) | 2005-03-09 |
EP0797418B1 (en) | 2005-03-02 |
DE69916261T2 (de) | 2005-04-14 |
DE69534042T2 (de) | 2006-04-13 |
ATE324846T1 (de) | 2006-06-15 |
ATE289786T1 (de) | 2005-03-15 |
US5702453A (en) | 1997-12-30 |
EP0797418A4 (en) | 2003-01-22 |
JP3732228B2 (ja) | 2006-01-05 |
ES2259169T3 (es) | 2006-09-16 |
EP0797418A1 (en) | 1997-10-01 |
AU3871199A (en) | 1999-11-23 |
EP1077659B1 (en) | 2004-04-07 |
DE69534978D1 (de) | 2006-06-08 |
EP1077659A1 (en) | 2001-02-28 |
AU4372596A (en) | 1996-06-26 |
DE69534042D1 (de) | 2005-04-07 |
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