JPH10504705A - 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 - Google Patents
色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列Info
- Publication number
- JPH10504705A JPH10504705A JP8501287A JP50128796A JPH10504705A JP H10504705 A JPH10504705 A JP H10504705A JP 8501287 A JP8501287 A JP 8501287A JP 50128796 A JP50128796 A JP 50128796A JP H10504705 A JPH10504705 A JP H10504705A
- Authority
- JP
- Japan
- Prior art keywords
- pedf
- cells
- antibody
- protein
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. ニューロンを含む細胞集団を有効量の色素上皮誘導因子で処理し;お よび 該集団のニューロン細胞生存を促進することからなるニューロン細胞 生存の促進法。 2. グリア細胞を含む細胞集団を有効量の色素上皮誘導因子で処理し;お よび 該集団のグリア細胞増殖を阻害することからなるグリア細胞増殖阻害 法。 3. ニューロン細胞が組織細胞培養にある請求項第1項に記載の方法。 4. 以下の工程をさらに含む請求項第1項に記載の方法: 細胞培養を設定し;および 該細胞培養を有効量のPEDFで処理する。 5. 処理される細胞が患者内へ移植される組織の構成要素を含む請求項第 1項に記載の方法。 6. 細胞が胎児脳細胞である請求項第6項に記載の方法。 7. グリア細胞が腫瘍増殖の一部である請求項第2項に記載の方法。 8. 阻害されるグリア細胞増殖がグリオシスである請求項第2項に記載の 方法。 9. 精製された色素上皮誘導因子またはその抗原性断片に対して作成され た精製抗体または該抗体の抗原ー結合断片。 10. 該抗体がポリクローナルである請求項第9項に記載の単離抗体または 抗体断片。 11. 該抗体がモノクローナルである請求項第9項に記載の抗体または抗体 断片。 12. 該抗体が検出可能な標識で標識されている請求項第9項に記載の抗体 または抗体断片。 13. 細胞または細胞集団を有効量の請求項第9項に記載の抗体または該抗 体の抗原結合断片で処理し;および 色素上皮誘導因子生物学的活性を阻害することからなる色素上皮誘導 因子の阻害法。 14. 以下の工程を含んでなる、体液、細胞または組織試料中の色素上皮誘 導因子レベルの決定法: A.該試料と請求項第9項に記載の精製抗体または抗原結合断片を該 抗体または抗原結合断片と該試料中に存在する色素上皮誘導因子間で免疫複合体 が形成される条件下で接触させ; B.免疫複合体から過剰の抗体または抗原結合断片を分離し;及び C.免疫複合体のレベルを決定して色素上皮誘導因子レベルを決定す る。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/257,963 US5840686A (en) | 1992-09-24 | 1994-06-07 | Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use |
US08/367,841 | 1994-12-30 | ||
US08/257,963 | 1994-12-30 | ||
US08/367,841 US6319687B1 (en) | 1992-09-24 | 1994-12-30 | Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene |
PCT/US1995/007201 WO1995033480A1 (en) | 1994-06-07 | 1995-06-06 | Pigment epithelium-derived factor: characterization, genomic organization and sequence of the pedf gene |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006033129A Division JP2006149405A (ja) | 1994-06-07 | 2006-02-09 | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10504705A true JPH10504705A (ja) | 1998-05-12 |
Family
ID=26946312
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8501287A Withdrawn JPH10504705A (ja) | 1994-06-07 | 1995-06-06 | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 |
JP2006033129A Withdrawn JP2006149405A (ja) | 1994-06-07 | 2006-02-09 | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 |
JP2009011452A Expired - Lifetime JP5108797B2 (ja) | 1994-06-07 | 2009-01-21 | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006033129A Withdrawn JP2006149405A (ja) | 1994-06-07 | 2006-02-09 | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 |
JP2009011452A Expired - Lifetime JP5108797B2 (ja) | 1994-06-07 | 2009-01-21 | 色素上皮誘導因子:pedf遺伝子の特性評価、ゲノム構成および配列 |
Country Status (9)
Country | Link |
---|---|
US (3) | US6319687B1 (ja) |
EP (2) | EP1864678B1 (ja) |
JP (3) | JPH10504705A (ja) |
AT (2) | ATE451118T1 (ja) |
AU (1) | AU710141B2 (ja) |
CA (2) | CA2190365C (ja) |
DE (2) | DE69536028D1 (ja) |
ES (1) | ES2288300T3 (ja) |
WO (1) | WO1995033480A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006046584A1 (ja) * | 2004-10-26 | 2006-05-04 | Santen Pharmaceutical Co., Ltd. | 視細胞障害治療剤 |
JP2009519006A (ja) * | 2005-11-14 | 2009-05-14 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 改善された色素上皮由来因子変異体及びその使用 |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856097A (en) | 1992-03-04 | 1999-01-05 | The Regents Of The University Of California | Comparative genomic hybridization (CGH) |
US6319687B1 (en) * | 1992-09-24 | 2001-11-20 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene |
US6451763B1 (en) * | 1992-06-04 | 2002-09-17 | The United States Of America As Represented By The Department Of Health And Human Services | Retinal pigmented epithelium derived neurotrophic factor and methods of use |
US7049424B2 (en) | 1996-07-15 | 2006-05-23 | The Regents Of The University Of California | Genes from the 20Q13 amplicon and their uses |
US7455964B1 (en) | 1996-07-15 | 2008-11-25 | The Hospital For Sick Children | Genes from the 20q13 amplicon and their uses |
US5801021A (en) | 1995-10-20 | 1998-09-01 | The Regents Of The University Of California | Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer |
WO1998024812A2 (en) * | 1996-12-03 | 1998-06-11 | Neurocrine Biosciences, Inc. | A6la5a12 polypeptides and polynucleotides and methods of use therefor |
US6350467B1 (en) | 1996-12-31 | 2002-02-26 | Antioxidant Pharmaceuticals Corp. | Pharmaceutical preparations of glutathione and methods of administration thereof |
US6797691B1 (en) | 1997-07-23 | 2004-09-28 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
US7105496B2 (en) | 1998-07-23 | 2006-09-12 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
US6288024B1 (en) | 1997-07-23 | 2001-09-11 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
WO1999011799A2 (en) * | 1997-09-02 | 1999-03-11 | Medical College Of Georgia Research Institute, Inc. | Human aminopeptidase p gene |
CA2368376A1 (en) * | 1999-03-26 | 2000-10-05 | Human Genome Sciences, Inc. | 50 human secreted proteins |
CA2382735A1 (en) * | 1999-06-11 | 2000-12-21 | Human Genome Sciences, Inc. | 49 human secreted proteins |
US6821775B1 (en) | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
JP2003522160A (ja) * | 2000-02-11 | 2003-07-22 | ジェンベク、インコーポレイティッド | 眼関連疾患の治療のための遺伝子治療 |
EP1265627B1 (en) * | 2000-02-23 | 2008-11-05 | Northwestern University | Pharmaceutical compositions for inhibiting angiogenesis by pedf fragments |
EP1259818A2 (en) * | 2000-02-24 | 2002-11-27 | Oxford GlycoSciences (UK) Limited | Diagnosis and treatment of schizophrenia |
IL147444A0 (en) * | 2002-01-03 | 2002-08-14 | Yeda Res & Dev | Process for the production of pigment epithelium derived factor (pedf) from human blood and uses thereof |
US20030158112A1 (en) | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
JP2006506970A (ja) * | 2002-07-12 | 2006-03-02 | ユニバーシティ オブ ワシントン | 神経細胞の延長されたインビトロ培養のための方法および系 |
US20040161423A1 (en) * | 2002-07-18 | 2004-08-19 | Sanjeev Kumar (Mendiratta) | Polymer modified anti-angiogenic serpins |
US20050222031A1 (en) * | 2004-03-19 | 2005-10-06 | Yamagishi Sho-Ichi | Method for preventing or treating malignant melanoma |
CA2588093A1 (en) * | 2004-11-16 | 2006-05-26 | Rony Seger | Variants of pigment epithelium derived factor and uses thereof |
US7358085B2 (en) * | 2005-02-28 | 2008-04-15 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
GB0516058D0 (en) * | 2005-08-04 | 2005-09-14 | Oxford Genome Sciences Uk Ltd | New protein isoforms and uses thereof |
US20090069241A1 (en) * | 2006-02-15 | 2009-03-12 | Yale University | Compositions and Methods for Use of Pigment Epithelial Derived Factor (PEDF) Peptide Fragments |
ITTV20080039A1 (it) * | 2008-03-06 | 2009-09-07 | Alpinestars Research Srl | Collare di protezione in particolare per guidatori di motoveicoli |
JP2013507373A (ja) * | 2009-10-08 | 2013-03-04 | ニューロテック ユーエスエー, インコーポレイテッド | 被包された細胞ベースの送達系におけるpedfの使用 |
WO2014040302A1 (en) * | 2012-09-17 | 2014-03-20 | Yeou-Ping Tsao | Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation |
WO2015038891A2 (en) | 2013-09-13 | 2015-03-19 | The Penn State Research Foundation | Functional peptide analogs of pedf |
JP6522063B2 (ja) * | 2017-08-10 | 2019-05-29 | マクカイ メモリアル ホスピタル | 脱毛症及び/又は毛髪色素脱失を治療するためのpedf由来のポリペプチドの使用 |
KR101998155B1 (ko) * | 2017-09-22 | 2019-07-10 | (주)케어젠 | 혈관신생 억제용 펩타이드 및 이의 용도 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1700691A (en) | 1927-03-08 | 1929-01-29 | Lilly Co Eli | Optic-nerve and retina extract and process of making it |
FR2461002A1 (fr) | 1979-07-13 | 1981-01-30 | Inst Nat Sante Rech Med | Procede pour stimuler la croissance des cellules d'epiderme humain et produits faisant application dudit procede |
US4477435A (en) | 1981-05-19 | 1984-10-16 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for regenerating corneal epithelium |
US4534967A (en) | 1982-08-03 | 1985-08-13 | Boston Biomedical Research Institute | Cell proliferation inhibitor and method of preparation |
US4770877A (en) | 1982-08-03 | 1988-09-13 | Boston Biomedical Research Institute | Isolation of a high molecular weight aortic endothelial cell growth inhibitor |
US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
AU590872B2 (en) | 1985-02-26 | 1989-11-23 | Johns Hopkins University, The | Neovascularization inhibitors and methods for their production and use |
US5244902A (en) * | 1989-08-21 | 1993-09-14 | Beth Israel Hospital Association | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses |
US6451763B1 (en) * | 1992-06-04 | 2002-09-17 | The United States Of America As Represented By The Department Of Health And Human Services | Retinal pigmented epithelium derived neurotrophic factor and methods of use |
WO1993024529A1 (en) * | 1992-06-04 | 1993-12-09 | University Of Southern California | Retinal pigmented epithelium derived neurotrophic factor |
US5840686A (en) * | 1992-09-24 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use |
US6319687B1 (en) * | 1992-09-24 | 2001-11-20 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene |
FI104514B (fi) * | 1997-02-18 | 2000-02-15 | Safematic Oy | Sovitelma kiertovoitelujärjestelmän yhteydessä |
US6319781B1 (en) * | 2001-02-28 | 2001-11-20 | Macronix International Co., Ltd. | Method of fabricating self-aligned multilevel mask ROM |
-
1994
- 1994-12-30 US US08/367,841 patent/US6319687B1/en not_active Expired - Lifetime
-
1995
- 1995-06-06 JP JP8501287A patent/JPH10504705A/ja not_active Withdrawn
- 1995-06-06 ES ES95922988T patent/ES2288300T3/es not_active Expired - Lifetime
- 1995-06-06 EP EP07007638A patent/EP1864678B1/en not_active Expired - Lifetime
- 1995-06-06 AT AT07007638T patent/ATE451118T1/de not_active IP Right Cessation
- 1995-06-06 DE DE69536028T patent/DE69536028D1/de not_active Expired - Lifetime
- 1995-06-06 WO PCT/US1995/007201 patent/WO1995033480A1/en active IP Right Grant
- 1995-06-06 AT AT95922988T patent/ATE359810T1/de not_active IP Right Cessation
- 1995-06-06 CA CA2190365A patent/CA2190365C/en not_active Expired - Fee Related
- 1995-06-06 CA CA2704083A patent/CA2704083C/en not_active Expired - Fee Related
- 1995-06-06 DE DE69535467T patent/DE69535467T2/de not_active Expired - Lifetime
- 1995-06-06 EP EP95922988A patent/EP0765169B1/en not_active Expired - Lifetime
- 1995-06-06 AU AU27681/95A patent/AU710141B2/en not_active Ceased
-
2000
- 2000-08-01 US US09/630,629 patent/US7179621B1/en not_active Expired - Fee Related
-
2005
- 2005-08-10 US US11/201,443 patent/US20060008900A1/en not_active Abandoned
-
2006
- 2006-02-09 JP JP2006033129A patent/JP2006149405A/ja not_active Withdrawn
-
2009
- 2009-01-21 JP JP2009011452A patent/JP5108797B2/ja not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006046584A1 (ja) * | 2004-10-26 | 2006-05-04 | Santen Pharmaceutical Co., Ltd. | 視細胞障害治療剤 |
JP2009519006A (ja) * | 2005-11-14 | 2009-05-14 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 改善された色素上皮由来因子変異体及びその使用 |
Also Published As
Publication number | Publication date |
---|---|
ATE359810T1 (de) | 2007-05-15 |
CA2190365A1 (en) | 1995-12-14 |
AU710141B2 (en) | 1999-09-16 |
CA2704083C (en) | 2013-07-30 |
US6319687B1 (en) | 2001-11-20 |
ES2288300T3 (es) | 2008-01-01 |
JP2009153517A (ja) | 2009-07-16 |
ATE451118T1 (de) | 2009-12-15 |
CA2704083A1 (en) | 1995-12-14 |
US20060008900A1 (en) | 2006-01-12 |
EP1864678A1 (en) | 2007-12-12 |
EP1864678B1 (en) | 2009-12-09 |
CA2190365C (en) | 2010-08-03 |
JP5108797B2 (ja) | 2012-12-26 |
WO1995033480A1 (en) | 1995-12-14 |
JP2006149405A (ja) | 2006-06-15 |
EP0765169B1 (en) | 2007-04-18 |
DE69535467D1 (de) | 2007-05-31 |
DE69535467T2 (de) | 2008-01-03 |
DE69536028D1 (de) | 2010-01-21 |
US7179621B1 (en) | 2007-02-20 |
EP0765169A1 (en) | 1997-04-02 |
AU2768195A (en) | 1996-01-04 |
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